<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06264

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMKNLRFYPFIIMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIITFTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNARGHNSTQASGNFASNATTNSMPYQNGTVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQPQPQQLNIVGSSQQQQQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGQVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSACPTPDILRPVHICRRSWYSFGIAVFQKLWKVEFHSYFYTHRNDQSDKIVGNSDGCMASTIAHIWRNGAAFLARGDQTGRSGNDIFSLLSSFVSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFTQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTH
Length2272
PositionTail
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.104
Instability index46.16
Isoelectric point7.12
Molecular weight261601.24
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06264
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.86|      21|      41|     755|     793|       1
---------------------------------------------------------------------------
  771-  791 (46.42/34.56)	TQQQQQQQQQQQQQQQQQQQ.....Q
  814-  839 (39.44/11.25)	SQQQQQQQQQQQQQQQQQQQshfllK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.35|      66|      80|    1393|    1472|       2
---------------------------------------------------------------------------
 1402- 1472 (107.49/94.90)	SLQQKLRYI.....SF.AQGEQSGTpfSACPTPDILRP.VHIC..RRSWYSFgIAVFQKLwkVEFHSYFYTHRNDQSDKI
 1479- 1553 (104.86/58.14)	CMASTIAHIwrngaAFlARGDQTGR..SGNDIFSLLSSfVSIFwhRGSGYGY.CWCFQIL..LDDRPYWWVHTAGVSGQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.81|      33|      80|     952|     987|       3
---------------------------------------------------------------------------
  952-  987 (51.97/43.04)	YEGNDAFYALLIVMLLVQRseeLRSAVADCVAMLPS
 1033- 1065 (58.84/40.40)	YFGTRCLQMLPVVDLLLQK...LVESPAACLKFLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      80|     284|     298|       4
---------------------------------------------------------------------------
  284-  298 (28.85/20.51)	RLLTHVFMHYTYRDA
  366-  380 (28.86/20.53)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.80|      29|      63|    1179|    1207|       5
---------------------------------------------------------------------------
 1179- 1207 (49.50/30.00)	NNF..QTHALYCI.CIELM..SLSVSVVDVGNAL
 1215- 1243 (18.14/ 6.23)	HSLvdKNTVMYWVnAIGLIfsALPISYME.....
 1245- 1269 (37.17/20.65)	..F..YQTILTTL.CSDHM..N.SMN.TDVSNKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.63|      53|      64|    1704|    1758|       7
---------------------------------------------------------------------------
 1704- 1758 (82.64/59.70)	PLASFFRDVGVLISIAMLLANKSMHTNN....NNNNITSKPFSSKftQALLGVGL.NQLV
 1767- 1824 (78.98/50.46)	PIALFYAVLLPIVSICCFVVNMVLDLDNfrveKGGNVQAVRISQQ..KRFQSVDLvDQVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.10|      35|      85|     129|     165|       8
---------------------------------------------------------------------------
  129-  165 (62.05/40.63)	C..GW..NDTFAFFMEniSLLDYKGVRDTLKRLLDIPIPVH
  210-  248 (58.05/32.52)	CfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.09|      22|     659|    1354|    1382|      10
---------------------------------------------------------------------------
 1354- 1382 (36.85/43.71)	QMLYNVdcevsswKYEDLICDFFYHVKYM
 2000- 2021 (43.25/29.63)	HMLYKK.......KYTPLYTPFFMRKEVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.19|      54|     872|     424|     480|      15
---------------------------------------------------------------------------
  424-  480 (88.45/66.97)	SGSDSSCVLMLAPTCIWI.HILKKSPSMEV..ELPPTVntQRkFLQEALKNKTQFNTDNY
 1297- 1353 (86.74/55.19)	SASGYLQLLPQALRSTWIpHVRSEGQFLYVchLVAPFL..QR.FYQERTKFTMDITTDLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06264 with Med23 domain of Kingdom Metazoa
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