<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06263

Description "Serine--tRNA ligase, cytoplasmic"
SequenceMKNLRFYPFIIMSLSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKIITFTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDFFVRDVTQRQILSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSGKSAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQPQPQQLNIVGSSQQQQQQQQQQQQQQQQQQQSHFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGQVTDRGPWVPDLNYYAALVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWKYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSACPTPDILRPVHICRRSWYSFGIAVFQKLWKVEFHSYFYTHRNDQSDKIVGNSDGCMASTIAHIWRNGAAFLARGDQTGRSGNDIFSLLSSFVSIFWHRGSGYGYCWCFQILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLSGLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAMLLANKSMHTNNNNNNITSKPFSSKFTQALLGVGLNQLVALIPIGRLPIALFYAVLLPIVSICCFVVNMVLDLDNFRVEKGGNVQAVRISQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVHGDSTLPDSLTDKLQKVTVDQIRALSVSQIKQLRLLIDHEMEKSDKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLYKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEDIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYIGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMILNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYEFVHMLNGTMCATTRTICAILENFQEENGIVVPEALRPYMPDDYKDFIPFVKAAPKVDQQAAKRGNKSATEKSTH
Length1928
PositionTail
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.118
Instability index47.18
Isoelectric point6.86
Molecular weight222122.93
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06263
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.86|      21|      41|     411|     449|       1
---------------------------------------------------------------------------
  427-  447 (46.42/37.80)	TQQQQQQQQQQQQQQQQQQQ.....Q
  470-  495 (39.44/12.33)	SQQQQQQQQQQQQQQQQQQQshfllK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.83|      18|      49|    1249|    1268|       2
---------------------------------------------------------------------------
 1258- 1302 (16.22/ 9.92)	CWLLYVVFLIAvsisrtyisahfpdqvilgivvgiciaLVTRSLV
 1308- 1325 (30.61/14.00)	RWSNLIAFMIA...........................LLLIALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     320.95|      77|      80|    1049|    1128|       3
---------------------------------------------------------------------------
  970- 1047 (96.25/55.32)	IPHVRS..EGQFLYVchlvaPF.LQRfYQERTKFTMDITTDLYQM.LYNvdC..EVSSWKYEDLICDFFYHVKYM.YVGDSVRQE....
 1052- 1128 (137.04/91.32)	IPMLRTSLQQKLRYI.....SF.AQG.EQSGTPFSACPTPDILRP.VHI..C..RRSWYSFGIAVFQKLWKVEFHSYFYTHRNDQSDKI
 1135- 1209 (87.66/52.11)	......CMASTIAHIwrngaAFlARG.DQTGR..SGNDIFSLLSSfVSI..FwhRGSGYGY.CWCFQIL..LDDRPYWWVHTAGVSGQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.53|      43|      57|     637|     681|       4
---------------------------------------------------------------------------
  637-  681 (74.52/45.29)	CVAMLPSDYWHCQDWNDKYQAYqLKHAERTWSqVHTELSRASLTP
  694-  736 (77.02/39.37)	CLQMLPVVDLLLQKLVESPAAC.LKFLDSTLS.ILGPLYRFHPYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.18|      21|      57|     151|     171|       5
---------------------------------------------------------------------------
  151-  171 (38.73/24.99)	LNPQM.RLLTHVFMHYTYRDAI
  210-  231 (27.80/15.72)	LNPQAwRIISTQIIYLTLQQSI
  232-  252 (25.65/13.90)	CFTRLvKILHTKLTHYPYRYA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.85|      27|      31|      60|      88|       6
---------------------------------------------------------------------------
   60-   88 (40.27/33.66)	ANELVEIFtsVPQNLQESAFSI.VISHRVL
   92-  119 (42.58/28.64)	ANKIVDFF..VRDVTQRQILSIkCICEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.72|      16|      31|     287|     303|       8
---------------------------------------------------------------------------
  287-  303 (25.66/19.45)	CRMLtYADLEILGLKQF
  317-  332 (34.06/21.41)	CEMM.YICCEILNYRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.13|      14|      33|     898|     913|       9
---------------------------------------------------------------------------
  898-  913 (23.43/18.88)	MEPFYQTILTTLCsdH
  934-  947 (28.70/16.27)	MEDCYPARILALC..H
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06263 with Med23 domain of Kingdom Metazoa
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