<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06260

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLFWMTSFNASLIKCTITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPAFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMATFHVAGEFEAKLTLLGQLPRTPWTLLKLRILVSDPRVTDGSDVLSSLQLSYLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYISSEKLVISYWKERNQGGIASFKIIFWINQDEPFAPLQVSHIPKSDLKLPTMDTESGQLALDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSVTFLPGSNSTEILDLSMNLFTGKFVCRLPAFDEDISLIAELTEKLDDNHWNCLEDLLHQIRVRIFMNRVDHAMRFFTLKVCETLPAFLKTTCEQWPIDRRLIIKFHRFENYFIVLTFNDHPDDSTKVNLDFWLVCNETVSNAIRSADDDDRSKKNVNLLHFDLRKFVSESKVFNQLCLLSLKIQKKQCAIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTCDHNFEKILGLPKGLAISLSYDRHRLVWSMELNTVGSPLGDSFSFGKAVHRKITILTCTVGNESARKCLDDVSSGVRCFSALYEPVKALARAYKGCLHRLTPLSMLSSYKLTLVYGQKLRYVCHLQWKPSERMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNSVRDISALSHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSIFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVNDSFMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRISTQNRLAGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQVKRKPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNATAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHVYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGSAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNNTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1315
PositionTail
OrganismTrichinella zimbabwensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.034
Instability index40.91
Isoelectric point6.43
Molecular weight149721.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06260
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.32|      52|     360|     123|     174|       1
---------------------------------------------------------------------------
  123-  174 (88.67/61.55)	DQQASMFVDTADRL..YQMNC..DVLQNARLPAF..QIPTAVDVLTLGTYPRLPSVIK
  465-  522 (79.65/54.45)	DEDISLIAELTEKLddNHWNCleDLLHQIRVRIFmnRVDHAMRFFTLKVCETLPAFLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.64|      45|     459|     342|     460|       4
---------------------------------------------------------------------------
  408-  458 (67.24/147.09)	LQQLCDFLRTIKGLTCTFISdmpalSVTFLPGSNS..TEILDLSMnLFTGKFV
 1189- 1235 (76.40/21.07)	IPEMCFLIPSPQLVPTTYLS.....RATLMPGGSAivANVVQKKM.LFWIKFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.93|      39|     459|      79|     120|       6
---------------------------------------------------------------------------
   79-  120 (55.99/57.22)	LDRKIsIAQFaHSARQLFVRLyAILKWARCGAKVDLCTGIVC
  530-  568 (71.94/54.61)	IDRRL.IIKF.HRFENYFIVL.TFNDHPDDSTKVNLDFWLVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.75|      19|     358|      37|      55|       8
---------------------------------------------------------------------------
   37-   55 (35.99/26.86)	LPSIPANQGPPFMAFGVLL
  360-  372 (16.61/ 7.45)	......NQDEPFAPLQVSH
  380-  396 (27.15/18.01)	LPTMDTESGQ..LALDNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.50|      50|     845|     211|     342|      10
---------------------------------------------------------------------------
  289-  342 (75.52/164.78)	EPIVELYRVIHCFCLSAQLDIlcCQAYR..LIGDFMSeNLSVEEYISSEKlVISYW
 1137- 1188 (81.98/25.31)	EQISSTYNATAMYAFVRMLTV..CQTIRrdLLSSFLS.IMNIQQHVYVES.STAYW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06260 with Med14 domain of Kingdom Metazoa
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