<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06241

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLLLLLVSSVIFFINLQLFFLYCLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQIQQQIQQHQQQQQQLQAQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKVKDRNINQPLLDAISAITKPERQKINLYEYFNFPLYQCSLKNTCPDCLKGSCENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length755
PositionTail
OrganismTrichinella britovi (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.722
Instability index76.85
Isoelectric point7.67
Molecular weight85879.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06241
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     285.36|      57|      58|     249|     305|       1
---------------------------------------------------------------------------
   32-   75 (43.83/ 7.16)	.......................................RSQRQRE.......................KVIQHLDN...V....IRSCT...VPLNI..PGDARQVENaiFLK.....AN..NQ
   98-  184 (77.10/17.72)	QPQ.....RHQApvNQVpygnmqpgtqfrradmrpmQQPMQQQQQQ.......................QQQQQ.QQ...Q....VPGQIysgMRAPPnaEMQPRLLRP..MHQpsvtmHHMHQQ
  185-  276 (63.37/13.36)	QAQmgqmgMTQS..AGI...................AAAAQQQPQNvvmlltsgnpprqaasapsavqlRQPNDIQQflqQlppaIRQQI...LQLPP..EEQAEQLKK..FFE.....SRRWQQ
  277-  303 (43.92/ 7.19)	QQQ.....LHQQ..QQI...................QQQQQQQQQQ.......................QQQQQIQ.................................................
  331-  357 (57.15/11.39)	QNQ.....MHTQ..AVI...................QQQQQQQQQQ.......................QQQQQ.................................................QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.77|      11|      19|     404|     414|       2
---------------------------------------------------------------------------
  404-  414 (22.79/10.77)	TPVMIP.QTPAP
  451-  460 (19.40/ 7.84)	AHMMGP..SPAY
  465-  476 (17.59/ 6.28)	SPVCHPaATPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      17|      51|     307|     323|       3
---------------------------------------------------------------------------
  307-  323 (31.31/10.80)	QQHQQQQQQLQAQQQIQ
  359-  375 (33.00/11.86)	QQHQQQFASVRQQQQMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.49|      10|      16|     645|     655|       5
---------------------------------------------------------------------------
  645-  655 (13.60/13.59)	QREIGSlESKF
  663-  672 (19.89/14.01)	QRPLRS.SCKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06241 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LQAQQQIQHQMHHVAQNQMHTQAVIQQQQQQ
2) MSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQ
3) QQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
316
96
350
346
244
499










Molecular Recognition Features






MoRF SequenceStartStop




NANANA