<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06220

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEECEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANKIVDFFVRNVIQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQPQQPQQQQQQQQQPQPQQSNVVVGSSQQPQQQQQSRFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDNMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAALDMAIVGAFSEISNCILKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPIGRLPTALFYAVLLPALIVLLLTMVLDLDNFRVEKGGNVQAVRVSQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVDGNSTLPDSLTDKLQKLTVDQIRALSVGQIKQLRLLIDHEMEKSYKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLFKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEEIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYVGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMISNAEVFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYGQTKKMMAKAEFVHMLNGTMCATTRTICAILENFQEENGIAVPEALRQYMPDDYKDFIPFVKPAPKVEQAAKRGGNKSAAAEKSTQ
Length2227
PositionTail
OrganismTrichinella britovi (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.051
Instability index44.40
Isoelectric point6.92
Molecular weight255654.38
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06220
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.57|      16|      17|     760|     775|       1
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  760-  775 (34.63/18.20)	QQQQQQQQQQQQQQQQ
  778-  793 (34.57/18.16)	QQQPQQPQQQQQQQQQ
  807-  822 (29.37/14.42)	QQPQQQQQSRFLLKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.41|      47|      80|     919|     968|       2
---------------------------------------------------------------------------
  919-  968 (77.00/54.52)	VPLERFMLT...MLLRDYEGNDAFYALLIVMLLVQRseeLRSAVADCVAMLPS
  997- 1046 (78.41/48.34)	VELSRASLTpndCPLPVYFGTRCLQMLPVVDLLLQK...LVESPAACLKFLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.26|      52|      81|    1564|    1627|       3
---------------------------------------------------------------------------
 1564- 1617 (83.16/58.52)	SRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNliAFMIALLLIALS
 1649- 1684 (44.64/33.00)	STTPLASFFRD...VGVLISVAILLANKSMFTNNNKIAS...............
 1686- 1726 (60.46/36.92)	...FFSTKFA.QALLGVGLNQLVAFIP...IG....RLPT..ALFYAVLLPALI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      81|     273|     287|       4
---------------------------------------------------------------------------
  273-  287 (28.85/19.18)	RLLTHVFMHYTYRDA
  355-  369 (28.86/19.19)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.13|      41|      85|     112|     154|       5
---------------------------------------------------------------------------
  112-  154 (70.99/43.23)	ELNINSC..GW..NDTFAFFMEniSLLDYKGVRDTLKRLLDIPIPVH
  193-  237 (68.14/36.43)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     538.18|     210|     651|    1105|    1335|       6
---------------------------------------------------------------------------
 1105- 1327 (335.03/257.15)	SAEFVGWVGQaTDRgPWVPDlNYYGALVRRLIDTFS.EPRQQWSRKTDlrfVEFNNFQTHALYSICIELMSLPVGVVDVG..NALVTLVTHW....HSLVDK.NTVMY.WVNAIG.LIFSALPISYMEPFYQTILTTLCSDNMNSINTDVSNKLDFEKRSKLMEDCyPARILA.LCHAVWLHStsgyLQLLPQALRSTWIPHVRSEGQFLYVChLVAPFLQRFYqERTKFTMDI
 1408- 1467 (39.90/10.87)	.......................................................................................................................................................................PIKLLG.IQMVVWLQR....LPIFGETAQHFWLAVTKLGDPVMTFS.LYFPALFPFF.GTAALDMAI
 1490- 1552 (49.29/18.21)	...........................................................................................................W.WVHTAG..VSGQL..SH..PLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDL....VLGdLCGICWL.....................................................
 1760- 1881 (113.96/61.12)	SVDLVDQVVE.TDQ.EWRRS.RYLSDEWNRLKNLCSkEIGEKIKRKEP...VDGNSTLPDSLTDKLQKLTVDQIRALSVGqiKQLRLLIDHEmeksYKLVENlEAVRFkALSQIGnLVHNSVPVSENE..........................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.70|      22|      82|     559|     590|       7
---------------------------------------------------------------------------
  522-  543 (36.50/30.45)	YPNGAVSEVKLRPLKLEFLDSV
  569-  590 (41.20/19.43)	WPSPALVETYCRMLTYPDLEIL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06220 with Med23 domain of Kingdom Metazoa
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