<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06205
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVNHGLVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRYFFPFNFFVYGNEFLNFSVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRLTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHDSLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS |
Length | 1314 |
Position | Tail |
Organism | Trichinella britovi (Parasitic roundworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia>
Trichinellida> Trichinellidae> Trichinella.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.012 |
Instability index | 43.41 |
Isoelectric point | 6.01 |
Molecular weight | 149443.62 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP06205
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 235.87| 75| 133| 1037| 1120| 1
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1037- 1120 (116.37/96.58) EIQQNAFIRicsPSGTHPHPEWSHLqkfILSVEVLEkmKEQANNFTVIrPGQLSLKCN..QSEMKF...FLNESNLS.SVMFKFFRD.END
1173- 1254 (119.50/73.29) NIQQHAYVE...SSTAYWIPEMCFL...IPSPQLVP..TTYLSRATLM.PGGLAIVANvvQKKMLFwikFVRVADPShCVAFPFLYDgENN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.91| 25| 133| 707| 769| 2
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63- 90 (40.63/10.72) RKISIAQFA...HSARQLfvrLYAILKWARC
719- 746 (40.28/65.40) RKITILSCTvgnESARKC...LDDVLSGVRC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 96.69| 27| 133| 425| 455| 3
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425- 451 (50.74/32.35) PDSS..FTETLDLSMNLFTGKFVCRLPAF
497- 525 (45.95/20.43) NFSVriFVNRIDHTMRFFTLKSCETLPAF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 167.81| 47| 656| 229| 278| 4
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229- 278 (77.12/62.02) LPRTPWTllnLRILVSDP.....RVT.DGSDILSSLQLSFLHHLIQSRLNVSKEPI
850- 872 (21.01/ 7.51) .................................SSAALQALTTLPDTIFRVGSEHT
886- 935 (69.68/47.79) LPTGPDT...VRLLCKDHlclemRFTfSGSVFMRDCGSAF..GLPQMK.SVKYVPI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.20| 18| 139| 672| 696| 14
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288- 305 (34.45/17.82) FCLSAQLDI.LCCQAYRLI
677- 695 (28.75/22.63) FGLPKGLAIgLSCDRHRVV
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