<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06203

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRYFFPFNFFVYGNEFLNFSVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRLTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHDSLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1309
PositionTail
OrganismTrichinella britovi (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.012
Instability index43.62
Isoelectric point5.99
Molecular weight148923.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06203
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.87|      75|     133|    1032|    1115|       1
---------------------------------------------------------------------------
 1032- 1115 (116.37/98.04)	EIQQNAFIRicsPSGTHPHPEWSHLqkfILSVEVLEkmKEQANNFTVIrPGQLSLKCN..QSEMKF...FLNESNLS.SVMFKFFRD.END
 1168- 1249 (119.50/74.40)	NIQQHAYVE...SSTAYWIPEMCFL...IPSPQLVP..TTYLSRATLM.PGGLAIVANvvQKKMLFwikFVRVADPShCVAFPFLYDgENN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      25|     133|     702|     764|       2
---------------------------------------------------------------------------
   63-   90 (40.63/10.10)	RKISIAQFA...HSARQLfvrLYAILKWARC
  714-  741 (40.28/61.52)	RKITILSCTvgnESARKC...LDDVLSGVRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.69|      27|     133|     420|     450|       3
---------------------------------------------------------------------------
  420-  446 (50.74/37.14)	PDSS..FTETLDLSMNLFTGKFVCRLPAF
  492-  520 (45.95/23.44)	NFSVriFVNRIDHTMRFFTLKSCETLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.38|      89|     649|     142|     240|       5
---------------------------------------------------------------------------
  142-  240 (133.25/123.48)	VLTLGTYprlPSVIKREFIRtadISQEEEEC..VLHRLNYVIERRLLPSLL.TLPEGMRNFTVNNGMVtFHVAGEFEA.QLTLLGQ....LPRTPWTllnLRILVSD
  798-  894 (135.13/95.64)	ILSFGVD...NSVLNEEYVY...FNPHSILCghLQHWFNAVRDISALAHLLqASSAALQALTTLPDTI.FRVGSEHTSnQMLYLNRmfsiLPTGPDT...VRLLCKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.09|      23|     457|      92|     116|       7
---------------------------------------------------------------------------
   92-  116 (36.99/25.80)	AKVDLCTGIVCflDQQASMFVDTAD
  558-  580 (41.10/22.53)	AKVNLDFWLVC..NETVSNAIRSAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06203 with Med14 domain of Kingdom Metazoa
Unable to open file!