<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06199

Description Mediator of RNA polymerase II transcription subunit 12-like protein (Fragment)
SequenceLTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEDEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHDEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIEVSNVDFNYFKDSDESKLDFDRIIDFADKKAMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRYTTMSQYSSNVPGQEMNASQRQINYYPPQY
Length2077
PositionKinase
OrganismTrichinella britovi (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.268
Instability index48.11
Isoelectric point6.56
Molecular weight235518.37
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06199
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     163.58|      25|      35|    1915|    1939|       1
---------------------------------------------------------------------------
 1874- 1894 (24.52/11.16)	....QMQM............D.......ARQQLMQE.SMM.EQ...QQI
 1915- 1931 (24.97/11.54)	....................A.......ASQPVMHG.NYS.NY...PGQ
 1932- 1965 (29.32/15.11)	HGGGRMQM.....tsgrnqyA.......AQQPAQPPfNCSpNY...NAQ
 1970- 2007 (24.60/11.23)	QNAGQMRMsqtdvigqsnvrY.......TQQPNAIG...S.SYqmqSQQ
 2008- 2031 (33.75/18.75)	TLRAPAGY............V.......AQQANPMY.AAP.NT...P.Q
 2032- 2061 (26.43/12.73)	YQAAQQQ..............nvsmypvSRYTTMSQ.YSS.NV...PGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.47|      19|      42|    1684|    1705|       2
---------------------------------------------------------------------------
 1666- 1693 (23.63/14.06)	ETSD...SDKLT.......terlksngpVAISGGTLVS
 1694- 1731 (14.84/15.89)	EFSDqvqSPRTTkararkstrgrktssrVTVSSNVALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     305.15|      71|      86|     535|     605|       3
---------------------------------------------------------------------------
  502-  530 (33.35/12.37)	..............................PFQKSLFNYLHNQAPNLGE................................MCS........SSEI..KPF
  535-  605 (123.47/65.66)	LLFSRLIESDIFSHDQYVS..TLVSSGDLIPNGANIFYPLQNQCSSAAVENVS.....................NTQPAVLMSSNF.....FSEQF..KPI
  623-  694 (55.11/25.24)	LDFDRIID...FADKKAMSsdT...................DSCSSKRVPKLSkhyfnvlhfpvpqddqyrhecNQRQLLLFGSN.......SDQYsrKHI
  732-  799 (93.22/47.78)	CSLSRKIQNLVF.YDQF.A..VMDCCCDAGIAQFNSFISGQSNC.LPTLENFD.....................FLLGLLEESSNFislveFVE.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.02|      27|      28|     885|     911|       4
---------------------------------------------------------------------------
  850-  878 (34.28/19.98)	.CNIWRSLL..LYVKSKTVVnsfsaERCVWVY
  885-  911 (53.79/35.97)	CCSYIRSLHADLYLNSRDCI.....QRCLCVE
  916-  939 (41.95/26.26)	CCNDLRTLLADV...SQDIM.....LDVLFQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.90|      40|      85|    1329|    1381|       6
---------------------------------------------------------------------------
 1329- 1378 (47.63/66.36)	PYWLVAPLISRLPSFVQgRVlKAAVSILenCqarrDRNlfVQSSSLLAHQ
 1395- 1434 (68.27/41.06)	REGLLSSLLKQIQEFVM.RV.KEDPYIL..C....DRD..IVSEMLDALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.25|      53|      67|    1482|    1537|       7
---------------------------------------------------------------------------
 1482- 1537 (83.72/53.92)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRIYNNviKKLKVKEI..G.DRQVPSLR
 1550- 1606 (81.53/43.50)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQIIGK..EKLNPWEIieGyNRENIGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.46|      12|      37|    1148|    1159|       8
---------------------------------------------------------------------------
 1148- 1159 (19.47/11.88)	ELKSKENFDTKR
 1187- 1198 (19.24/11.64)	ELICRQEWTKRK
 1199- 1210 (20.75/13.24)	FLHSTDLFDPKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.45|      70|     190|     102|     196|       9
---------------------------------------------------------------------------
   15-   98 (104.30/47.77)	PLLNEY.ESLRS.QRFDENLED..YFIKLTqsyNAIVNKKAEINALqdsykKKSGFKEP.SIW.HLAAKpkgqdtWFKDL.SGNKPLSALG
  102-  178 (102.15/100.02)	PFLNKKdEILYTlAEFNVPMVRvvWFLKMT...NAHIAQQQECGKM.....KKKHMSDPfADWtHLVMK......YLRDLcSKLGEFFSLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.17|      34|     190|    1249|    1284|      11
---------------------------------------------------------------------------
 1211- 1236 (34.34/18.56)	..........LLNPLVNQTQAQRLLRMITRSDSEIL
 1249- 1284 (50.58/38.59)	LISKVLDSltIMNLWVSQMDLQLLLKQVANSQSESL
 1286- 1304 (20.25/ 7.93)	LVDTIAKS..CMEVFQPQATL...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     110.82|      18|      18|    1760|    1777|      12
---------------------------------------------------------------------------
 1760- 1776 (26.60/13.74)	....VAMTG....GPSGAVPPYGQG
 1777- 1796 (19.70/ 8.13)	QmwsIGNVQ....SASTAVPP.TQY
 1797- 1815 (20.41/ 8.71)	Q..sRNFTG....AQMTPVQSSSGK
 1834- 1855 (22.40/10.33)	Q...MMTTAhiqaAPLATGQPYHQQ
 1856- 1872 (21.72/ 9.77)	Q...LHSIG....QVDPMVAPMHQ.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06199 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGI
2) IGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPP
3) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1689
1781
1628
1744
1955
1657










Molecular Recognition Features






MoRF SequenceStartStop




1) YYPPQY
2072
2077