<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06198

Description Proteasome subunit beta type-1
SequenceMAESSMNAVEQLLFDAWSECWPDIIFMKQLRQRIEITNQNIEQLSSLLLYYVTLSEMPNRLMLKYIRFCLDTQVVPCVAFLNVVNSYRCYEKVGCINEILVLVIYCLDKLNCDFCDADVCVRTSILVMNTVLWILAYVEYLLTGNNFPPLAHLLSLVFTLKENKFVQFCNYFVCWELSEFHDQIKVSIVNIKVKIEENRHSFPADLLDNMLTFLSFLDIEKDSYDNLFSANPNEILAKSVRASDSRIPSVVISLSGIFAHVQSMKGIAAMVEALKVAKDIQGESWLNILHDLIMGGILQQHDDSTTLPFSVSSSYLYLRIPRLLSQLVAEGIPKETLLGSLKRIATSEAVLNVSDTKARCNTLQAFLNVLSELGILQESEKDTLMAIRDEMRKELYVQEGQPTINLVLRAEFTLQSIVKAFDAHQALERWPQMLNTMMSGKSLLYICAAAISIDQLNLLAERLIKITETYKEVVPVGEDAQKSVPPSHDLFDMSFLLLHRLSQYYSTTTCLRPGDPFFKTWYFSSAIDLVRNMFDPEDLPQLLKNVPMDLELASDVLSRLRVGQPGWLNIRTWYCIIDLIPSIVQVVLNEVLLDTISIEELKHIFSGLLFLNIHGVSCMCSPLLCFAQYVALQKTDEATKLASSLFSFFESITPSDAERNRQTDRQTFMVNSAKKLFSTYRELPVTLMHVLRMNRAPAQLNHSSDDHFPVIGKPENIRSFFAASERVGYLTAALIARIIVLVESEQYDSWLSAFIEALQKVNTMQGMEKWCNLNLACCFIRPKECTLALIPLLSNYVLHDDRDLFCVAPRGNILAFFLVKLYLIALRYTTPTAAVDKAETTEFSVDEYSVQNDTNSSTADRSAVIASLRELFSCKFEVVRSGELCPTVAFVSNFLYCLSEYSTPEAELIKNEVPMHLIFSLLRADPDILSMRTVLRLFDLKVDMVLFVNIAITAAVKVETEFTHCSRLRYSFWFLFQFEISITTTSGSRKKPYLATITDLVLMIGHPTSPSSYQRVCYQLKCFCDINFLLSDPAGDPVIQCGTDYVAFHFRTRQAFTGKAFVKGHYLSPECQIGWNSTQSATGQSSDGGTIWIKHGRCGMHRLRTTNPHGVQFSTVIVVSFHPVFITKMDRAYNVKCEYLETQKSITPITVTQIAQSFPEPSCSYTIRKDELDGEVLKYARVGQQVVHRWECETSVYGMLVHSCFVEDGQGRRVMVIDEQGCHTDRLLLGDPTYVEALNVAYRESSVFKFADRIAVRFICQIRLCLRTNEGCAGITPPACPSPVPDALERNNLRREKRAATNDMIADLVSQTVYVLDDTELNDYTQLEEPISEENHKQSSTVCISPIAVGILGSCLTITVLITSMLMIVFGIRRRSGVHSTATVVPTLSNKETMEFRHQLADHFTMESVRNFKKAWQSKNENALSDRFNPYTENGGTCAGIAGKDFVILSGDTRLSASSMVVMSRTAPKVYRLTPKVYMTGTGFQGDMIQLVKVLRTRIQQYLFTFNEYMDIHAAAQLLSRTLYFRRFFPYYVGAIIGGIDRDGRGVLYSYDPVGTIEELPYSAQGEGSYLIEPFFDNQIGWKTQPEQTKQPLSKERAQQLMHDAFISTIEREKSTGDAVQMVVLHGDRVEEHILKMLNKDDTTLNATSTPTSVEDIRHNLVQNDRPQIFVPPFFSNIFNKGATAAETQENAAKAGIPPVPVRKLPELQESQHPMQTKMMLPKTALPKYQPYFVMPPFLQQRAQFNEQPQNPYSNGPPQTPAWKNFSNRSNFNQRISTSAIEKPSQQWSQQSTDGAAPPPPPPPPPVQLQQENNLYTSQQKKNNFQMPFQFPILQPYPFWSLLQNIQSNNMHNPSPNGPTPPRTYSVDKGKLQNQNLFENGMNFIPSLYPTNNIRPWPMVNSQPNAMPMMPNSRPSETLFQQFDPQSGLFFEKPKIPMQPPPPPPPPPAPRPVLTKQFQYPVPQFELPRPKPTPPTFILRTQLPPTANFKTVNEMEDKQQHQHTQMINYLDRTNSIVNPETRPVQYQMEPPLLNVDDLQQPLKASGYYHQPSSSINNDSSTYMLSLEQSPINFCNPLEFNEQVLASLNLKRVDYFIANMSCSSVFFQCSLQTTFVRRCAGADQVFDESTVNCNYRHSVKSCLEYDHVLHCTIKNQCLSDEYACCAAPQQCIPYAKRCDGIVDCADGEDENNCPTCSINEFPCLIGGTCIPMERRCNGMPDDCFDNSNADEKYCEYCGVGKFYCYKSDPNYEYSCIDANQRCDGNAKVLNFCFAKINDKVYLENNGVTETKTVPTALMKYTKESFFNIIRPHDLVQFLNQENIFLQINAFNKELHKRANSINERQIVDDPDIDIKIISTDPDCATPMPFVQLVGTFPTSVVPLSGFGYQPDDIENLRKLSEGAVSRQPHCGDYLSLSFSVAVLDQIESVHNPSLITSKPETSIASLVFREWPTTGHFGTSVARALERNPTSWELYTLASYYWRAVGNSTEAVHCLRSAVYFVPRNQIVIPMLSLLNVLGHGNRLADAAIVADMTVAMNNSLGALITVSHVYAATSQYKKASTILKLLMLMPMSNVLRSVAENYVAAIKCHEKLENALQEQHTNLNSLLDELDSFKELLEDGQALLSNLDTVEDRESVLNSEMLYNYITYSPVPGLDCRLKSDASGKLAMKCDAVSHEYERHIENAENKQIRKGKQLSPKMLEDGVAEEEEEDASEEFDDLPLYPLDVGVKFPSQWNLADDKPNYSDANSPSSTSSETCWKIPENPPSLFIHSDSKGVKVKEFWKIYVKFREGFAAESLVEQRPMCKPFMTNVNIVQLPSGDRLFELYKLVNVYESDDDIIRKVDPALREHVQQMIGPLQNPEHELGQFLFTMIKYRMGPTWLMFNLAALYWRMLNMYGEAFACLCVALNDPDGVAYNDIALTQLSVLTHQIGGQLADAIDLAEKAIQVDNSEPDSHHLLGYYLTLNHSYSSAVEHLTLSLELEPKSRREIVQLLRAARLLDQGVENLPCFVEKLNRRWSETSNSCGQRNSFNEMIMKSSSSSEELCERVRRQQSIPLEEELDADDDYEPALSLADGSYVQPEVERGRKSTKRATFVDVAVQIPNEELENVRPSAPPPPPPPLPSPPHRHVARLQKDTRLPAVLPELPLHIYDARPVVVDHVHHTLAECQQRLRNFNFDSSISMWLSPQSKGLDVGKLLHFEVPPIEEEFLEPICPTDFAGNMWTMDHLAGFTRRDESAVDYKPEKGLAEVLLSLIPNRAESLQMVATRIAHAMQNPSNDIWLCSLVASVYWRTIGNSSMAIDCLRHSIAYAPTSMKDLGWISLANVYQRSGWFRSALIVAGAALRLSPKLVIIHFILANTYASLGDWQRALAFYYSTVLLQENFEPAKERMHALLTEVQSVQDAPQTSDVCFFCLESKEESKNSNWLNPCLCCGSTKWVHENCLQRWIDVMQMGDSLTPVQCTQCGYQYRLRYPAFPLPMKLLIKVDQAISYVCPVLTGAFVFGSIYWIAVTFGGVTFIQVFGDADAFEILSRLHPALLFVLFPAIPISLMSLQLFHWENSVAAMFERLLLPRQNPPSASVEVAHSFTRSICYAVLMPTIASWVGDILLGNVISSSFYRTLAGGLLTMAVKSICEIYFKYQNVSRNRHRQILNGPLSDIAELPSNGFDECANEDEIELDILIEGEKFISTKWKKKKQCSRWSIPTMFMSKSRFSLLSLLLFEKGQVLKLCDFGSAFLQSEGHTTSNPISSSWMAPEVLSGSSDRDEKSDVYSWAICVWEMYSRQHPFGDVTNSNSIYWMLLEGILGYGTDPTSMYHGNSVHHDLPDTSVPLHCIKKSVEMIDTFQYRGSLTSLLSLFDWPSYVPSEEFEDTAQEMDEVDDM
Length3880
PositionTail
OrganismTrichinella spiralis (Trichina worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.184
Instability index47.07
Isoelectric point5.45
Molecular weight438903.10
Publications









Function






Annotated function


GO - Cellular Component
extracellular region	GO:0005576	IEA:InterPro
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
proteasome core complex	GO:0005839	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
chitin binding	GO:0008061	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
proteolysis involved in cellular protein catabolic process	GO:0051603	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06198
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     242.97|      33|      33|    1722|    1754|       1
---------------------------------------------------------------------------
 1722- 1745 (37.84/16.61)	....................................PKTALPK.YQ........PYFVMPPF..LQQ....RAQF
 1746- 1778 (42.93/20.16)	N..EQPQNPYS......................ngpPQT..PA.WK........NFSNRSNF...NQ....RIST
 1779- 1816 (27.58/ 9.44)	SaiEKPSQQWS...................................qqstdgaaPPPPPPPP..PVQlqqeNNLY
 1817- 1848 (25.70/ 8.13)	T..SQ.......................qkknnfqmP.FQFPI.LQ........PY....PFwsLLQ....NIQS
 1849- 1878 (31.84/12.42)	N..NM.HNPSP....................ngptpPRT................YSVDKGK..LQN....QNLF
 1901- 1954 (40.15/18.22)	N..SQPNA...mpmmpnsrpsetlfqqfdpqsglffEKPKIP..MQ........PPPPPPPP..PAP....RPVL
 1955- 1989 (36.92/15.96)	T..KQFQYPVP.....................qfelPR...PKpTP........PTFILRTQ..LPP....TANF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.12|      41|     145|    3020|    3060|       2
---------------------------------------------------------------------------
 3020- 3060 (71.77/46.21)	TSNSCGQR.NSFN...EMIMKSSSSSEEL.CERVRRQQSIPLEEEL
 3163- 3208 (60.36/37.50)	TLAECQQRlRNFNfdsSISMWLSPQSKGLdVGKLLHFEVPPIEEEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.55|      28|     671|     105|     132|       4
---------------------------------------------------------------------------
  105-  132 (52.49/32.93)	YCLDKLNCDFCDADVCVRTSI.LVMNTVL
  770-  798 (49.06/30.24)	WCNLNLACCFIRPKECTLALIpLLSNYVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     396.96|     113|     145|    3273|    3394|       5
---------------------------------------------------------------------------
 2878- 2923 (27.71/ 8.96)	..PT...WL..MFNLAALYWRMLNMYGEAFACLcvalndPDGVAYNDIALTQL..................................................................................
 3273- 3394 (182.25/156.54)	QNPSNDIWL..CSLVASVYWRTIGNSSMAIDCL......RHSIAYAPTSMKDLGWiSLANVYQRSGWFRSALIVAGAALRLSPKLVIIHFILANTYaslgdWqraLAFYYSTVLLQENFEPAK.....ERMHALL
 3418- 3537 (186.99/135.84)	EESKNSNWLnpCLCCGSTKWVHENCLQRWIDVM......QMGDSLTPVQCTQCGY.QYRLRYPAFPLPMKLLIKVDQAISYVCPVLTGAFVFGSIY.....W...IAVTFGGVTFIQVFGDADafeilSRLHPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.72|      32|     140|    2116|    2147|       6
---------------------------------------------------------------------------
 2100- 2132 (30.79/12.66)	........SCssvffqcsLQTT..FV................................RRCAG.ADQVFDESTVN...C
 2133- 2164 (58.66/30.83)	NYRHSVK.SC........LEYD..HV................................LHCTI.KNQCLSDEYAC...C
 2172- 2233 (25.90/ 9.47)	PYA...K.RC...........D..GIvdcadgedenncptcsinefpcliggtcipmeRRCNGmPDDCFDNSNADekyC
 2234- 2262 (32.37/13.69)	EYCGVGKfYC........YKSDpnYE................................YSCID.ANQRCD.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.20|      47|      98|    1404|    1452|      10
---------------------------------------------------------------------------
 1404- 1452 (76.20/57.61)	FTMESVRNFKKAWQSKNENALSDRFNPYtENGGTCAGI..AGKDfVILSGD
 1504- 1552 (81.00/51.67)	FTFNEYMDIHAAAQLLSRTLYFRRFFPY.YVGAIIGGIdrDGRG.VLYSYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.75|      17|     671|    3076|    3097|      11
---------------------------------------------------------------------------
 1066- 1082 (33.97/16.03)	YLSPECQIGWNSTQSAT
 3077- 3093 (30.78/21.13)	YVQPEVERGRKSTKRAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.77|      15|     146|    3102|    3121|      12
---------------------------------------------------------------------------
 1269- 1283 (31.83/11.16)	NEGCAGI...TPPACPSP
 3103- 3120 (25.95/16.61)	NEELENVrpsAPPPPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.97|      80|     408|    2516|    2611|      13
---------------------------------------------------------------------------
 2516- 2611 (112.51/129.66)	VLGH..GNRLADAAIVADMTVAMNNS.......LGALITVSHvyaatsQYKKASTILKL.LMLMPMSNvlRSVaenyVAAIKCHEKLENALQeqhtNLNSLLDELD
 2925- 3014 (119.47/92.05)	VLTHqiGGQLADAIDLAEKAIQVDNSepdshhlLGYYLTLNH......SYSSAVEHLTLsLELEPKSR..REI....VQLLRAARLLDQGVE....NLPCFVEKLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.18|      68|     965|    2662|    2734|      24
---------------------------------------------------------------------------
 2662- 2734 (108.35/92.44)	ASGKLAMKCDAVSHEYERHIENAENKQirkgKQLSPKMLEDgVAEEEEE..DASEEFDDLPLYPLDVGVKFPS.QW
 3621- 3691 (108.83/77.30)	AGGLLTMAVKSICEIYFKYQNVSRNRH....RQILNGPLSD.IAELPSNgfDECANEDEIELDILIEGEKFIStKW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06198 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAETQENAAKAGIPPVPVRKLPELQESQHPMQTKMMLP
2) AQFNEQPQNPYSNGPPQTPAWKNFSNRSNFNQRISTSAIEKPSQQWSQQSTDGAAPPPPPPPPPVQLQQENNLYTSQQKK
3) IENAENKQIRKGKQLSPKMLEDGVAEEEEEDASEEF
4) LCERVRRQQSIPLEEELDADDDYEPALSLADGSYVQPEVERG
5) LFFEKPKIPMQPPPPPPPPPAPRPVLTKQFQYPVPQFEL
6) NEELENVRPSAPPPPPPPLPSPPHRHVARLQKD
7) NIRPWPMVNSQPNAMPMMPNSRPSETLFQQFDPQ
8) QNIQSNNMHNPSPNGPTPPRTYSVDKGKLQNQNLFENGMNFI
9) RPKPTPPTFILRTQLPPTANFKTVNEMEDKQQHQHTQMINYLDRTN
1685
1743
2681
3044
1929
3103
1893
1844
1969
1722
1822
2716
3085
1967
3135
1926
1885
2014










Molecular Recognition Features






MoRF SequenceStartStop




NANANA