<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06198

Description Proteasome subunit beta type-1
SequenceMAESSMNAVEQLLFDAWSECWPDIIFMKQLRQRIEITNQNIEQLSSLLLYYVTLSEMPNRLMLKYIRFCLDTQVVPCVAFLNVVNSYRCYEKVGCINEILVLVIYCLDKLNCDFCDADVCVRTSILVMNTVLWILAYVEYLLTGNNFPPLAHLLSLVFTLKENKFVQFCNYFVCWELSEFHDQIKVSIVNIKVKIEENRHSFPADLLDNMLTFLSFLDIEKDSYDNLFSANPNEILAKSVRASDSRIPSVVISLSGIFAHVQSMKGIAAMVEALKVAKDIQGESWLNILHDLIMGGILQQHDDSTTLPFSVSSSYLYLRIPRLLSQLVAEGIPKETLLGSLKRIATSEAVLNVSDTKARCNTLQAFLNVLSELGILQESEKDTLMAIRDEMRKELYVQEGQPTINLVLRAEFTLQSIVKAFDAHQALERWPQMLNTMMSGKSLLYICAAAISIDQLNLLAERLIKITETYKEVVPVGEDAQKSVPPSHDLFDMSFLLLHRLSQYYSTTTCLRPGDPFFKTWYFSSAIDLVRNMFDPEDLPQLLKNVPMDLELASDVLSRLRVGQPGWLNIRTWYCIIDLIPSIVQVVLNEVLLDTISIEELKHIFSGLLFLNIHGVSCMCSPLLCFAQYVALQKTDEATKLASSLFSFFESITPSDAERNRQTDRQTFMVNSAKKLFSTYRELPVTLMHVLRMNRAPAQLNHSSDDHFPVIGKPENIRSFFAASERVGYLTAALIARIIVLVESEQYDSWLSAFIEALQKVNTMQGMEKWCNLNLACCFIRPKECTLALIPLLSNYVLHDDRDLFCVAPRGNILAFFLVKLYLIALRYTTPTAAVDKAETTEFSVDEYSVQNDTNSSTADRSAVIASLRELFSCKFEVVRSGELCPTVAFVSNFLYCLSEYSTPEAELIKNEVPMHLIFSLLRADPDILSMRTVLRLFDLKVDMVLFVNIAITAAVKVETEFTHCSRLRYSFWFLFQFEISITTTSGSRKKPYLATITDLVLMIGHPTSPSSYQRVCYQLKCFCDINFLLSDPAGDPVIQCGTDYVAFHFRTRQAFTGKAFVKGHYLSPECQIGWNSTQSATGQSSDGGTIWIKHGRCGMHRLRTTNPHGVQFSTVIVVSFHPVFITKMDRAYNVKCEYLETQKSITPITVTQIAQSFPEPSCSYTIRKDELDGEVLKYARVGQQVVHRWECETSVYGMLVHSCFVEDGQGRRVMVIDEQGCHTDRLLLGDPTYVEALNVAYRESSVFKFADRIAVRFICQIRLCLRTNEGCAGITPPACPSPVPDALERNNLRREKRAATNDMIADLVSQTVYVLDDTELNDYTQLEEPISEENHKQSSTVCISPIAVGILGSCLTITVLITSMLMIVFGIRRRSGVHSTATVVPTLSNKETMEFRHQLADHFTMESVRNFKKAWQSKNENALSDRFNPYTENGGTCAGIAGKDFVILSGDTRLSASSMVVMSRTAPKVYRLTPKVYMTGTGFQGDMIQLVKVLRTRIQQYLFTFNEYMDIHAAAQLLSRTLYFRRFFPYYVGAIIGGIDRDGRGVLYSYDPVGTIEELPYSAQGEGSYLIEPFFDNQIGWKTQPEQTKQPLSKERAQQLMHDAFISTIEREKSTGDAVQMVVLHGDRVEEHILKMLNKDDTTLNATSTPTSVEDIRHNLVQNDRPQIFVPPFFSNIFNKGATAAETQENAAKAGIPPVPVRKLPELQESQHPMQTKMMLPKTALPKYQPYFVMPPFLQQRAQFNEQPQNPYSNGPPQTPAWKNFSNRSNFNQRISTSAIEKPSQQWSQQSTDGAAPPPPPPPPPVQLQQENNLYTSQQKKNNFQMPFQFPILQPYPFWSLLQNIQSNNMHNPSPNGPTPPRTYSVDKGKLQNQNLFENGMNFIPSLYPTNNIRPWPMVNSQPNAMPMMPNSRPSETLFQQFDPQSGLFFEKPKIPMQPPPPPPPPPAPRPVLTKQFQYPVPQFELPRPKPTPPTFILRTQLPPTANFKTVNEMEDKQQHQHTQMINYLDRTNSIVNPETRPVQYQMEPPLLNVDDLQQPLKASGYYHQPSSSINNDSSTYMLSLEQSPINFCNPLEFNEQVLASLNLKRVDYFIANMSCSSVFFQCSLQTTFVRRCAGADQVFDESTVNCNYRHSVKSCLEYDHVLHCTIKNQCLSDEYACCAAPQQCIPYAKRCDGIVDCADGEDENNCPTCSINEFPCLIGGTCIPMERRCNGMPDDCFDNSNADEKYCEYCGVGKFYCYKSDPNYEYSCIDANQRCDGNAKVLNFCFAKINDKVYLENNGVTETKTVPTALMKYTKESFFNIIRPHDLVQFLNQENIFLQINAFNKELHKRANSINERQIVDDPDIDIKIISTDPDCATPMPFVQLVGTFPTSVVPLSGFGYQPDDIENLRKLSEGAVSRQPHCGDYLSLSFSVAVLDQIESVHNPSLITSKPETSIASLVFREWPTTGHFGTSVARALERNPTSWELYTLASYYWRAVGNSTEAVHCLRSAVYFVPRNQIVIPMLSLLNVLGHGNRLADAAIVADMTVAMNNSLGALITVSHVYAATSQYKKASTILKLLMLMPMSNVLRSVAENYVAAIKCHEKLENALQEQHTNLNSLLDELDSFKELLEDGQALLSNLDTVEDRESVLNSEMLYNYITYSPVPGLDCRLKSDASGKLAMKCDAVSHEYERHIENAENKQIRKGKQLSPKMLEDGVAEEEEEDASEEFDDLPLYPLDVGVKFPSQWNLADDKPNYSDANSPSSTSSETCWKIPENPPSLFIHSDSKGVKVKEFWKIYVKFREGFAAESLVEQRPMCKPFMTNVNIVQLPSGDRLFELYKLVNVYESDDDIIRKVDPALREHVQQMIGPLQNPEHELGQFLFTMIKYRMGPTWLMFNLAALYWRMLNMYGEAFACLCVALNDPDGVAYNDIALTQLSVLTHQIGGQLADAIDLAEKAIQVDNSEPDSHHLLGYYLTLNHSYSSAVEHLTLSLELEPKSRREIVQLLRAARLLDQGVENLPCFVEKLNRRWSETSNSCGQRNSFNEMIMKSSSSSEELCERVRRQQSIPLEEELDADDDYEPALSLADGSYVQPEVERGRKSTKRATFVDVAVQIPNEELENVRPSAPPPPPPPLPSPPHRHVARLQKDTRLPAVLPELPLHIYDARPVVVDHVHHTLAECQQRLRNFNFDSSISMWLSPQSKGLDVGKLLHFEVPPIEEEFLEPICPTDFAGNMWTMDHLAGFTRRDESAVDYKPEKGLAEVLLSLIPNRAESLQMVATRIAHAMQNPSNDIWLCSLVASVYWRTIGNSSMAIDCLRHSIAYAPTSMKDLGWISLANVYQRSGWFRSALIVAGAALRLSPKLVIIHFILANTYASLGDWQRALAFYYSTVLLQENFEPAKERMHALLTEVQSVQDAPQTSDVCFFCLESKEESKNSNWLNPCLCCGSTKWVHENCLQRWIDVMQMGDSLTPVQCTQCGYQYRLRYPAFPLPMKLLIKVDQAISYVCPVLTGAFVFGSIYWIAVTFGGVTFIQVFGDADAFEILSRLHPALLFVLFPAIPISLMSLQLFHWENSVAAMFERLLLPRQNPPSASVEVAHSFTRSICYAVLMPTIASWVGDILLGNVISSSFYRTLAGGLLTMAVKSICEIYFKYQNVSRNRHRQILNGPLSDIAELPSNGFDECANEDEIELDILIEGEKFISTKWKKKKQCSRWSIPTMFMSKSRFSLLSLLLFEKGQVLKLCDFGSAFLQSEGHTTSNPISSSWMAPEVLSGSSDRDEKSDVYSWAICVWEMYSRQHPFGDVTNSNSIYWMLLEGILGYGTDPTSMYHGNSVHHDLPDTSVPLHCIKKSVEMIDTFQYRGSLTSLLSLFDWPSYVPSEEFEDTAQEMDEVDDM
Length3880
PositionTail
OrganismTrichinella spiralis (Trichina worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.184
Instability index47.07
Isoelectric point5.45
Molecular weight438903.10
Publications









Function






Annotated function


GO - Cellular Component
extracellular region	GO:0005576	IEA:InterPro
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
proteasome core complex	GO:0005839	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
chitin binding	GO:0008061	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
proteolysis involved in cellular protein catabolic process	GO:0051603	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06198
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     242.97|      33|      33|    1722|    1754|       1
---------------------------------------------------------------------------
 1722- 1745 (37.84/16.61)	....................................PKTALPK.YQ........PYFVMPPF..LQQ....RAQF
 1746- 1778 (42.93/20.16)	N..EQPQNPYS......................ngpPQT..PA.WK........NFSNRSNF...NQ....RIST
 1779- 1816 (27.58/ 9.44)	SaiEKPSQQWS...................................qqstdgaaPPPPPPPP..PVQlqqeNNLY
 1817- 1848 (25.70/ 8.13)	T..SQ.......................qkknnfqmP.FQFPI.LQ........PY....PFwsLLQ....NIQS
 1849- 1878 (31.84/12.42)	N..NM.HNPSP....................ngptpPRT................YSVDKGK..LQN....QNLF
 1901- 1954 (40.15/18.22)	N..SQPNA...mpmmpnsrpsetlfqqfdpqsglffEKPKIP..MQ........PPPPPPPP..PAP....RPVL
 1955- 1989 (36.92/15.96)	T..KQFQYPVP.....................qfelPR...PKpTP........PTFILRTQ..LPP....TANF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.12|      41|     145|    3020|    3060|       2
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 3020- 3060 (71.77/46.21)	TSNSCGQR.NSFN...EMIMKSSSSSEEL.CERVRRQQSIPLEEEL
 3163- 3208 (60.36/37.50)	TLAECQQRlRNFNfdsSISMWLSPQSKGLdVGKLLHFEVPPIEEEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.55|      28|     671|     105|     132|       4
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  105-  132 (52.49/32.93)	YCLDKLNCDFCDADVCVRTSI.LVMNTVL
  770-  798 (49.06/30.24)	WCNLNLACCFIRPKECTLALIpLLSNYVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     396.96|     113|     145|    3273|    3394|       5
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 2878- 2923 (27.71/ 8.96)	..PT...WL..MFNLAALYWRMLNMYGEAFACLcvalndPDGVAYNDIALTQL..................................................................................
 3273- 3394 (182.25/156.54)	QNPSNDIWL..CSLVASVYWRTIGNSSMAIDCL......RHSIAYAPTSMKDLGWiSLANVYQRSGWFRSALIVAGAALRLSPKLVIIHFILANTYaslgdWqraLAFYYSTVLLQENFEPAK.....ERMHALL
 3418- 3537 (186.99/135.84)	EESKNSNWLnpCLCCGSTKWVHENCLQRWIDVM......QMGDSLTPVQCTQCGY.QYRLRYPAFPLPMKLLIKVDQAISYVCPVLTGAFVFGSIY.....W...IAVTFGGVTFIQVFGDADafeilSRLHPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.72|      32|     140|    2116|    2147|       6
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 2100- 2132 (30.79/12.66)	........SCssvffqcsLQTT..FV................................RRCAG.ADQVFDESTVN...C
 2133- 2164 (58.66/30.83)	NYRHSVK.SC........LEYD..HV................................LHCTI.KNQCLSDEYAC...C
 2172- 2233 (25.90/ 9.47)	PYA...K.RC...........D..GIvdcadgedenncptcsinefpcliggtcipmeRRCNGmPDDCFDNSNADekyC
 2234- 2262 (32.37/13.69)	EYCGVGKfYC........YKSDpnYE................................YSCID.ANQRCD.........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.20|      47|      98|    1404|    1452|      10
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 1404- 1452 (76.20/57.61)	FTMESVRNFKKAWQSKNENALSDRFNPYtENGGTCAGI..AGKDfVILSGD
 1504- 1552 (81.00/51.67)	FTFNEYMDIHAAAQLLSRTLYFRRFFPY.YVGAIIGGIdrDGRG.VLYSYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.75|      17|     671|    3076|    3097|      11
---------------------------------------------------------------------------
 1066- 1082 (33.97/16.03)	YLSPECQIGWNSTQSAT
 3077- 3093 (30.78/21.13)	YVQPEVERGRKSTKRAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.77|      15|     146|    3102|    3121|      12
---------------------------------------------------------------------------
 1269- 1283 (31.83/11.16)	NEGCAGI...TPPACPSP
 3103- 3120 (25.95/16.61)	NEELENVrpsAPPPPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.97|      80|     408|    2516|    2611|      13
---------------------------------------------------------------------------
 2516- 2611 (112.51/129.66)	VLGH..GNRLADAAIVADMTVAMNNS.......LGALITVSHvyaatsQYKKASTILKL.LMLMPMSNvlRSVaenyVAAIKCHEKLENALQeqhtNLNSLLDELD
 2925- 3014 (119.47/92.05)	VLTHqiGGQLADAIDLAEKAIQVDNSepdshhlLGYYLTLNH......SYSSAVEHLTLsLELEPKSR..REI....VQLLRAARLLDQGVE....NLPCFVEKLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.18|      68|     965|    2662|    2734|      24
---------------------------------------------------------------------------
 2662- 2734 (108.35/92.44)	ASGKLAMKCDAVSHEYERHIENAENKQirkgKQLSPKMLEDgVAEEEEE..DASEEFDDLPLYPLDVGVKFPS.QW
 3621- 3691 (108.83/77.30)	AGGLLTMAVKSICEIYFKYQNVSRNRH....RQILNGPLSD.IAELPSNgfDECANEDEIELDILIEGEKFIStKW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06198 with Med24 domain of Kingdom Metazoa
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