<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06197

Description Proteasome subunit beta type-1
SequenceMAESSMNAVEQLLFDAWSECWPDIIFMKQLRQRIEITNQNIEQLSSLLLYYVTLSEMPNRLMLKYIRFCLDTQVVPCVAFLNVVNSYRCYEKVGCINEILVLVIYCLDKLNCDFCDADVCVRTSILVMNTVLWILAYVEYLLTGNNFPPLAHLLSLVFTLKENKFVQFCNYFVCWELSEFHDQIKVSIVNIKVKIEENRHSFPADLLDNMLTFLSFLDIEKDSYDNLFSANPNEILAKSVRASDSRIPSVVISLSGIFAHVQSMKGIAAMVEALKVAKDIQGESWLNILHDLIMGGILQQHDDSTTLPFSVSSSYLYLRIPRLLSQLVAEGIPKETLLGSLKRIATSEAVLNVSDTKARCNTLQAFLNVLSELGILQESEKDTLMAIRDEMRKELYVQEGQPTINLVLRAEFTLQSIVKAFDAHQALERWPQMLNTMMSGKSLLYICAAAISIDQLNLLAERLIKITETYKEVVPVGEDAQKSVPPSHDLFDMSFLLLHRLSQYYSTTTCLRPGDPFFKTWYFSSAIDLVRNMFDPEDLPQLLKNVPMDLELASDVLSRLRVGQPGWLNIRTWYCIIDLIPSIVQVVLNEVLLDTISIEELKHIFSGLLFLNIHGVSCMCSPLLCFAQYVALQKTDEATKLASSLFSFFESITPSDAERNRQTDRQTFMVNSAKKLFSTYRELPVTLMHVLRMNRAPAQLNHSSDDHFPVIGKPENIRSFFAASERVGYLTAALIARIIVLVESEQYDSWLSAFIEALQKVNTMQGMEKWCNLNLACCFIRPKECTLALIPLLSNYVLHDDRDLFCVAPRGNILAFFLVKLYLIALRYTTPTAAVDKAETTEFSVDEYSVQNDTNSSTADRSAVIASLRELFSCKFEVVRSGELCPTVAFVSNFLYCLSEYSTPEAELIKNEVPMHLIFSLLRADPDILSMRTVLRLFDLKVDMVLFVNIAITAAVKVETEFTHCSRLRYSFWFLFQFEISITTTSGSRKKPYLATITDLVLMIGHPTSPSSYQRVCYQLKCFCDINFLLSDPAGDPVIQCGTDYVAFHFRTRQAFTGKAFVKGHYLSPECQIGWNSTQSATGQSSDGGTIWIKHGRCGMHRLRTTNPHGVQFSTVIVVSFHPVFITKMDRAYNVKCEYLETQKSITPITVTQIAQSFPEPSCSYTIRKDELDGEVLKYARVGQQVVHRWECETSVYGMLVHSCFVEDGQGRRVMVIDEQGCHTDRLLLGDPTYVEALNVAYRESSVFKFADRIAVRFICQIRLCLRTNEGCAGITPPACPSPVPDALERNNLRREKRAATNDMIADLVSQTVYVLDDTELNDYTQLEEPISEENHKQSSTVCISPIAVGILGSCLTITVLITSMLMIVFGIRRRSGVHSTATVVPTLSNKETMEFRHQLADHFTMESVRNFKKAWQSKNENALSDRFNPYTENGGTCAGIAGKDFVILSGDTRLSASSMVVMSRTAPKVYRLTPKVYMTGTGFQGDMIQLVKVLRTRIQQYLFTFNEYMDIHAAAQLLSRTLYFRRFFPYYVGAIIGGIDRDGRGVLYSYDPVGTIEELPYSAQGEGSYLIEPFFDNQIGWKTQPEQTKQPLSKERAQQLMHDAFISTIEREKSTGDAVQMVVLHGDRVEEHILKMLNKDDTTLNATSTPTSVEDIRHNLVQNDRPQIFVPPFFSNIFNKGATAAETQENAAKAGIPPVPVRKLPELQESQHPMQTKMMLPKTALPKYQPYFVMPPFLQQRAQFNEQPQNPYSNGPPQTPAWKNFSNRSNFNQRISTSAIEKPSQQWSQQSTDGAAPPPPPPPPPVQLQQENNLYTSQQKKNNFQMPFQFPILQPYPFWSLLQNIQSNNMHNPSPNGPTPPRTYSVDKGKLQNQNLFENGMNFIPSLYPTNNIRPWPMVNSQPNAMPMMPNSRPSETLFQQFDPQSGLFFEKPKIPMQPPPPPPPPPAPRPVLTKQFQYPVPQFELPRPKPTPPTFILRTQLPPTANFKTVNEMEDKQQHQHTQMINYLDRTNSIVNPETRPVQYQMEPPLLNVDDLQQPLKASGYYHQPSSSINNDSSTYMLSLEQSPINFCNPLEFNEQVLASLNLKRVDYFIANMSCSSVFFQCSLQTTFVRRCAGADQVFDESTVNCNYRHSVKSCLEYDHVLHCTIKNQCLSDEYACCAAPQQCIPYAKRCDGIVDCADGEDENNCPTCSINEFPCLIGGTCIPMERRCNGMPDDCFDNSNADEKYCEYCGVGKFYCYKSDPNYEYSCIDANQRCDGNAKVLNFCFAKINDKVYLENNGVTETKTVPTALMKYTKESFFNIIRPHDLVQFLNQENIFLQINAFNKELHKRANSINERQIVDDPDIDIKIISTDPDCATPMPFVQLVGTFPTSVVPLSGFGYQPDDIENLRKLSEGAVSRQPHCGDYLSLSFSVAVLDQIESVHNPSLITSKPETSIASLVFREWPTTGHFGTSVARALERNPTSWELYTLASYYWRAVGNSTEAVHCLRSAVYFVPRNQIVIPMLSLLNVLGHGNRLADAAIVADMTVAMNNSLGALITVSHVYAATSQYKKASTILKLLMLMPMSNVLRSVAENYVAAIKCHEKLENALQEQHTNLNSLLDELDSFKELLEDGQALLSNLDTVEDRESVLNSEMLYNYITYSPVPGLDCRLKSDASGKLAMKCDAVSHEYERHIENAENKQIRKGKQLSPKMLEDGVAEEEEEDASEEFDDLPLYPLDVGVKFPSQWNLADDKPNYSDANSPSSTSSETCWKIPENPPSLFIHSDSKGVKVKEFWKIYVKFREGFAAESLVEQRPMCKPFMTNVNIVQLPSGDRLFELYKLVNVYESDDDIIRKVDPALREHVQQMIGPLQNPEHELGQFLFTMIKYRMGPTWLMFNLAALYWRMLNMYGEAFACLCVALNDPDGVAYNDIALTQLSVLTHQIGGQLADAIDLAEKAIQVDNSEPDSHHLLGYYLTLNHSYSSAVEHLTLSLELEPKSRREIVQLLRAARLLDQGVENLPCFVEKLNRRWSETSNSCGQRNSFNEMIMKSSSSSEELCERVRRQQSIPLEEELDADDDYEPALSLADGSYVQPEVERGRKSTKRATFVDVAVQIPNEELENVRPSAPPPPPPPLPSPPHRHVARLQKDTRLPAVLPELPLHIYDARPVVVDHVHHTLAECQQRLRNFNFDSSISMWLSPQSKGLDVGKLLHFEVPPIEEEFLEPICPTDFAGNMWTMDHLAGFTRRDESAVDYKPEKGLAEVLLSLIPNRAESLQMVATRIAHAMQNPSNDIWLCSLVASVYWRTIGNSSMAIDCLRHSIAYAPTSMKDLGWISLANVYQRSGWFRSALIVAGAALRLSPKLVIIHFILANTYASLGDWQRALAFYYSTVLLQENFEPAKERMHALLTEVQSVQDAPQTSDVCFFCLESKEESKNSNWLNPCLCCGSTKWVHENCLQRWIDVMQMGDSLTPVQCTQCGYQYRLRYPAFPLPMKLLIKVDQAISYVCPVLTGAFVFGSIYWIAVTFGGVTFIQVFGDADAFEILSRLHPALLFVLFPAIPISLMSLQLFHWENSVAAMFERLLLPRQNPPSASVEVAHSFTRSICYAVLMPTIASWVGDILLGNVISSSFYRTLAGGLLTMAVKSICEIYFKYQNVSRNRHRQILNGPLSDIAELPSNGFDECANEDEIGEERG
Length3680
PositionTail
OrganismTrichinella spiralis (Trichina worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.178
Instability index47.55
Isoelectric point5.51
Molecular weight415994.41
Publications









Function






Annotated function


GO - Cellular Component
extracellular region	GO:0005576	IEA:InterPro
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
proteasome core complex	GO:0005839	IEA:InterPro

GO - Biological Function
chitin binding	GO:0008061	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
proteolysis involved in cellular protein catabolic process	GO:0051603	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06197
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     242.97|      33|      33|    1722|    1754|       1
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 1722- 1745 (37.84/13.35)	....................................PKTALPK.YQ........PYFVMPPF..LQQ....RAQF
 1746- 1778 (42.93/16.19)	N..EQPQNPYS......................ngpPQT..PA.WK........NFSNRSNF...NQ....RIST
 1779- 1816 (27.58/ 7.64)	SaiEKPSQQWS...................................qqstdgaaPPPPPPPP..PVQlqqeNNLY
 1817- 1848 (25.70/ 6.59)	T..SQ.......................qkknnfqmP.FQFPI.LQ........PY....PFwsLLQ....NIQS
 1849- 1878 (31.84/10.01)	N..NM.HNPSP....................ngptpPRT................YSVDKGK..LQN....QNLF
 1901- 1954 (40.15/14.64)	N..SQPNA...mpmmpnsrpsetlfqqfdpqsglffEKPKIP..MQ........PPPPPPPP..PAP....RPVL
 1955- 1989 (36.92/12.84)	T..KQFQYPVP.....................qfelPR...PKpTP........PTFILRTQ..LPP....TANF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.12|      41|     145|    3020|    3060|       2
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 3020- 3060 (71.77/54.01)	TSNSCGQR.NSFN...EMIMKSSSSSEEL.CERVRRQQSIPLEEEL
 3163- 3208 (60.36/43.86)	TLAECQQRlRNFNfdsSISMWLSPQSKGLdVGKLLHFEVPPIEEEF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.36|      20|     145|     547|     574|       3
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  551-  573 (31.21/46.28)	ELASDVLSRLRVGQPGwlnIRTW
 1171- 1190 (37.15/17.91)	ELDGEVLKYARVGQQV...VHRW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     396.96|     113|     145|    3273|    3394|       4
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 2878- 2923 (27.71/ 6.86)	..PT...WL..MFNLAALYWRMLNMYGEAFACLcvalndPDGVAYNDIALTQL..................................................................................
 3273- 3394 (182.25/120.61)	QNPSNDIWL..CSLVASVYWRTIGNSSMAIDCL......RHSIAYAPTSMKDLGWiSLANVYQRSGWFRSALIVAGAALRLSPKLVIIHFILANTYaslgdWqraLAFYYSTVLLQENFEPAK.....ERMHALL
 3418- 3537 (186.99/104.65)	EESKNSNWLnpCLCCGSTKWVHENCLQRWIDVM......QMGDSLTPVQCTQCGY.QYRLRYPAFPLPMKLLIKVDQAISYVCPVLTGAFVFGSIY.....W...IAVTFGGVTFIQVFGDADafeilSRLHPAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.55|      30|      99|    2116|    2145|       5
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 2116- 2132 (22.08/ 9.02)	................................................RRCAG.ADQVFDESTVN...C
 2133- 2164 (49.93/31.50)	NYRHSVK.SCLEYD................................hvLHCTI.KNQCLSDEYAC...C
 2172- 2233 (23.38/10.07)	PYA...K.RC...DgivdcadgedenncptcsinefpcliggtcipmeRRCNGmPDDCFDNSNADekyC
 2234- 2269 (25.16/11.50)	EYCGVGKfYCYKSD.......................pnyeyscidanQRCDG.NAKVLN.........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.20|      47|      97|    1404|    1452|       8
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 1404- 1452 (76.20/57.46)	FTMESVRNFKKAWQSKNENALSDRFNPYtENGGTCAGI..AGKDfVILSGD
 1504- 1552 (81.00/51.52)	FTFNEYMDIHAAAQLLSRTLYFRRFFPY.YVGAIIGGIdrDGRG.VLYSYD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.97|      80|     408|    2516|    2611|       9
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 2516- 2611 (112.51/111.79)	VLGH..GNRLADAAIVADMTVAMNNS.......LGALITVSHvyaatsQYKKASTILKL.LMLMPMSNvlRSVaenyVAAIKCHEKLENALQeqhtNLNSLLDELD
 2925- 3014 (119.47/79.30)	VLTHqiGGQLADAIDLAEKAIQVDNSepdshhlLGYYLTLNH......SYSSAVEHLTLsLELEPKSR..REI....VQLLRAARLLDQGVE....NLPCFVEKLN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.77|      15|     144|    3102|    3121|      14
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 1269- 1283 (31.83/10.07)	NEGCAGI...TPPACPSP
 3103- 3120 (25.95/15.06)	NEELENVrpsAPPPPPPP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.94|      56|     120|     790|     849|      16
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  790-  849 (83.32/70.50)	IPL.LSNYVLHDDRDLFCVapRgNILAFFLVKLYLIALRYTTPTAAVdKAET..TEFSVDEYS
  913-  971 (86.63/56.52)	VPMhLIFSLLRADPDILSM..R.TVLRLFDLKVDMVLFVNIAITAAV.KVETefTHCSRLRYS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06197 with Med24 domain of Kingdom Metazoa
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