<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06174

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLQLFFLYFLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKASNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQLEFECCLSDWLVSPILQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQIQQQIQHQQQQQQQLQVQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKVKDRNINQPLLDAISAITKPERQKINLYEYFNFPLYHPDCLKGSCENETARASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length746
PositionTail
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.750
Instability index78.68
Isoelectric point6.85
Molecular weight84971.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06174
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     388.99|      59|      59|     263|     321|       1
---------------------------------------------------------------------------
  123-  168 (78.17/15.66)	QQQQQQQQQQVPGQ..IYSGMR.....APPNAE.....MQP...RLLR.................P............MHQ.P.SVTMHHMH
  169-  230 (61.88/11.02)	QQQAQMGQMGMTQSagIAAAAQ.....QQPQNV.....V...................mllTSGNPPRQAasapsavQLRQPN.DIQQLEFE
  239-  292 (80.90/16.43)	SPILQQLPPAIRQQ..I............LQLP.....PEE.qaEQLKKF.......F...ESRRWQQQQ.......QLHQQQ.QIQQQQQQ
  293-  347 (93.12/19.91)	QQQQQQQQQQIQQQ..IQHQQQ.....QQQQLQ.....VQQqiqHQMHH........V.........AQN.......QMHTQA.VIQQQQQQ
  348-  419 (74.91/14.73)	QQQQQQQQQQ.......QHQQQfasvrQQQQMQmlqpmMQQ...PGAVRFadqsttmL...YSRPPATPV.......MIPQTPaPVQQPPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.58|      16|      45|     432|     449|       2
---------------------------------------------------------------------------
  425-  441 (26.50/13.74)	PMSGQA.aS.PNVNIG...TPY
  477-  498 (17.09/11.98)	SQMSPAanSlPPESIGaehSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.77|      21|      23|     632|     653|       3
---------------------------------------------------------------------------
  632-  653 (31.47/25.52)	PLNIQ.REIGSLESKFRVTIdPS
  656-  677 (31.30/19.95)	PLRSScKFISVLCELLDITL.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.60|      12|      17|     445|     456|       5
---------------------------------------------------------------------------
  445-  456 (24.52/10.87)	SPAGAHMMGPSP
  463-  474 (25.07/11.27)	SPVCHPAATPGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06174 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAA
2) HQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
3) QQQPQNVVMLLTSGNPPRQAASAPSAVQLRQ
78
325
190
188
497
220










Molecular Recognition Features






MoRF SequenceStartStop




NANANA