<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06171

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLQLFFLYFLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKASNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQLEFECCLSDWLVSPILQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQQIQQQIQHQQQQQQQLQVQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQHFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKYVTVFSPDCLKGSCENETARASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length712
PositionTail
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.728
Instability index80.81
Isoelectric point6.66
Molecular weight80838.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06171
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     376.08|      54|      54|     277|     330|       1
---------------------------------------------------------------------------
  103-  160 (81.49/18.56)	GTQFRRADmrPMQQpmQQQQ........QQQQQQQQQQVPGQIY..SGMRAPPNAE..MQPRLLRPMHQP
  164-  212 (69.88/14.85)	MHHMH.......QQ..QAQM........GQMGMTQSAGIAAAAQ..QQPQNVVMLL..TSGNPPRQAASA
  215-  268 (56.48/10.56)	AVQLRQPN..DIQQ..LEFEcclsdwlvSPILQQLPPAIRQQI.........LQLP..PEEQ.AEQLKKF
  277-  330 (103.14/25.48)	QQQLHQQQ..QIQQ..QQQQ........QQQQQQQQQQIQQQIQ..HQQQQQQQLQ..VQQQIQHQMHHV
  332-  378 (65.07/13.31)	QNQMHTQA..VIQQ..QQQQ........QQQQQQQQQ..QQHFAsvRQQQQMQMLQpmMQQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      88.95|      16|      18|     438|     453|       2
---------------------------------------------------------------------------
  394-  414 (21.15/ 6.72)	SRPPATPVMI..PqTPapvqQPP
  441-  457 (25.86/ 9.95)	SSPAGAHMMG..P.SP...aYAA
  459-  475 (21.82/ 7.19)	TSPVCHPAAT..P.GP...kTSQ
  643-  657 (20.11/ 6.02)	SVP...PIYIriP.TN....YPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.78|      23|      27|     531|     553|       3
---------------------------------------------------------------------------
  531-  553 (41.25/29.79)	RMV....DILEGRNDTSMDVLL.KCE.ET
  555-  583 (28.53/18.57)	KMIcqksDIIKYVTVFSPDCLKgSCEnET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.37|      16|      55|     423|     438|       4
---------------------------------------------------------------------------
  423-  438 (32.08/19.37)	MSGQAAS.PNVNIG...TPY
  476-  495 (23.29/11.86)	MSPAANSlPPESIGaehSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.49|      10|      16|     602|     612|       5
---------------------------------------------------------------------------
  602-  612 (13.60/12.22)	QREIGSlESKF
  620-  629 (19.89/12.59)	QRPLRS.SCKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06171 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAA
2) HQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQHFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
3) QQQPQNVVMLLTSGNPPRQAASAPSAVQLRQ
78
325
190
188
494
220










Molecular Recognition Features






MoRF SequenceStartStop




NANANA