<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06160

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDVYPQDPKQSEANYNDRFISSNFINDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEILLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQKNSENMKEEEEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHDEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSSAVENVSNTQPAVLMSSNFFSEQFKPIEVSNVDFNYFKDSDESKLDFDRIIDFADKKSMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGINQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFAEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTPSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2125
PositionKinase
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.285
Instability index49.18
Isoelectric point6.50
Molecular weight241163.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06160
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.22|      18|      42|    1734|    1755|       1
---------------------------------------------------------------------------
 1734- 1751 (29.61/13.38)	VAISGGTLVSEFSDQVQS
 1772- 1789 (28.61/15.32)	VTVSSNVALSSVPPMVQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     368.89|      66|      67|    1957|    2022|       2
---------------------------------------------------------------------------
 1796- 1850 (52.78/25.68)	............QPT..LTAHYGYYPQQvamTGGpsgavppygqG........QM.....WSIGNVQSAS..TAVPP..........TQ.YQSR...N
 1856- 1928 (88.15/48.33)	M.TPVQS.SSGKQAI..SAMIRGRRPSG...SGG..........QQMmttahiQA.....APLATGQPYHQQQLHSIGQV..DP.MVAPMHQVQmqmD
 1957- 2022 (130.01/75.13)	HCLPQVN.SAASQPV..MHGNYSNYPGQ...HGG..........GRM......QM.....TPSGRNQYAAQQPAQPPFNC..SPNYNAQFYQAQ...N
 2032- 2090 (72.83/38.52)	DVIGQSNvRYTQQPN..AIG..SSY....................QM......QSqqtlrAPAG...YVAQQ.ANPMYAApnTPQYQAA..QQQ...N
 2092- 2124 (25.13/ 7.97)	..........SMYPVsrMSQYSSNVPGQ...EMN..........ASQ......QQ.....I....NYYPPQ...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     352.67|      71|      86|     586|     656|       3
---------------------------------------------------------------------------
  528-  581 (79.31/37.32)	.LFERHLQE..VKHDEF....QLSKK...MP...QVRHPFQ....KSLFNYLH.....................NQAPNLgEMCS...SSEI..KPF
  586-  656 (122.23/61.33)	LLFSRLIESDIFSHDQYVS..TLVSSGDLIPNGANIFYPLQNQCSSSAVENVS.....................NTQPAV.LMSSNFFSEQF..KPI
  674-  745 (54.53/23.45)	LDFDRIID...FADKKSMSsdT...................DSCSSKRVPKLSkhyfnvlhfpvpqddqyrhecNQRQLL.LFGSN..SDQYsrKHI
  783-  844 (96.61/47.00)	CSLSRKIQNLVF.YDQF.A..VMDCCCDAGINQFNSFISGQSNCLPT.LENFD.....................FLLGLL.EESSNFIS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.88|      30|      30|     936|     965|       4
---------------------------------------------------------------------------
  901-  932 (39.31/24.98)	.CNIWRSLL..LYVKSKTVVnsfsaERCVWVYLHD
  936-  965 (58.82/41.65)	CCSYIRSLHADLYLNSRDCI.....QRCLCVETKP
  967-  990 (36.75/22.78)	CCNDLRTLLADV...SQDIM.....LDVLFQE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     180.47|      40|      48|    1246|    1287|       5
---------------------------------------------------------------------------
 1200- 1244 (26.42/15.16)	.....LKSKENFDTKRsaakqfveedtntAGNSDIGSTAIQ.LLELICRQE..
 1246- 1285 (67.85/60.71)	TKRKFLHSTDLFDPKR.............LLNPLVNQTQAQRLLRMITRSDSE
 1296- 1333 (54.64/39.47)	TKKELI..SKVLDSLT.............IMNLWVSQMDLQLLLKQVANSQSE
 1335- 1362 (31.56/20.31)	.....LHLVDTI.AKS.............CME..VFQPQA..TLAFAEPSD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     138.97|      27|      27|    1405|    1431|       6
---------------------------------------------------------------------------
 1364- 1381 (18.12/ 6.01)	............KDENAYLNASSFDEI.APY
 1382- 1403 (24.75/11.06)	WLVAPL...ISRLPS..FVQGRVLKAA....
 1405- 1431 (47.84/28.66)	SILENC...QARRDRNLFVQSSSLLAH.QPF
 1433- 1460 (26.50/12.39)	SLVLIClrgQDDQREGLL...SSLLKQiQEF
 1469- 1485 (21.76/ 8.79)	YIL..C.......DRD..IVSEMLDAL.Q..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.82|      56|     191|     845|     900|       7
---------------------------------------------------------------------------
  845-  900 (100.27/67.21)	LVEFVEAIICLLPKLEAQ..IVERNFQCANSLTLQYAVC..MVGY.MRKHHCY......FIQLESVM
 1034- 1100 (80.54/52.29)	LVLFCADVTALCPNLNADwlAVFKILCCPFNSSQDQSSCdsLLNIdVSDHQCYqpltvlVITLISRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.97|      40|      67|    1533|    1587|       8
---------------------------------------------------------------------------
 1533- 1579 (61.63/63.77)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRI..............YNnvikklKKEIG
 1600- 1654 (59.34/29.62)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQIigkeklnpweiiegYN......RENIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     361.50|     112|     190|     155|     276|       9
---------------------------------------------------------------------------
  155-  276 (174.86/140.29)	PFlnkKDEILYTLAefNVpmVRVVwFLKMTNAHIAQQQEC...GKMKKKHMSDPFADWTH...LVMKYLRDLCSKLGEFFSLNLEVPMNSefECHYRHWQYTTKLTRHLFEEGLLDKEILLNGLLDIF
  352-  469 (186.64/117.47)	PF...HRTVLFGLS..NV..IHAV.LIDCPTALIWNEMECedtGENGKAYLCGSPLDLLYcspVDLPLFMDPSTEFKELERLTEMVTERS..RAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.43|      50|      76|      26|      76|      10
---------------------------------------------------------------------------
   26-   76 (81.85/52.17)	QDPKQSEANYNDRFISSNFINdELTAEKVRQGFIYKPPLLNEYESLRSQRF
  105-  154 (89.58/53.07)	QDSYKKKSGFKEPSIWHFFIA.PLAAKPKGQDTWFKDLSGNKPLSALGKRF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06160 with Med12 domain of Kingdom Metazoa
Unable to open file!