<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06154

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYTMVSLLLSIAHIANGCLKDALCSCDKGLLLGCPISGNILARLASLLHCKMIDTYPLEDVLINDKFDQALVSMNDVCEHFEHCVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTISPLHTDPRDNLFAQVFGKKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMNSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSSTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQCDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVDDEGDVWEWKKKTTRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTILQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQQQQQ
Length1759
PositionHead
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.461
Instability index47.81
Isoelectric point5.44
Molecular weight199250.58
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06154
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     726.17|     215|     223|     973|    1195|       1
---------------------------------------------------------------------------
  913- 1095 (229.71/170.22)	..............................................LLSKDESVKRLLEALHSK.....GVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCD.........dleshlqQSHDGLsslrkDAVIESLQDEVASYEAELKRLRSG...GAIHERE....FTDKMVTDKEYQEL.KLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNasKDQQATLLQSDIDALRGKL
 1096- 1285 (279.57/194.98)	ESKNEmIDQKAQQITELQADKNRLLSELNLLNEQHRISEVG.....LSTKDRKIDLLEETIRER.....DCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERD...LWRKRF......nEEHECL.................................AI.ERK.....RDGEAHEKENKDL.RIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELN..KTNGVDLLKAEIERLNQAV
 1287- 1482 (216.90/144.99)	ESRSE.VDRLLKIIHNSEKEKNEGRESGNDSKRFHSSTENAdyqsvLMHKDRRIEELEEALKESvsitaEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQCDelsIQLKQL..rqekvQS.........DATIKTMQEERKRYVDEVMQLKGEvllAAIEEKDahiaFLENFHGRKSSEEIdNVKKQK..EELLQ..........RLK..EENARRVKLH.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     484.49|     161|     278|     385|     578|       2
---------------------------------------------------------------------------
  385-  578 (247.76/244.60)	HFEHCVPRVECPSLeTFQRDF...LIPQNPVVIEGALESwqameKWNIAYLMSKCAYRTvPiEIGSKYTND.........EWSQKLltvtdfvheyfNP...DAREKAYLAQHQLFEQIteLKDDIAVPDYCCLQCAP..EDVDI.....NAWFGPANTI.SPlhtdprdnlfaQVFGKKYLRlCHPTATKNLY..PITDGLMSNTSQ.IDMEKIDYE.KF
  669-  856 (236.73/159.56)	HHSSCDVHSLCDGV.TFERCFdsqLPPADPQIHAGGFKS.....GFPFSARSSSNSYRQ.P.TLSSHLSHGnlgylqsdcDWSADL...........DPlvkNGRGSNEAPGCGSVSKI..VNGRMTTTNCCPADCDAlrEDLRVameklNATMGSIKSFwSP...........ELKRERALR.KEETAKMNMLqeQLKLSLVNNQKQsVLIEQLQNElRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.46|      27|     223|     113|     139|       3
---------------------------------------------------------------------------
  113-  139 (49.04/32.71)	LGCP...DVLVCSAGVLIPKLLEDHS..DVEI
  337-  368 (40.41/25.59)	LGCPisgNILARLASLLHCKMIDTYPleDVLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      16|      19|    1559|    1577|       4
---------------------------------------------------------------------------
 1559- 1577 (19.66/20.34)	AKQAGFFSlTSEtfFSTTT
 1580- 1595 (30.33/17.13)	AKPVHLFQ.SSE..FPETT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.80|      53|     435|     149|     203|       7
---------------------------------------------------------------------------
  149-  203 (91.64/71.99)	FYPYILKRGQGHIVA.VSSYGGHFGNSYSCCYSASKFAvRGLMESlEWEIYDHGFG
  586-  639 (87.16/59.39)	FYETIVKPGDLLFIPkATGIACDVMNSAGSAAVQSSLA.SGLLPS.PSNLYYQSLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06154 with Med20 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKIIHNSEKEKNEGRESGNDSKRFHSSTENADYQSVLMH
2) SVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQQQQQ
1296
1721
1334
1759










Molecular Recognition Features






MoRF SequenceStartStop




1) PQPQQQQQQQPQQQQQQQQQQQQQ
1736
1759