<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06154

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYTMVSLLLSIAHIANGCLKDALCSCDKGLLLGCPISGNILARLASLLHCKMIDTYPLEDVLINDKFDQALVSMNDVCEHFEHCVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTISPLHTDPRDNLFAQVFGKKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMNSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSSTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQCDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVDDEGDVWEWKKKTTRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTILQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQQQQQ
Length1759
PositionHead
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.461
Instability index47.81
Isoelectric point5.44
Molecular weight199250.58
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06154
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     726.17|     215|     223|     973|    1195|       1
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  913- 1095 (229.71/170.22)	..............................................LLSKDESVKRLLEALHSK.....GVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCD.........dleshlqQSHDGLsslrkDAVIESLQDEVASYEAELKRLRSG...GAIHERE....FTDKMVTDKEYQEL.KLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNasKDQQATLLQSDIDALRGKL
 1096- 1285 (279.57/194.98)	ESKNEmIDQKAQQITELQADKNRLLSELNLLNEQHRISEVG.....LSTKDRKIDLLEETIRER.....DCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERD...LWRKRF......nEEHECL.................................AI.ERK.....RDGEAHEKENKDL.RIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELN..KTNGVDLLKAEIERLNQAV
 1287- 1482 (216.90/144.99)	ESRSE.VDRLLKIIHNSEKEKNEGRESGNDSKRFHSSTENAdyqsvLMHKDRRIEELEEALKESvsitaEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQCDelsIQLKQL..rqekvQS.........DATIKTMQEERKRYVDEVMQLKGEvllAAIEEKDahiaFLENFHGRKSSEEIdNVKKQK..EELLQ..........RLK..EENARRVKLH.............................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     484.49|     161|     278|     385|     578|       2
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  385-  578 (247.76/244.60)	HFEHCVPRVECPSLeTFQRDF...LIPQNPVVIEGALESwqameKWNIAYLMSKCAYRTvPiEIGSKYTND.........EWSQKLltvtdfvheyfNP...DAREKAYLAQHQLFEQIteLKDDIAVPDYCCLQCAP..EDVDI.....NAWFGPANTI.SPlhtdprdnlfaQVFGKKYLRlCHPTATKNLY..PITDGLMSNTSQ.IDMEKIDYE.KF
  669-  856 (236.73/159.56)	HHSSCDVHSLCDGV.TFERCFdsqLPPADPQIHAGGFKS.....GFPFSARSSSNSYRQ.P.TLSSHLSHGnlgylqsdcDWSADL...........DPlvkNGRGSNEAPGCGSVSKI..VNGRMTTTNCCPADCDAlrEDLRVameklNATMGSIKSFwSP...........ELKRERALR.KEETAKMNMLqeQLKLSLVNNQKQsVLIEQLQNElRF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.46|      27|     223|     113|     139|       3
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  113-  139 (49.04/32.71)	LGCP...DVLVCSAGVLIPKLLEDHS..DVEI
  337-  368 (40.41/25.59)	LGCPisgNILARLASLLHCKMIDTYPleDVLI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      16|      19|    1559|    1577|       4
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 1559- 1577 (19.66/20.34)	AKQAGFFSlTSEtfFSTTT
 1580- 1595 (30.33/17.13)	AKPVHLFQ.SSE..FPETT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.80|      53|     435|     149|     203|       7
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  149-  203 (91.64/71.99)	FYPYILKRGQGHIVA.VSSYGGHFGNSYSCCYSASKFAvRGLMESlEWEIYDHGFG
  586-  639 (87.16/59.39)	FYETIVKPGDLLFIPkATGIACDVMNSAGSAAVQSSLA.SGLLPS.PSNLYYQSLG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06154 with Med20 domain of Kingdom Metazoa
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