<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06152

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYTMVSLLLSIAHIANGCLKDALCSCDKGLLLGCPISGNILARLASLLHCKMIDTYPLEDVLINDKFDQALVSMNDVCEHFEHCVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTISPLHTDPRDNLFAQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMNSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSSTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQCDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRDDEGDVWEWKKKTTRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTILQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQQQQQ
Length1591
PositionHead
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index48.15
Isoelectric point5.38
Molecular weight179876.98
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06152
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.78|      19|      19|     859|     877|       1
---------------------------------------------------------------------------
  859-  877 (33.94/20.41)	RDWLISSD.AVKELQYQLES
  879-  898 (26.84/14.65)	RQLLLSKDeSVKRLLEALHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     343.00|      87|     415|     767|     857|       2
---------------------------------------------------------------------------
  769-  857 (143.08/80.98)	TMGSIKSFWSPELKRERALRKEE........TAKMNML.QEQLKLSL..VNNQKQSVLIE.QLQNELRF...QCN..SGRSRRFPDDGPLigHEDY......RTVCQERDMY
  907-  985 (86.95/41.95)	.....QSCAEMELAQNRIVELEE...kcsrlQAHCDDL.ESHLQQSHdgLSSLRKDAVIE.SLQDEV.....ASY..EAELKRLRSGGAI..HERE......FT........
  987- 1041 (48.02/17.22)	KMVTDKEYQELKLKID.ALRGKL........ESKNEMIdQKAQQITE..LQADKNRLLSElNLLNE..............................................
 1194- 1275 (64.96/29.52)	................RIEELEEalkesvsiTAEREMA.VAQQK.....LNSQRAEQRIA.ALKDELKTlqeQCDelSIQLKQLR.......QEKVqsdatiKTMQEERKRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     389.70|     128|     223|     113|     287|       3
---------------------------------------------------------------------------
  113-  275 (185.88/230.27)	LGCP...DVLVCSAGVLIPKLLEDHS..DVEIYRTMNtiRAfypyilkrgqghIVAVSSYGGHFGNsysC................CYSASKFAVRGLMESleWEIYDHgfggeiktttiypfFTRTDLLSSC...NVTSDVIPVLTPEETSQGILKAILYEQtEAFIPfYGSLICYFFKGRTFKAI
  337-  488 (203.82/157.25)	LGCPisgNILARLASLLHCKMIDTYPleDVLINDKFD..QA............LVSMNDVCEHFEH...CvprvecpsletfqrdfLIPQNPVVIEGALES..WQAMEK..............WNIAYLMSKCayrTVPIEIGSKYTNDEWSQKLLTVTDFVH.EYFNP.DAREKAYLAQHQLFEQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.91|      33|     167|     513|     552|       4
---------------------------------------------------------------------------
  513-  545 (61.34/36.25)	NAWFGPANTISPLHTDP.RDNL.FAQIDME.KIDYE
  686-  716 (39.86/18.75)	NSYRQP..TLSS.HLS..HGNLgYLQSDCDwSADLD
  739-  767 (38.71/19.25)	NGRMTTTNCC.PADCDAlREDL...RVAME.KLN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      16|      19|    1391|    1409|       5
---------------------------------------------------------------------------
 1391- 1409 (19.66/20.58)	AKQAGFFSlTSEtfFSTTT
 1412- 1427 (30.33/17.30)	AKPVHLFQ.SSE..FPETT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.69|      39|     166|    1141|    1179|       6
---------------------------------------------------------------------------
 1141- 1179 (63.05/42.78)	VDESRSEVDRLLKIIHNSEK.....EKNEGRESGNDSKRFHSST
 1283- 1311 (18.01/ 6.48)	....KGEV..LLAAIEEKDAhiaflENFHGRKSSE.........
 1313- 1347 (56.63/37.61)	IDNVKKQKEELLQRL....K.....EENARRDDEGDVWEWKKKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.23|      17|     282|    1078|    1104|       7
---------------------------------------------------------------------------
 1074- 1090 (26.24/23.59)	IRTRLNSSPGVIQEKKL
 1101- 1117 (26.00/ 6.08)	INDMVRQTEALTKENSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06152 with Med20 domain of Kingdom Metazoa
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