<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06151

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYTMVSLLLSIAHIANGCLKDALCSCDKGLLLGCPISGNILARLASLLHCKMIDTYPLEDVLINDKFDQALVSMNDVCEHFEHCVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTISPLHTDPRDNLFAQVFGKKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMNSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSSTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTLQEQCDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKDDEGDVWEWKKKTTRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTILQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQQQQQ
Length1752
PositionHead
OrganismTrichinella patagoniensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.470
Instability index48.15
Isoelectric point5.45
Molecular weight198566.79
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06151
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     828.67|     220|     221|     893|    1113|       1
---------------------------------------------------------------------------
  736-  886 (79.39/45.78)	...........................................................................LQSDCDwsaDLDPLVKNgrgSNEapGCGSvskivngrmtttnccpadcdaLREDlrVAMEKLNATMGSI..KSfwspELKRER...........ALRKEE.....TAKMNMLQEQLKL.SLvnnQKQSVLIEQLQNELRFQCNSGR.SRRFPDDGPLIGH.EDYRTVCQERD....................................
  893- 1113 (342.34/232.37)	LISSDAVKELQYQLESQ..RQLLLSKDESVKRLLEAL.HSKGVPA....SVAQSCAEMELA.QNRIVELEEKCSRLQAHCD...DLESHLQQ...SHD..GLSS.....................LRKD..AVIESLQDEVASY..EA....ELKRLRSG...G.....AIHERE....FTDKMVTDKEYQEL.KL...KADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKL.ESKNEmIDQKAQQITELQ
 1119- 1303 (228.64/149.20)	LLS.....ELNL.LNEQ..HRI.................................SEVGLStKDRKIDLLEETIR.ERDCE..lNLIRTRLN...SSP..GVIQ.....................EKK........LQDEINRLvqER....DLWRKRFN...EeheclAI.ERK.....RDGEAHEKENKDL.RI...AIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELN..KTNGVDLLKAEIERLNQAVdESRSE.VDRLLKIIHNSE
 1310- 1482 (178.30/114.13)	RESGNDSKRFHSSTENAdyQSVLMHKDRRIEELEEALkESVSITAeremAVAQQKLNSQRA.EQRIAALKDELKTLQEQCD...ELSIQLKQ...LRQ....EK.....................VQSD..ATIKTMQEERKRY..VD....EVMQLKGEvllA.....AIEEKDahiaFLENFHGRKSSEEIdNV...KKQK..EELLQ..........RLK..EENARRVKLH................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.02|      63|     279|     385|     455|       2
---------------------------------------------------------------------------
  385-  455 (100.06/113.74)	HFEHCVPRVECPSLeTFQRDF...LIPQNPVVIEGALESwqameKWNIAYLMSKCAYRTvPiEIGSKYTNDE.........WS
  669-  743 (107.95/88.98)	HHSSCDVHSLCDGV.TFERCFdsqLPPADPQIHAGGFKS.....GFPFSARSSSNSYRQ.P.TLSSHLSHGNlgylqsdcdWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.46|      27|     223|     113|     139|       3
---------------------------------------------------------------------------
  113-  139 (49.04/33.47)	LGCP...DVLVCSAGVLIPKLLEDHS..DVEI
  337-  368 (40.41/26.16)	LGCPisgNILARLASLLHCKMIDTYPleDVLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06151 with Med20 domain of Kingdom Metazoa
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