<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06141

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLELFFLCFPSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQPQQQQQQQQQQVAGQIYSGMRAPPNAEMQPRLLRPMHQASVTMHHMHQQQAAQIGQMGITQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAGQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQQQQLHQQQQIQQQQQQQQQQQQQQIQQQIQHQQQQQLQVQQQIQHQIHHVAQNQMHPQAVIQHQQQQQQQQQQQHQQQFASVRQQQQMQMLQAPMMQQPGAVRFADQSTMLYTRPPATPAMMPHTPAPVQQPPSQPAPVTPMSGQAASPNVNMGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPVATSCPKTSQVSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSEIIKVKDRNINQPLLDAISAITKRERQKINLYEYFNFPLYQCSLKNTCPDCLKGICEYEAAQTSNVEDSDQIGIPLNIQREIGNLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYRDSPYLNSIRKSLESFSSDTGAPNTISALLTNWENCVRDASFI
Length737
PositionTail
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.752
Instability index73.74
Isoelectric point7.96
Molecular weight83803.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06141
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.17|      16|      16|     282|     297|       1
---------------------------------------------------------------------------
  121-  135 (32.12/ 9.27)	QQQPQQQQQQQ.QQQV
  263-  278 (31.36/ 8.84)	WQQQQQQQQLHQQQQI
  282-  297 (35.81/11.33)	QQQQQQQQQQQIQQQI
  300-  315 (29.09/ 7.58)	QQQQQLQVQQQIQHQI
  332-  347 (34.79/10.76)	QQQQQQQQQQQHQQQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     195.39|      32|      32|     417|     448|       2
---------------------------------------------------------------------------
   75-  101 (34.45/12.72)	..ASSGAAAM..........SQPQR........HQ.AP...VNqVPY....GNM..Q
  160-  211 (26.56/ 7.88)	HQASVTMHHMhqqqaaqigqMG.ITqsagiAAAAQQQP...QN.VVMlltsGNPprQ
  383-  399 (35.30/13.24)	PPATPA...M..........M.PHT.....P.....AP...VQ.............Q
  400-  425 (48.73/21.47)	PPSQPA................PVT.....PMSGQAAS...PN.VNM....GTP..Y
  426-  459 (50.36/22.47)	PSSSPAGAHM..........MGPSP.....AYAAETSPvchP..VAT....SCP..K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     216.34|      50|      56|     583|     638|       3
---------------------------------------------------------------------------
  535-  574 (57.21/29.50)	...LK..CEETLKMIC..QKSEIIKVKDRN.INQPL..LDAIS..AIT.KRER
  589-  638 (86.89/60.09)	QCSLKNTCPDCLKGICEYEAAQTSNVEDSDQIGIPLNIQREIG..NLE.SKFR
  645-  695 (72.24/36.92)	QRPLRSSC.KFISVLCELLDITLPSVPPI.YIRIPTNYPQSPPkyDLEwSQYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.71|      10|      20|     350|     359|       6
---------------------------------------------------------------------------
  350-  359 (18.92/ 9.10)	VRQQQQMQML
  370-  379 (17.79/ 8.08)	VRFADQSTML
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06141 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQPQQQQQQQQQQVAGQIYSGMRAPPNAEMQPRLLRPMHQASVTMHHMHQQQAAQIGQMGITQSAGIAAA
2) QQQIQHQIHHVAQNQMHPQAVIQHQQQQQQQQQQQHQQQFASVRQQQQMQMLQAPMMQQPGAVRFADQSTMLYTRPPATPAMMPHTPAPVQQPPSQPAPVTPMSGQAASPNVNMGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPVATSCPKTSQVSPAANSLPPESIGAEHSP
3) QQQPQNVVMLLTSGNPPRQAASAPSAGQLRQPNDIQQFLQ
78
308
193
191
481
232










Molecular Recognition Features






MoRF SequenceStartStop




NANANA