<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06138

Description Mediator of RNA polymerase II transcription subunit 22
SequenceMDEGRKNISARKAMLLKEYQLLLQRSVKSIRENFTEIIKMARIGEDGQVSRLTEYEHELFEMQIRAANMTHAAEALIKMVTDLKQFLILNDFAYINESITTSAVHNQIAQREFRDKLIAVKEEMAYCLQEAEQEYYNTALKNSVSVFDLFEIEFLRIKMTLDEFGTELYVDPWQTFVSIKGKLRKRAFRSPNLAEVVKDYEALANRLLDENCTEYSALCRMNMAKCKNQLGNIDQEAVEYRTAGRLYIRAEKEKESVENRLSMECLYMAMHCYNEAIRLHLSQGQKLLAASLLIELGKELACMQHPEDAIQNFEKAVHLLDTHPHAVGHALRWKLCVETSVGFLADARRTSNFYRQIVESWPNSGSRKLHLNELEIITVMLLLALKPINSEMNDFEKRLLQRYSDESNEAFFTNEGSLLPNDSYIISVEIYLQLKSFVLAINNNDPSAADIALTAMHHHNVKLVHSAKTDASVPLRSLFYNESSVSLEVDSDFKVRDVINAYAYRTGHNEKDEEFVLRFHDHSSLNSEDPLHVLGVYNDEELIISVRGEDSRRSRNSWWWLGSVALLISLVGLTAVSVLFALSGDLPDEFGIIIDAGSSHSGLYIYTWNGRKNKTGVIKQYAPSCTTEIGISSFTDSPVDAGNSLLFCLNNASATTS
Length657
PositionHead
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.245
Instability index42.19
Isoelectric point5.49
Molecular weight74760.13
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
hydrolase activity	GO:0016787	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06138
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.77|      15|      17|     234|     248|       1
---------------------------------------------------------------------------
  209-  223 (26.45/16.67)	DENCTEYS.ALCRMNM
  234-  248 (25.22/15.57)	DQEAVEYR.TAGRLYI
  253-  268 (21.10/11.87)	EKESVENRlSMECLYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.17|      57|     502|      33|      91|       2
---------------------------------------------------------------------------
   33-   91 (87.06/65.38)	NFTEIIKMARiGEDGQVSRLTEYEHELFEMQIRAANMThAAEALIKMVTDL.KQFLILND
  538-  595 (92.12/59.71)	NDEELIISVR.GEDSRRSRNSWWWLGSVALLISLVGLT.AVSVLFALSGDLpDEFGIIID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06138 with Med22 domain of Kingdom Metazoa
Unable to open file!