<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06128

Description Cyclin-dependent kinase 8 (Fragment)
SequenceLMLLQVDMVDHDFKMRLNAQRQRVEDMFDFEGRKVGRGTYGHVYKACPRNDDGEYKNQYAIKLIEGAGISMSACREIALLRELKHPNVISLQRVFLSHSDRKVWLLFDYAEHDLWHIIKFHRAAKASKRTVMVPKGMVKSLLFQILDGIHYLHSNWVLHRDLKPANILLMGDGPERGRVKIADMGFARLFNNPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAVGCIFAELLTSEPIFHCRQEDIKTSNPYHQDQLDRIFNVMGFPNEKDWEDIRKMPEYQKLTTDFKRNAYLSSNLQKYMEKHKVKSECRAFLLLQKLLTMDPTKRISAQEAMDDPYFKEEPTPTSDVFLGCPIPYPKREFLTDEETEEKSEMTKQSTQATLPPVATLSTVGSLDQPGPMKKMRMNAEFGSGAPNPNVIHPAVTSTMQSTMVSAQMHNINPATVTMSSSLNYGQVFPHRF
Length467
PositionKinase
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.419
Instability index45.05
Isoelectric point8.54
Molecular weight53682.36
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06128
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.02|      31|      35|     145|     175|       1
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  145-  175 (57.71/34.81)	ILD.GIHYLHSNWVLH.RDLKPANILLMGDGPE
  181-  213 (48.31/28.12)	IADmGFARLFNNPLKPlADLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.94|      49|     245|      29|      83|       2
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   29-   83 (72.09/70.44)	DFEG.RKVGRgtYGHVYKACPRNddgEYKNQYAIKLIEGAGISmSACREIALLREL
  276-  325 (82.85/57.85)	DWEDiRKMPE..YQKLTTDFKRN...AYLSSNLQKYMEKHKVK.SECRAFLLLQKL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06128 with CDK8 domain of Kingdom Metazoa
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