<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06118

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCYGYTWSILECFFKKPKSVNDKVVVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRHETSACVYAYTADVTDPESMRQVANAIVCNPELGCPDVLVCSAGVLIPKLLEDHSDVEISRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFSGEIKTTTIYPFFTRTDLLNSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGYIMNEIVFTEFIPESVETWLSLLDDHVVPGDMFLLLRRTFKALELKDFEVAVEICNFMLNFIWERLNTGHWSEVNISWRLLYSMVSLLLSIAHTANARLKDALCSCDKGLLLGCPISGNALARLASLLHCKMINTYPLEDMLIDDKFDQALASMNDVCGQFEHSVPRVACPSLETFQRDFLIPQNPVVIEGALESWQAMKKWNIAYLMSKCAYRTVPVEIGSKYTNDEWSQKLLTIADFVHKYFNPNVREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGKKYFRLCHPTTTKNLYPITDGLMSNTSQIDMEDIDYEKFPLVKNVKFYETIVKPGDLLFIPKDTGIACDVMSSAGSAVVQCSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRGGHFTRARHHSSCDVHSLCDGVTFERSFDSQPDCDWSSDLDPLVKGSRSANEASGCGSGSKIVNGRMTTSNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSEAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSNLRKDAVIESLQDEVASYEAELKRLRAGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIARLNQAVDESRSEVDRLLKIIHTSEKEKNEGRESGNDSKRFHSSAENADYQAVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRITACKDQLKTLQEQYDELSLQLKQLRQEKAQSDATIEAMQEERKRYVDERMQLKGEALLAAIGEKDAHIALLENCRGRKSSEEIDTLQKQKEELLQRLKEENARRVKLHSDPTLNFTDHFSKVSGVDLVRHSLPAMGISWVYLYSDPEKSDRQDLLLDSLQTALNNMDAKQTGFFTITSETFFSTSTTNTKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEVEYRPCIVMQLCGDLMKEFCTALLGTAASGPPTFAGLTKPNQRYVPIDTIFQYHCYFMHFRKMSVQTTVSNDQQSQPQQQQQQQQQQQQQPQQQQQQQQ
Length1746
PositionHead
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index45.90
Isoelectric point5.53
Molecular weight198198.82
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06118
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     670.61|     139|     140|     803|     942|       1
---------------------------------------------------------------------------
  804-  940 (216.17/124.23)	..SFWSPELKRERAL..............RKEET.AKMNMLQEQ.....LKLSL..VNNQK.QS.VLIEQLQNEL........R.FQCNSG.RSR.RFPDDGPL..IG....HEDY................RTVCQERDMYR.........................RDWLISSEAVKELQYQLES..QRQLLL.SKDESVKRL...LEAL.HSK.............GVPA....SVAQSCAE
  941- 1109 (115.71/62.49)	ME.............laqnriveleekcsRLQ...AHCDDLESH.....LQQSHdgLSNLR.KD.AVIESLQDEVasyeaelkR.LRAGGAiHER.EFTD..KM..VT....DKEYqelklkadklelelgqKTV.EIQALYT.........................R.LSTAEESASDFKKHLEL..MKESNA.SKDQQATLLqsdIDAL.RGK.......leskneMIDQ....K.AQQITE
 1110- 1246 (98.38/52.00)	LQ......ADKNRLL....................SELNLLNEQ.....HRISE..VGLST.KD.RKIDLLEETI........ReRDCELN.LIRtRLNSSPGV..IQekklQDEI................NRLVQERDLWRkrfneeheclaierkrdgeahekenKDLRI...AIASLQKEI.S..DRQVFIeSQNEKINDM........................................
 1247- 1360 (100.97/53.33)	..............V..............RQTEAlTKENSLYKE.....L........NKT.NG.V..DLLKAEI.......aR.LNQAVD.ESR.SEVDRLLK..II....H....................TSEKEKNEGR.........................E....SGNDSKRFHSSAENadYQAVLM.HKDRRIEEL...EEALkESV.............SITAeremAVAQ....
 1361- 1506 (139.38/76.57)	..QKLNSQRAEQRIT..............ACKD...QLKTLQEQydelsLQLKQ..LRQEKaQSdATIEAMQEE.........R.KRYVDE.R.M.QLKGEALLaaIG....EKDA................HIALLENCRGR.........................K....SSEEIDTLQKQKEE..LLQRL...KEENARRV.....KL.HSDptlnftdhfskvsGVDL.....VRHSLPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.24|      90|     267|      99|     197|       2
---------------------------------------------------------------------------
   99-  197 (141.84/122.10)	SMRQVANA....IVCNPE....LGCP...DVLVCSAGVLIPK..........LLEDHSDVEISrTMNTIRAFYPYILKRgqghiVAVSSYgGHFGNSYscCYSASKFAVRGLMESLE....WEI
  359-  473 (134.39/88.70)	SIAHTANArlkdALCSCDkgllLGCPisgNALARLASLLHCKmintypledmLIDDKFDQALA.SMNDVCGQFEHSVPR.....VACPSL.ETFQRDF..LIPQNPVVIEGALESWQamkkWNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.96|      30|      63|     548|     578|       3
---------------------------------------------------------------------------
  548-  578 (52.13/38.75)	QCAPEDVDINAwFGPANTVSPLHT..DPRDNLF
  611-  642 (49.84/30.74)	QIDMEDIDYEK.FPLVKNVKFYETivKPGDLLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.77|      34|      63|     651|     688|       4
---------------------------------------------------------------------------
  651-  688 (54.35/45.10)	CDVMSSAGSAVVQCSLASgllpSPSNLYYQSLGHITGG
  717-  750 (64.42/42.42)	CDVHSLCDGVTFERSFDS....QPDCDWSSDLDPLVKG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06118 with Med20 domain of Kingdom Metazoa
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