<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06117

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATFSFGEPSDDKDENAYLNALSFDEIAPCWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVIVQLLLYGIVTEEKNQTLFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVYQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLISEFSDQVQSPRTTKARVRKSTRGRKSSSRVAVSSNVALSSVPMVQTRQLSIGQPTITAHYGYFPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGSQQMMSAAHIQAAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQETMMEQQMRTPGPRSMATQQHCMPQVNSAASQPGTIVMHGNYSNYPGQQHAAGRMQMTSGRSQYAAQPAQPPFNCSPNYNAQFYQAQNAGQMRMPQTDVIGQSNVRYTQQPNAIGSNYQMQSQQTLRPPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length890
PositionKinase
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.439
Instability index54.78
Isoelectric point8.79
Molecular weight99804.74
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06117
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     291.26|      35|      35|     776|     810|       1
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  608-  665 (29.74/10.63)	TQYQsRNFTgaqmaPMQSssgkqaisamiRG........RRPS..GSGSQQMMSA........AhiqaaplaAGQP
  666-  707 (32.36/12.26)	..YH.QQ.......QLHS...........IGQvdpM...VAPM..HQVQMQMDARqqlmqetmM........EQQM
  710-  732 (38.64/16.19)	PGPR.SMAT.....Q................Q...H...CMPQ..V......N.S........A........ASQP
  739-  771 (45.91/20.74)	GNYS.N..Y.....PGQQ.........haAGR...M...QM....TSGRSQYAAQ........P........AQPP
  776-  810 (64.06/32.09)	PNYN.AQFY.....QAQN...........AGQ...M...RMPQ..TDVIGQSNVR........Y........TQQP
  815-  843 (46.72/21.25)	SN......Y.....QMQS...........QQT...L...RPPA..GYVAQQANPM........Y........A.AP
  846-  882 (33.83/13.19)	PQYQ.AA.......QQQN...........VSM...YpvsRMSQysSNVPGQEMNA........S........QQQ.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.58|      32|      35|     490|     523|       2
---------------------------------------------------------------------------
  490-  522 (47.91/29.58)	TERLKSNGSVAISGGTLISEFsDQVQS.......PRTTKA
  528-  566 (43.67/22.49)	TRGRKSSSRVAVSSNVALSSV.PMVQTrqlsigqPTITAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.98|      12|      35|      44|      55|       3
---------------------------------------------------------------------------
   44-   55 (18.79/10.91)	ITRSDSEILLKK
   80-   91 (18.19/10.33)	VSQMDLQLLLKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.96|      19|     195|     118|     136|       5
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  118-  136 (35.21/27.88)	ATFSF.GEPSDDKD.ENAYLN
  314-  334 (26.74/19.22)	AGFSFsGQERTNEDcKRIYNN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.27|      21|     148|     268|     294|      10
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  268-  294 (32.53/37.22)	NLEN....WSlvivqlLLYGIVTEEKNQTLF
  414-  438 (37.74/27.26)	NRENiglkWS......WFQGIRLDYQPETLF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06117 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSDQVQSPRTTKARVRKSTRGRKSSSRVAVSSNVA
2) GQMRMPQTDVIGQSNVRYTQQPNAIGSNYQMQSQQTLRPPAGYVAQQANPMYAAPNTPQYQAAQQQN
3) IGNVQSASTAVPPTQYQSRNFTGAQMAPMQSSSGKQAISAMIRGRRPSGSGSQQMMSAAHIQAAPLAAGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQETMMEQQMRTPGPRSMATQQHCMPQVNSAASQPGTIVMHGNYSNYPGQQHAAGRMQMTSGRSQYAAQPAQPP
510
789
595
544
855
771










Molecular Recognition Features






MoRF SequenceStartStop




1) INYYPPQY
2) ISAMI
883
632
890
636