<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06116

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLDDYFIKLTQSYNAIVSKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSMEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMIVPVLLQRNFVSLKFIDGFLMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGLLDYLNCPFHRTVLFGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQLSGLSTIIQHFLSILDCLDKFKFEYVNETNNTDALYKTIFQSEKKETRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFMNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQPAILMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSLRRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQSANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRSLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKTMCGLSDDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSNQDQTSCDSLLNIDVSDHQCYQPLTVLTITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATFSFGEPSDDKDENAYLNALSFDEIAPCWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVIVQLLLYGIVTEEKNQTLFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNKEIGDRQMPSLRCVYQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLISEFSDQVQSPRTTKARVRKSTRGRKSSSRVAVSSNVALSSVPVRRIIVVLIHISWVLNY
Length1759
PositionKinase
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.150
Instability index44.77
Isoelectric point6.34
Molecular weight201028.71
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06116
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.51|      53|     330|     153|     208|       1
---------------------------------------------------------------------------
   62-  129 (70.52/37.85)	KLTqsyNAIVSKKAEINALqdsykKKSGFKEP.SIW.HLAAKpkgqdtWFKDL.SGNKPLSALGKRFPfLN
  153-  208 (85.00/60.07)	KMT...NAHIAQQQECGKM.....KKKHMSDPfADWtHLVMK......YLRDLcSKLGEFFSLSMEVP.MN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.42|      51|     330|     929|    1082|       2
---------------------------------------------------------------------------
  797-  856 (76.18/11.23)	LLGLLEESSNFISL.VEFMEAVICLLPKLEAQIVErnfqsANSLTLQYAVCMVgymrKHHC
  936-  987 (81.24/203.92)	LRSLLADVSQEIMLdVLFQESDLVIEPNLIQRLVE.....NANLCYAFAIVAV....KTMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.94|      26|      59|    1226|    1251|       3
---------------------------------------------------------------------------
 1226- 1251 (43.47/30.66)	LLNPLVNQTQAQRLLRMITRSDSEIL
 1274- 1299 (44.47/31.56)	IMNLWVSQMDLQLLLKQVANSQSESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.77|      19|     330|    1322|    1345|       4
---------------------------------------------------------------------------
 1322- 1345 (26.59/29.27)	GEPSDDkdenAYLNALSFDEIaPC
 1653- 1671 (38.17/23.49)	GEPRSD....PFLETLQVHYV.PC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.06|      34|      72|     235|     268|       5
---------------------------------------------------------------------------
  235-  268 (56.32/39.41)	DKEMLLNGLLDIFAEKIYASS.FGILKMIVPVLLQ
  309-  343 (55.74/38.91)	DSENMKEGLLDYLNCPFHRTVlFGLSNVVHSVLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.44|      34|     330|     673|     711|       6
---------------------------------------------------------------------------
  673-  711 (60.60/41.52)	FNVLHF........PVPQDDQ...YRHECNQrqlllFGSNSDQYSRKHIL
  997- 1041 (53.83/27.86)	FNLVLFcadvtalcPNLNADWlavFKILCCP.....FNSNQDQTSCDSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.20|      19|     330|     562|     607|       9
---------------------------------------------------------------------------
  514-  532 (36.34/37.41)	QVRYPFQK......SLFNYLHNQAP
  583-  607 (27.87/17.04)	NVFYPLQNqcsssaSAVENVSNTQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.14|      23|     700|     460|     482|      10
---------------------------------------------------------------------------
  460-  482 (44.17/34.00)	FQSEKKET..RVDMDSIAVQFL...C..HW
 1180- 1209 (27.97/18.35)	FVEEDTNTagNSDIGSTAIQLLeliCrqEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.45|      33|     664|     735|     771|      13
---------------------------------------------------------------------------
  735-  771 (52.38/49.49)	LIRVRKIIDSES..LCSLSRKIQNLVFY...DQFAVmdccCD
 1400- 1437 (50.07/33.75)	LICLRGQDDQREglLSSLLKQIQEFVMRvkeDPYIL....CD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      11|      51|    1165|    1175|      14
---------------------------------------------------------------------------
 1165- 1175 (19.76/11.91)	LKSKENFDTKR
 1215- 1225 (21.26/13.41)	LHSTDLFDPKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06116 with Med12 domain of Kingdom Metazoa
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