<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06115

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGYIYKPPLLNEYESLRSQRFDENLDDYFIKLTQSYNAIVSKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLSMEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMIVPVLLQRNFVSLKFIDGFLMSVLLSRRLVYLACKVLSAMKIDNLQNDSENMKEGLLDYLNCPFHRTVLFGLSNVVHSVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFVDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQLSGLSTIIQHFLSILDCLDKFKFEYVNETNNTDALYKTIFQSEKKETRVDMDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRYPFQKSLFNYLHNQAPNLGEMCSSSEIKPFMNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANVFYPLQNQCSSSASAVENVSNTQPAILMSNNFFSEHFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAISSDADSCSLRRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFINGQSNCLPTLENFDFLLGLLEESSNFISLVEFMEAVICLLPKLEAQIVERNFQSANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSSCNDLRSLLADVSQEIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKTMCGLSDDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSNQDQTSCDSLLNIDVSDHQCYQPLTVLTITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGPEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATFSFGEPSDDKDENAYLNALSFDEIAPCWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFAQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVIVQLLLYGIVTEEKNQTLFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQMPSLRCVYQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYVPCTNETSDSDKLTTERLKSNGSVAISGGTLISEFSDQVQSPRTTKARVRKSTRGRKSSSRVAVSSNVALSSVPVRRIIVVLIHISWVLNYCLCTRCNEM
Length1774
PositionKinase
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.148
Instability index44.49
Isoelectric point6.48
Molecular weight202792.96
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06115
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.06|      34|      72|     235|     268|       1
---------------------------------------------------------------------------
  235-  268 (56.32/43.34)	DKEMLLNGLLDIFAEKIYASS.FGILKMIVPVLLQ
  309-  343 (55.74/42.80)	DSENMKEGLLDYLNCPFHRTVlFGLSNVVHSVLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.97|      40|      48|    1210|    1251|       2
---------------------------------------------------------------------------
 1210- 1251 (62.13/49.56)	TKRKFLhsTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEIL
 1260- 1299 (64.84/44.49)	TKKELI..SKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.39|      36|      48|     782|     819|       3
---------------------------------------------------------------------------
  747-  768 (21.96/ 8.32)	................LCSLS.RKIQNLVFYDQF..AVMdC
  782-  819 (54.32/43.58)	NGQS.NCLpTLENFDFLLGLL.EESSNFISLVEFmEAVI.C
  832-  866 (54.11/33.03)	NFQSaNSL.TLQYAVCMVGYMrKHHCYFIQL....ESVM.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.83|      28|     472|     190|     217|       4
---------------------------------------------------------------------------
  190-  217 (55.36/36.21)	DLCS.....KLGE.FFS.LSMEVPMNSEF..ECHYRH
  658-  694 (36.46/21.08)	DSCSlrrvpKLSKhYFNvLHFPVPQDDQYrhECNQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.16|      48|      48|     940|     987|       5
---------------------------------------------------------------------------
  940-  987 (80.36/44.57)	LADVSQEIMLDVLFQESDLVIEPNL.IQRLVENANLCYAFAIVAVKTMC
  989- 1037 (82.80/46.14)	LSDDTERLFNLVLFCADVTALCPNLnADWLAVFKILCCPFNSNQDQTSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.72|      32|     330|     153|     189|       6
---------------------------------------------------------------------------
   62-  101 (43.12/23.36)	KLTqsyNAIVSKKAEINALqdsykKKSGFKEP.SIW.HLAAK
  153-  186 (52.61/51.16)	KMT...NAHIAQQQECGKM.....KKKHMSDPfADWtHLVMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.20|      51|     699|     419|     482|       7
---------------------------------------------------------------------------
  427-  482 (82.19/88.26)	IIQHFLSILdCLDKFKFEYVNETNNTDA.lyktIFQSEKKET..RVDMDSIAVQFL...C..HW
 1147- 1209 (66.01/40.07)	ILTLLIAIL.MLDDSKVQELKSKENFDTkrsakQFVEEDTNTagNSDIGSTAIQLLeliCrqEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.83|      43|     966|     345|     393|       8
---------------------------------------------------------------------------
  345-  393 (65.22/54.83)	PTALI.WNEmECEDTGENgkAYLCGSPLD.LLYCSPVdLPLFVD.PSteFVK
 1315- 1360 (68.62/37.60)	PQATFsFGE.PSDDKDEN..AYLNALSFDeIAPCWLV.APLISRlPS..FVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06115 with Med12 domain of Kingdom Metazoa
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