<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06111

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKTIIFTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDLFVRDVTQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNATNSMPFPNGNVSEVKLRPLKLEFLDSVSVHGKNAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHHEIFQAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPCYSWPQSTLSVFPQQQQQQQQQQQQQQQQQQQQQQQPQPQQSSVVGSSQQQQQQQQQQQQQQNHLLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYATLVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWNYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLPLLRVNNQARHFPCRRSWYSSGVAVFQIQWKVEFHSVVLLYFFETVFLRAQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAAVDMVIVGAFSEICNCVLKWCVFFGILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLEFA
Length1541
PositionTail
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy-0.012
Instability index47.17
Isoelectric point6.68
Molecular weight178202.97
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06111
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.87|      29|      33|     725|     756|       1
---------------------------------------------------------------------------
  725-  753 (57.46/36.96)	PQSTLSVFPQQQQQQQQQQQQQQQQQ...QQQ
  759-  790 (51.42/25.33)	PQQSSVVGSSQQQQQQQQQQQQQQNHlllKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      85|     273|     287|       2
---------------------------------------------------------------------------
  273-  287 (28.85/17.43)	RLLTHVFMHYTYRDA
  355-  369 (28.86/17.44)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.13|      41|      84|     112|     154|       3
---------------------------------------------------------------------------
  112-  154 (70.99/52.71)	ELNINSC..GW..NDTFAFFMEniSLLDYKGVRDTLKRLLDIPIPVH
  193-  237 (68.14/44.45)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.14|      25|      84|    1423|    1447|       4
---------------------------------------------------------------------------
 1423- 1447 (44.99/21.46)	QHF.WLAVTKLGDP....VMTFSLYFPALF
 1462- 1481 (28.43/11.10)	......AFSEICNC....VLKWCVFFGILL
 1503- 1532 (36.72/16.29)	KQFqWTCETGPGSPsghaMVSASVWFNLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.40|      25|      85|     440|     475|       6
---------------------------------------------------------------------------
  450-  475 (41.35/54.76)	QRkFLQEALKNKTQFNTDNY..MVAVLC
 1284- 1310 (43.05/24.91)	QR.FYQERTKFTMDITTDLYqmLYNVDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.89|      38|     171|    1062|    1102|      12
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 1062- 1102 (69.59/46.30)	CVPSR.....DDHWLLSAE.FVSCVgsgPVTDRGPWVPDLN......YYATLV
 1230- 1279 (58.30/31.43)	CYPARilalcHAVWLHSASgYLQLL...PQALRSTWIPHVRsegqflYVCHLV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06111 with Med23 domain of Kingdom Metazoa
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