<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06110

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKTIIFTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDLFVRDVTQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSGKNAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSMLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYATLVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLAQFGRQKYRHISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWNYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSEMINPIKFLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAAVDMVAQVVMRWFRLRDFSGLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRQWSNLIAFMIVLLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAVLLANKSMLTNNNNNNSTSKPFSSKFAQALLGVGLNQLCKHLLFCC
Length1130
PositionTail
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy0.154
Instability index43.41
Isoelectric point8.27
Molecular weight130229.42
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06110
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.37|      22|      48|     646|     676|       1
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  660-  704 (20.38/24.52)	FnnFQThALYCICIELMslsvsvvdvgnalitlaqfgRQKYRHIS
  709-  739 (30.99/14.23)	F..YQT.ILTTLCSDHM...........nsmntdvsnKLDFEKRS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.80|      44|      52|     937|     988|       2
---------------------------------------------------------------------------
  937-  958 (19.11/ 7.81)	................................ALFPFFGtAAVDMVAQVVMRWF
  959- 1010 (61.84/46.16)	RLRDFSGLCWLLYVVFLIAVSIsrtyisaHfpDQV.ILG.IVVGICIALVTRSL
 1014- 1043 (42.86/20.90)	RRRQWSNLIAFMIVLLLIALSV.......H..EAHRFLG...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.47|      57|      84|     103|     159|       3
---------------------------------------------------------------------------
  122-  205 (78.43/47.61)	DTFAFFMENISLLDYKDLLNPQMRLLT.HVFMHYTYRDAiavllgtakpeksripyfeeviteiI....LELMFTaeCDHS......QLNPQAWR
  208-  267 (76.20/46.04)	STQIIYLTLQQSICFTRLV....KILH.TKLTHYPYRYA..................rnqlmwcL....FNFLSG..GMQK......YSGKNAWP
  268-  325 (54.84/31.00)	SP.ALVETYCRMLTYADLEILGLKQFTsHIVLTAA..............................rhqcCEMMYI..CCEIlnyrlfNIPS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.71|      18|      40|     499|     516|       4
---------------------------------------------------------------------------
  499-  516 (35.49/19.39)	ELSRASLTPNDCPL....PVY.F
  536-  558 (23.21/10.31)	ESPAACLKFLDSTLsilgPLYrF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.06|      27|     279|     561|     587|       5
---------------------------------------------------------------------------
  561-  587 (46.91/30.81)	YPVSFLY.....STF..RFYEKRLVEAPAIKQKL
  787-  816 (24.68/12.52)	....FLYvchlvAPFlqRFYQERTKFTMDITTDL
  841-  867 (37.46/23.04)	YHVKYMY...vgDSV..RQETDRII..PMLRTSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.42|      10|     302|     751|     760|       6
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  751-  760 (22.20/15.92)	LA..LCH.AVWLH
 1052- 1064 (14.22/ 6.91)	LAakYCHrAEWIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.27|      23|     179|     881|     904|      13
---------------------------------------------------------------------------
  881-  904 (38.42/28.70)	QSGTPFSEMINPIKFLgIQMVVWL
 1065- 1087 (37.84/22.98)	QSTTPLASFFRDVGVL.ISIAVLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06110 with Med23 domain of Kingdom Metazoa
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