<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06110

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFETKVKNLFKEHAKSGIAYFFFRPYLMTSSEECEKKTIIFTANELVEIFTSVPQNLQESAFSIVISHRVLSNSANKIVDLFVRDVTQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSGKNAWPSPALVETYCRMLTYADLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIAPFARLLNSFVAVAADGTRQSIAENEELMRIIILTLARSTVISSMLGPRKVLIHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQLKHAERTWSQVHTELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVEAPAIKQKLALAVHGACVPSRDDHWLLSAEFVSCVGSGPVTDRGPWVPDLNYYATLVRRLMDTFSEPRQQWSRKSDLRFVEFNNFQTHALYCICIELMSLSVSVVDVGNALITLAQFGRQKYRHISYMEPFYQTILTTLCSDHMNSMNTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSASGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVSSWNYEDLICDFFYHVKYMYVGDSVRQETDRIIPMLRTSLQQKLRYISFAQGEQSGTPFSEMINPIKFLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAAVDMVAQVVMRWFRLRDFSGLCWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRQWSNLIAFMIVLLLIALSVHEAHRFLGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISIAVLLANKSMLTNNNNNNSTSKPFSSKFAQALLGVGLNQLCKHLLFCC
Length1130
PositionTail
OrganismTrichinella pseudospiralis (Parasitic roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.12
Grand average of hydropathy0.154
Instability index43.41
Isoelectric point8.27
Molecular weight130229.42
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06110
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.37|      22|      48|     646|     676|       1
---------------------------------------------------------------------------
  660-  704 (20.38/24.52)	FnnFQThALYCICIELMslsvsvvdvgnalitlaqfgRQKYRHIS
  709-  739 (30.99/14.23)	F..YQT.ILTTLCSDHM...........nsmntdvsnKLDFEKRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.80|      44|      52|     937|     988|       2
---------------------------------------------------------------------------
  937-  958 (19.11/ 7.81)	................................ALFPFFGtAAVDMVAQVVMRWF
  959- 1010 (61.84/46.16)	RLRDFSGLCWLLYVVFLIAVSIsrtyisaHfpDQV.ILG.IVVGICIALVTRSL
 1014- 1043 (42.86/20.90)	RRRQWSNLIAFMIVLLLIALSV.......H..EAHRFLG...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.47|      57|      84|     103|     159|       3
---------------------------------------------------------------------------
  122-  205 (78.43/47.61)	DTFAFFMENISLLDYKDLLNPQMRLLT.HVFMHYTYRDAiavllgtakpeksripyfeeviteiI....LELMFTaeCDHS......QLNPQAWR
  208-  267 (76.20/46.04)	STQIIYLTLQQSICFTRLV....KILH.TKLTHYPYRYA..................rnqlmwcL....FNFLSG..GMQK......YSGKNAWP
  268-  325 (54.84/31.00)	SP.ALVETYCRMLTYADLEILGLKQFTsHIVLTAA..............................rhqcCEMMYI..CCEIlnyrlfNIPS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.71|      18|      40|     499|     516|       4
---------------------------------------------------------------------------
  499-  516 (35.49/19.39)	ELSRASLTPNDCPL....PVY.F
  536-  558 (23.21/10.31)	ESPAACLKFLDSTLsilgPLYrF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.06|      27|     279|     561|     587|       5
---------------------------------------------------------------------------
  561-  587 (46.91/30.81)	YPVSFLY.....STF..RFYEKRLVEAPAIKQKL
  787-  816 (24.68/12.52)	....FLYvchlvAPFlqRFYQERTKFTMDITTDL
  841-  867 (37.46/23.04)	YHVKYMY...vgDSV..RQETDRII..PMLRTSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.42|      10|     302|     751|     760|       6
---------------------------------------------------------------------------
  751-  760 (22.20/15.92)	LA..LCH.AVWLH
 1052- 1064 (14.22/ 6.91)	LAakYCHrAEWIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.27|      23|     179|     881|     904|      13
---------------------------------------------------------------------------
  881-  904 (38.42/28.70)	QSGTPFSEMINPIKFLgIQMVVWL
 1065- 1087 (37.84/22.98)	QSTTPLASFFRDVGVL.ISIAVLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06110 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA