<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06092

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYSMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNILAKLASLLHCKMIDTYPLEDVLINDKFDQALASMNDVCEHFEHSVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGQKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTMQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLVLIVRNQFRKLNAVVTSTSSQILQFVLASRRLRATSRIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQ
Length1722
PositionHead
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.455
Instability index48.74
Isoelectric point5.54
Molecular weight195098.94
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06092
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     708.13|     167|     168|     896|    1062|       1
---------------------------------------------------------------------------
  736-  871 (67.91/37.48)	..............................................................................................................LQSDCDwsaDLDPLVKNgrgSNEapGCGSvskivngrmtttnccpadcdaLREDlrVAMEKLNATMGSIKSfwspELK....RER....ALRKEE.TA...KMNM...........................LQEQLKLSLvnnQKQSVLIEQLQNELRFQCNSGR.SRRFPDDGP
  896- 1062 (256.74/165.61)	SDAVKELQYQLES.................................QRQLLLSKDESVKRL...LEAL.HSKGVPA....SVAQSCAEM..ELAQNRIVEL...EEKCSRLQAHCD...DLESHLQQ...SHD..GLSS.....................LRKD..AVIESLQDEVASYEA....ELK....RLRSG.GAIHEREFTD...KMVT...........................DKEYQELKL...KADKLELELGQKTVEIQALYTRLSTAEESASD
 1065- 1247 (137.73/84.85)	........KHLEL.................................MKESNASKDQQATLLqsdIDAL.RGK.........L.ESKNEMidQKAQ.QITEL...QADKNRLLSELN...LLNEQHRI...SEV..GLST.......................KD..RKIDLLEETIRERDC....ELNlirtRLNSSpGVIQEKKLQDeinRLVQerdlwrkrfneeheclaierkrdgeahEKENKDLRI...AIASLQKEISDRQVFIESQNEKIND.......
 1282- 1476 (178.80/112.72)	NQAVDESRSEVDRllkiihnsekeknegresgndskrfhsntenadYQSVLMHKDRRIEEL...EEALkESVSITAeremAVAQQKLNS..QRAEQRIAAL...KDELKTMQEQYD...ELSIQLKQ...LRQ....EK.....................VQSD..ATIKTMQEERKRYVD....EVM....QLKGE.VLLAAIEEKD...AHIA..............................FLE.NF...HGRKSSEEIDNVKKQKEELLQRLK..EENA..
 1477- 1556 (66.95/36.83)	...............................................RRVKLHNDPTLNFT...DHFP.KVSGIDL.....VRHWWPAM..GIAWYDLVYLysdPEKSDR.Q...D...VLLDSLQT...ALD..NMDA.......................KQ..AGFFSLTSE...............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.89|      53|     279|     313|     455|       2
---------------------------------------------------------------------------
  395-  455 (80.65/152.03)	CPSLeTFQRDF...LIPQNPVVIEGALESwqameKWNIAYLMSKCAYRTvPiEIGSKYTNDE.........WS
  679-  743 (89.24/44.32)	CDGV.TFERCFdsqLPPADPQIHAGGFKS.....GFPFSARSSSNSYRQ.P.TLSSHLSHGNlgylqsdcdWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.10|      14|     436|     215|     228|       6
---------------------------------------------------------------------------
  215-  228 (26.26/19.02)	FTRTDLLSSCNVTS
  664-  677 (28.83/21.74)	FTRARHHSSCDVHS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06092 with Med20 domain of Kingdom Metazoa
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