<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06091

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYSMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNILAKLASLLHCKMIDTYPLEDVLINDKFDQALASMNDVCEHFEHSVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTMQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQ
Length1573
PositionHead
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.414
Instability index48.15
Isoelectric point5.43
Molecular weight177710.59
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.78|      19|      19|     859|     877|       1
---------------------------------------------------------------------------
  859-  877 (33.94/24.72)	RDWLISSD.AVKELQYQLES
  879-  898 (26.84/17.79)	RQLLLSKDeSVKRLLEALHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.27|      31|      84|    1008|    1040|       2
---------------------------------------------------------------------------
 1008- 1039 (46.25/30.42)	LESKNEMIDQKAQQiTELQADKNRLLSELNLL
 1094- 1124 (48.02/26.84)	IESQNEKINDMVRQ.TEALTKENSLYKELNKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     317.67|      79|     279|     918|     996|       3
---------------------------------------------------------------------------
  918-  985 (95.60/60.64)	..........................................................RIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELK....RLRSG...GAIHEREFT
  986- 1091 (46.79/25.49)	DKMVTDKEYQElklkidalrgklesknemidqkaqqitelqadknrllselnllneqhRISE.....................V..GLST..KDRKIDLLEETIRERDCELNlirtRLNSS..pGVIQEKKLQ
 1150- 1217 (79.67/49.17)	..........................................................RLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALK....ESVSI...TAEREMAVA
 1218- 1295 (95.60/60.64)	QQKLNSQRAEQ...............................................RIAALKDELKTMQEQYDELSIQLKQLRQ..EKVQSDATIKTMQEERKRYVDEVM....QLKGEvllAAIEEKD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      23|     223|     113|     139|       4
---------------------------------------------------------------------------
  113-  135 (40.23/20.01)	LGCP...DVLVCSAGVLIPKLLEDHS
  337-  362 (35.15/15.95)	LGCPisgNILAKLASLLHCKMIDTYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.69|      82|     219|     506|     629|       5
---------------------------------------------------------------------------
  510-  543 (23.89/71.08)	.............................................................VD..INAWFGPANTVsPLHTDP.RDNLfaQIDMEKID
  573-  626 (64.01/47.82)	GIACDVMSSAGSAAvQSSLASGLlpSPSNL.YYQSLGHITGG.EGISRN..GSRTPVS........................................
  676-  767 (123.79/78.80)	GFPFSARSSSNSYR.QPTLSSHL..SHGNLgYLQSDCDWSADlDPLVKNgrGSNEAPGcgsVSkiVNGRMTTTNCC.PADCDAlREDL..RVAMEKLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.60|      14|     415|     215|     228|       8
---------------------------------------------------------------------------
  215-  228 (26.52/14.77)	FTRTDLLSSCNVTS
  633-  646 (29.08/16.86)	FTRARHHSSCDVHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06091 with Med20 domain of Kingdom Metazoa
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