<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06089

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYSMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNILAKLASLLHCKMIDTYPLEDVLINDKFDQALASMNDVCEHFEHSVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGQKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQVRCEISVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTMQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQ
Length1739
PositionHead
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.458
Instability index47.76
Isoelectric point5.49
Molecular weight197001.09
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06089
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     810.63|     219|     223|     973|    1195|       1
---------------------------------------------------------------------------
  791- 1067 (274.67/232.50)	RVaMEKLNATMGSIKSFWSPELKrerALRKEETAKMNML.QEQLKLSLVNNQKQSVLIE.QLQNELRFQCNSG.RSRRfpDDG.PLIgHEDYRTV......CqERDMYRRDWLISSDAVKELQYQLESQRqLLLSKDESVKRLlealhskgvpasvaqscaemelaqnriveleekcsrlqahcddleshlqQ.SHDGLSSlrkDAVIESLQDEVASYEAELKRLRSG...GAIHERE....FTDKMV.........TDKEYQ.ELKLKADKLELELGQKT..VE.IQALYTRLSTA.EESASDFKKHL
 1068- 1296 (291.39/243.15)	EL.MKESNASKDQQATLLQSDID...ALRGKLESKNEMIDQKAQQITELQADKNRLLSElNLLNEQHRISEVG.LSTK..DRKIDLL.EETIRER.....DC.ELNLIRTRLNSSPGVIQEKKLQDEINR.LVQERDLWRKRF................................................nE.EHECLA.......IERKRDGEA.HEKENKDLRIA...IASLQKE....ISDRQVfiesqnekiNDMVRQtEALTKENSLYKEL.NKTngVDlLKAEIERLNQAvDESRSEVDRLL
 1297- 1498 (244.57/198.09)	KI.IHNSEKEKNEGR...ESGND...SKR..FHSNTENADY........................QVRC.EISvLMHK..DRRIEEL.EEALKESvsitaER.EMAVAQQKLNSQRAEQRIAALKDELKT.MQEQYDELSIQL................................................kQlRQEKVQS...DATIKTMQEERKRYVDEVMQLKGEvllAAIEEKDahiaFLENFH.........GRKSSE.EID.NVKKQKEELLQRL..KE.ENA..RRVKLH.NDPTLNFTDHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.12|      56|     276|     313|     458|       2
---------------------------------------------------------------------------
  395-  458 (85.37/172.06)	CPSLeTFQRDF...LIPQNPVVIEGALESwqameKWNIAYLMSKCAYRTvPiEIGSKYTND.........EWSQKL
  679-  746 (93.75/59.78)	CDGV.TFERCFdsqLPPADPQIHAGGFKS.....GFPFSARSSSNSYRQ.P.TLSSHLSHGnlgylqsdcDWSADL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     295.29|      90|     434|     136|     228|       5
---------------------------------------------------------------------------
  136-  228 (151.27/121.67)	DVEIYRTMNTIRaFYPYILKRGQGHIVA.VSSYGGHFGNSYSCCYSASKFAvRGLMESlEWEIYDHGFGGEIKTTTIYPF.............FTRTDLLSSCNVTS
  574-  677 (144.02/102.40)	DYEKFPLVKNVK.FYETIVKPGDLLFIPkATGIACDVMSSAGSAAVQSSLA.SGLLPS.PSNLYYQSLGHITGGEGISRNgsrtpvsqrrvghFTRARHHSSCDVHS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06089 with Med20 domain of Kingdom Metazoa
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