<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06088

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYSMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNILAKLASLLHCKMIDTYPLEDVLINDKFDQALASMNDVCEHFEHSVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGQKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDISDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKGVPASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQSVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTMQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQ
Length1733
PositionHead
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.449
Instability index47.24
Isoelectric point5.45
Molecular weight195975.88
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06088
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     466.40|     157|     209|     220|     395|       1
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  220-  395 (226.35/215.68)	LLSSCNVTSdvIPV.....LTPEETSQGILKAILYEQtEAFIPfYGSLICYFFKGRTFKAI.ELEDFEAAVEICNFMLNTghwSEVNI.SWRLLYSMVSLLLS......IAHIAnGR..LKdaLC..SCDKGLLlgcPISGNILAKLASLLHCKM.IDTYPL.EDVlindKFDQALASMNDVCehFEHSVPRVEC
  432-  607 (240.06/165.29)	LMSKCAYRT..VPIeigskYTNDEWSQKLLTVTDFVH.EYFNP.DAREKAYLAQHQLFEQItELKDDIAVPDYCCLQCAP...EDVDInAWFGPANTVSPLHTdprdnlFAQVF.GQkyLR..LChpTATKNLY...PITDGLMSNTSQIDMEKIdYEKFPLvKNV....KFYETIVKPGDLL..FIPKATGIAC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     599.16|     140|     140|     980|    1119|       2
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  853-  960 (114.90/64.88)	.............................ELR....FQCNS.G..RS.RRFPD.dgPLI.....GHEDY............................RTVCQERD.ISDAVKELQYQLES.....QRQLL..LS...KDesvkrlLEALHSKgvpasvAQSCAEM.ELAQNRIVELEEKCSRLQAHCDDLE
  980- 1119 (215.69/128.65)	ES.................LQDEVASYEAELK....RLRSG.GAIHE.REFTD...KMV.....TDKEYQELKLKA.DKLELELGQKTVEIQA.LYTRLSTAEES.ASDFKKHLELMKESNASKDQQATL..LQ...SD......IDALRGK......LESKNEMIDQKAQQITELQADKNRLLSELNLLN
 1120- 1261 (135.09/77.65)	EQhrisevglstkdrkidlLEETIRERDCELNlirtRLNSSpGVIQE.KKLQDeinRLV..........QERDLWR.KRFNEE...................HEClAIERKRDGEAHEKEN..KDLRIAIasLQ...KE......ISDRQVF......IESQNEKINDMVRQ.TEALTKENSLYKELNKTN
 1264- 1394 (133.48/76.63)	DL.................LK.......AEIE....RLNQ...AVDEsRSEVD...RLLkiihnSEKEKNEGRESGnDSKRFHSNTENADYQSvLMHKDRRIEEL.EEALKESVSITAEREMAVAQQKLN..SQraeQR......IAALKDE......LKTMQEQYDELSIQLKQLRQEK...........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.49|      21|     285|     400|     420|       4
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  400-  420 (38.48/24.26)	TFQRDF...LIPQNPVVIEGALES
  683-  706 (37.01/23.05)	TFERCFdsqLPPADPQIHAGGFKS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.77|      31|      34|    1398|    1431|       6
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 1400- 1431 (45.99/34.22)	TIKTMQE..ERKRY..VDEVMQLKGEvLLAAIEEKD
 1433- 1467 (40.77/19.75)	HIAFLENfhGRKSSeeIDNVKKQKEE.LLQRLKEEN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.54|      50|     655|      99|     158|       7
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   99-  158 (76.13/66.19)	SMRQVANAIVTNPELgCP.DvlvCSAgvlipkLLED.HSDVE.IYRTMNTIRAFYPYILKRGQ
  764-  816 (79.41/45.85)	SVSKIVNGRMTTTNC.CPaD...CDA......LREDlRVAMEkLNATMGSIKSFWSPELKRER
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06088 with Med20 domain of Kingdom Metazoa
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