<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06087

Description Lysine-specific demethylase 8
SequenceMILLVRIGLALLQCCFGYTWSILECFFKKPKSVTDKVIVITGAARGIGKGLALLLAHLHAKIVLVDLDESTNKQTAEELRQETSACVYAYTADVTDPESMRQVANAIVTNPELGCPDVLVCSAGVLIPKLLEDHSDVEIYRTMNTIRAFYPYILKRGQGHIVAVSSYGGHFGNSYSCCYSASKFAVRGLMESLEWEIYDHGFGGEIKTTTIYPFFTRTDLLSSCNVTSDVIPVLTPEETSQGILKAILYEQTEAFIPFYGSLICYFFKGRTFKAIELEDFEAAVEICNFMLNTGHWSEVNISWRLLYSMVSLLLSIAHIANGRLKDALCSCDKGLLLGCPISGNILAKLASLLHCKMIDTYPLEDVLINDKFDQALASMNDVCEHFEHSVPRVECPSLETFQRDFLIPQNPVVIEGALESWQAMEKWNIAYLMSKCAYRTVPIEIGSKYTNDEWSQKLLTVTDFVHEYFNPDAREKAYLAQHQLFEQITELKDDIAVPDYCCLQCAPEDVDINAWFGPANTVSPLHTDPRDNLFAQVFGQKYLRLCHPTATKNLYPITDGLMSNTSQIDMEKIDYEKFPLVKNVKFYETIVKPGDLLFIPKATGIACDVMSSAGSAAVQSSLASGLLPSPSNLYYQSLGHITGGEGISRNGSRTPVSQRRVGHFTRARHHSSCDVHSLCDGVTFERCFDSQLPPADPQIHAGGFKSGFPFSARSSSNSYRQPTLSSHLSHGNLGYLQSDCDWSADLDPLVKNGRGSNEAPGCGSVSKIVNGRMTTTNCCPADCDALREDLRVAMEKLNATMGSIKSFWSPELKRERALRKEETAKMNMLQEQLKLSLVNNQKQSVLIEQLQNELRFQCNSGRSRRFPDDGPLIGHEDYRTVCQERDMYRRDWLISSDAVKELQYQLESQRQLLLSKDESVKRLLEALHSKASVAQSCAEMELAQNRIVELEEKCSRLQAHCDDLESHLQQSHDGLSSLRKDAVIESLQDEVASYEAELKRLRSGGAIHEREFTDKMVTDKEYQELKLKADKLELELGQKTVEIQALYTRLSTAEESASDFKKHLELMKESNASKDQQATLLQSDIDALRGKLESKNEMIDQKAQQITELQADKNRLLSELNLLNEQHRISEVGLSTKDRKIDLLEETIRERDCELNLIRTRLNSSPGVIQEKKLQDEINRLVQERDLWRKRFNEEHECLAIERKRDGEAHEKENKDLRIAIASLQKEISDRQVFIESQNEKINDMVRQTEALTKENSLYKELNKTNGVDLLKAEIERLNQAVDESRSEVDRLLKIIHNSEKEKNEGRESGNDSKRFHSNTENADYQVRCEISVLMHKDRRIEELEEALKESVSITAEREMAVAQQKLNSQRAEQRIAALKDELKTMQEQYDELSIQLKQLRQEKVQSDATIKTMQEERKRYVDEVMQLKGEVLLAAIEEKDAHIAFLENFHGRKSSEEIDNVKKQKEELLQRLKEENARRVKLHNDPTLNFTDHFPKVSGIDLVRHWWPAMGIAWYDLVYLYSDPEKSDRQDVLLDSLQTALDNMDAKQAGFFSLTSETFFSTTTTNAKPVHLFQSSEFPETTFVLVGDTLGSASTFLFAEKSITQMIRNLDGAYCTKPISKVECRGNKYVISDFTVRTSVATIASNFKGILVEIEYRPCVAMQLCGDLMKEFCTALLGSAASAPPTFVGLTKPNQRYVPIDTIFQKMSVQTAGPNEQQSQAQPQPQQQQQQQPQQQQQQQQQ
Length1743
PositionHead
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.451
Instability index47.22
Isoelectric point5.47
Molecular weight197431.58
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
methyltransferase activity	GO:0008168	IEA:UniProtKB-KW
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
methylation	GO:0032259	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06087
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     668.86|     189|     223|     909|    1131|       1
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  915- 1109 (290.58/190.51)	SKDESVKRLLEALHSKAS........VAQSCAEMELAQNR.......IVE..LEEKCSRLQAHCDDLESHLQQSHDGLSsLRK.....DAVIESLQDEVASYEAELKRLRSG...GAIHERE....FTDKMV.........TDKEYQ.ELKLKADKLELELGQKT..VE.IQALYTRLSTA.EESASDFKKHLELMKESNASKDQQAtllQSDIDALRgkLESKNEMIDQKAQ.QITEL
 1139- 1334 (223.69/157.30)	...RKIDLLEETIRER.............DC.ELNLIRTRlnsspgvIQEkkLQDEINRLVQERDLWRKRFNEEHECLA............IERKRDGEA.HEKENKDLRIA...IASLQKE....ISDRQVfiesqnekiNDMVRQtEALTKENSLYKEL.NKTngVDlLKAEIERLNQAvDESRSEVDRLLKIIHNSEKEKNEGR...ESGNDSKR..FHSNTENADYQVRcEISVL
 1336- 1484 (154.58/79.19)	HKDRRIEELEEALKESVSitaeremaVAQQKLNSQRAEQR.......IAA..LKDELKTMQEQYDELSIQLKQ.......LRQekvqsDATIKTMQEERKRYVDEVMQLKGEvllAAIEEKDahiaFLENFH.........GRKSSE.EID.NVKKQKEELLQ.............RLK...EENARRVKLH...............................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     929.37|     251|     277|     313|     578|       2
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   99-  306 (223.78/118.87)	...................................................................SMRQVAN....AI....VTN.PELG..CPDVLVCSAGV...LIP.K..LLEdhSDVEIYRTMNTIRafYPYILKRGQGHIVAVsSYGGHFGNS.........YsccYSASKFAVRGLM.ESLEW...EI....Y..DHGF...GGEIKTTTIYPFFTrtdLLSSCN..VTSDV.....IPVLTPEETS.QGIL...KAILYEQteAFIPFYGSLiCYFFKGRTFK..AIELedfeaaveicNFMLNTGH.WSEVNISWR.LL
  313-  578 (406.74/259.73)	LLSIAHiANGrlkdalCSCDkglLLGCPISGNILAKLASLLHCKMIDTY..PLEDVLINDKFDQAlASMNDVCE....HF....EHSVPRVE..CPSLETFQRDF...LIPQNPVVIE..GALESWQAMEKWN..IAYLMSKCAYRTVPI.EIGSKYTND.........E...WSQKLLTVTDFVhEYFNP...DAREKAYLAQHQLFEQITELKDDIAVPDYC...CLQCAP..EDVDI.....NAWFGPANTV.SPLHtdpRDNLFAQ..VFGQKYLRL.CHPTATKNLY..PITD..........GLMSNTSQ.IDMEKIDYE.KF
  596-  856 (298.85/164.62)	LLFIPK.ATG......IACD...VMSSAGSAAVQSSLASGLLPSPSNLYyqSLGHITGGEGISRN.GSRTPVSQrrvgHFtrarHHSSCDVHslCDGV.TFERCFdsqLPPADPQIHA..GGFKS.....GFP..FSARSSSNSYRQ.P..TLSSHLSHGnlgylqsdcD...WSADL...........DPlvkNGRGSNEAPGCGSVSKI..VNGRMTTTNCC...PADCDAlrEDLRVameklNATMGSIKSFwSP...........E..LKRERALR..KEETAKMNMLqeQLKL..........SLVNNQKQsVLIEQLQNElRF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06087 with Med20 domain of Kingdom Metazoa
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