<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06080

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEEEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHGEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIENVDFNYFKDSDESKLDFDKIIDFADKKAISSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWNKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKASVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQETMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2101
PositionKinase
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.271
Instability index48.41
Isoelectric point6.59
Molecular weight238245.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06080
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.86|      80|     191|     808|     887|       1
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  808-  887 (138.55/81.13)	LLGLLEESSNFISLVEFVEAIICLLPKLEAQ..IVERNFQCANSLTLQYAVC..MVGY.MRKHH.............CY......FIQLESVMCNIWRSLLLYV
  893-  954 (77.75/42.21)	VNSFSAER..............CVWVYLHDL.......YQC..........C....SY.IRSLHadlylnsrdciqrCL......CVETKPSCCNDLRTLLADV
  997- 1087 (115.56/66.41)	LCGLSGDTERLFNLVLFCADVTALCPNLNADwlAVFKILCCPFNSSQDQSSCdsLLNIdVSDHQ.............CYqpltvlVITLISRMCIRLEDFILHV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     103.35|      19|      36|    1760|    1778|       2
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 1760- 1778 (33.58/19.44)	VPP.MVQNRQ.L.GIG..QPTLTA
 1797- 1817 (27.41/14.33)	VPP.YGQGQM.W.SIGnvQSASTA
 1818- 1838 (20.32/ 8.48)	VPPtQYQSRN.FtGAQ..MTPVQS
 1845- 1864 (22.04/ 9.90)	ISA.MIRGRRpS.GSG..GQQMMT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     241.56|      53|      83|    1955|    2009|       3
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 1901- 1954 (45.27/22.70)	.......QMQMdarqqlmqetmmeqqqirTPGPR.....SMATQQ......HC..LPQVNS....AASQPVMHGNYSN
 1956- 2008 (104.32/71.20)	PGQHGGGRMQM..................TSGRN.....QYAAQQPAQPPFNC..SPNYNAQFYQAQNAGQMRMSQTD
 2021- 2068 (53.12/33.89)	PNAIGSS.YQM..................QSQQTlrapaGYVAQQ.ANPMYAApnTPQYQAA..QQQNVS........
 2069- 2100 (38.85/20.78)	........MYP..................VSRMS.....QYSSNVPGQE.MNA..S.QQQINYYPPQ...........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.01|      47|      86|     564|     634|       4
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  564-  634 (61.89/79.66)	LLFSRLIEsdiFSHDQYVS..TlvssgdlipnganifyplqNQCSSAAVENVS.....................NTQPAVLMSSNffSEQF..KPI
  650-  721 (60.12/33.17)	LDFDKIID...FADKKAISsdT...................DSCSSKRVPKLSkhyfnvlhfpvpqddqyrhecNQRQLLLFGSN..SDQYsrKHI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.27|      24|      26|    1370|    1393|       5
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 1370- 1393 (42.28/27.98)	FVQGRVLKAS...VSILENCQARRDRN
 1395- 1421 (33.14/20.13)	FVQSSSLLAHqpfLSLVLICLRGQDDQ
 1436- 1451 (25.84/13.87)	FVM.RV.KED...PYIL..CD..RD..
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.25|      53|      67|    1509|    1564|       6
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 1509- 1564 (83.72/63.10)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRIYNNviKKLKVKEI..G.DRQVPSLR
 1577- 1633 (81.53/50.89)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQIIGK..EKLNPWEIieGyNRENIGLK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     373.18|     114|     191|     131|     252|       7
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  131-  252 (184.77/156.56)	PFlnkKDEILYTLAefNVpmVRVVwFLKMTNAHIAQQQEC...GKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLE..VPMNSE.FECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIF
  328-  447 (188.41/131.75)	PF...HRTVLFGLS..NV..IHAV.LIDCPTALIWNEMECedtGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFVKKELErlTEMVTErSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.11|      29|     660|    1208|    1242|       8
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 1163- 1192 (40.38/20.21)	IAILML....DDSKVQELKSKENFDTKRsAAKQF
 1210- 1242 (45.74/41.70)	IQLLELicrqEWTKRKFLHSTDLFDPKR.LLNPL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.35|      16|     660|      62|      77|       9
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   62-   77 (27.64/17.99)	KLTQSYNAIVNKK..AEI
  724-  741 (23.70/14.35)	KLTKELNKLWNKKtsAEL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.48|      34|      36|    1261|    1296|      10
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 1258- 1293 (49.35/32.15)	SDSEILLKKFDSCTTKK.ELISKVLDSltIMNLWVSQ
 1294- 1328 (51.13/27.93)	MDLQLLLKQVANSQSESlHLVDTIAKS..CMEVFQPQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.23|      24|      36|     745|     770|      11
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  745-  770 (30.73/25.93)	GLIRVRKIIDSESLCsLSrKIQNLVF
  784-  807 (43.51/26.30)	GIAQFNSFISGQSNC.LP.TLENFDF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.22|      21|      36|    1699|    1720|      12
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 1699- 1720 (30.04/29.39)	KLTTERlKSNGPVAISGGTLVS
 1738- 1758 (33.18/26.42)	KSTRGR.KTSSRVTVSSNVALS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.39|      34|     494|     959|     995|      18
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  959-  995 (46.58/47.73)	MLDVLFQESDLViePNLIQRLVENANLcYAFAIVAVK
 1456- 1489 (59.81/45.53)	MLDALQLRLSLI..GGMFDTVCRNANL.ENWSLVMVQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06080 with Med12 domain of Kingdom Metazoa
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