<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06079

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHFFIAPLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLFEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEEEEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFVKKELERLTEMVTERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQEVKHGEFQLSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIENVDFNYFKDSDESKLDFDKIIDFADKKAISSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWNKKTSAELTTTGLIRFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKASVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKVKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQETMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQMRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2076
PositionKinase
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.272
Instability index48.34
Isoelectric point6.54
Molecular weight235308.23
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06079
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     498.76|      82|      82|    1716|    1797|       1
---------------------------------------------------------------------------
 1643- 1712 (57.04/31.24)	.....................PPMPGEPR.SDPF..LETLQVHYLPCTNET.SdsdkLTTerlksnGP...VAISG.GT.....L.VSefSDQVQSPR..TTKARAR
 1716- 1797 (143.16/91.51)	RGRKTSSRVTVSSNVALSS.VPPMVQNRQ.LGIG..QPTLTAHYGYYPQQV.A....MTG......GPSGAVPPYGQGQ.....M.WS..IGNVQSAS..TAVPPTQ
 1801- 1876 (102.54/63.08)	RNFTGAQMTPVQSSSGKQA.ISAMIRGRRpSGSGgqQMMTTAHI.....QA.A..............PLATGQPYHQQQ.....L.HS..IGQVDPMV..APMHQVQ
 1890- 1959 (93.94/57.06)	MMEQQQIRTPGPRSMATQQhCLPQVNS....AAS..QPVMHGNYSNYPGQ........HG......G..........GR.....MqMT..SGRNQYAAqqPAQPPFN
 1976- 2058 (102.08/62.76)	QMRMSQTDVIGQSNVRYTQ.QPNAIGSSY.QMQS..QQTLRAPAGYVAQQAnP....MYA......APN..TPQYQAAQqqnvsM.YP..VSRMSQYS..SNVP...
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.86|      80|     191|     783|     862|       3
---------------------------------------------------------------------------
  783-  862 (138.55/95.48)	LLGLLEESSNFISLVEFVEAIICLLPKLEAQ..IVERNFQCANSLTLQYAVC..MVGY.MRKHH.............CY......FIQLESVMCNIWRSLLLYV
  868-  929 (77.75/49.67)	VNSFSAER..............CVWVYLHDL.......YQC..........C....SY.IRSLHadlylnsrdciqrCL......CVETKPSCCNDLRTLLADV
  972- 1062 (115.56/78.15)	LCGLSGDTERLFNLVLFCADVTALCPNLNADwlAVFKILCCPFNSSQDQSSCdsLLNIdVSDHQ.............CYqpltvlVITLISRMCIRLEDFILHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     397.01|     124|     189|    1188|    1316|       4
---------------------------------------------------------------------------
  230-  304 (47.51/21.48)	.........TRHLF..EEGLLDKEMLLNGLL.difaEKIYASSfgILKMLvpvlLQFIDGFVM........SVLLSRRLVylaCKVLSAMKI...............DNL..............................................................
 1188- 1316 (194.18/131.38)	LElICRQEWTKRKFLHSTDLFDPKRLLNPLV.....NQTQAQR..LLRMI....TRSDSEILLK....KFDSCTTKKELI...SKVLDSLTI...............MNL..WvSQMDLQLLLKQ.VANSQSESLHL..VDTIaksC...MEVFQP.QATLAF.GEPSDDKD
 1358- 1513 (155.32/92.29)	LE.NCQARRDRNLFVQSSSLLAHQPFLSLVLiclrgQDDQREG..LLSSL....LKQIQEFVMRvkedPYILC..DRDIV...SEMLDALQLrlsliggmfdtvcrnANLenW.SLVMVQLLLYGiVTEEKNQALFYtcVDIL...CvllLSCLLPdSAGFSFsGQERTNED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.63|      87|     189|     131|     225|       5
---------------------------------------------------------------------------
  131-  225 (140.44/113.74)	PFlnkKDEILYTLAefNVpmVRVVwFLKMTNAHIAQQQEC...GKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLE..VPMNSE.FECHYRHWQY
  328-  420 (143.19/90.30)	PF...HRTVLFGLS..NV..IHAV.LIDCPTALIWNEMECedtGENGKAYLCGSPLDLLYCSPVDLPLFMDPSTEFVKKELErlTEMVTErSRAVESHWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.36|      90|     188|     449|     543|       7
---------------------------------------------------------------------------
  449-  543 (143.50/122.07)	FEYVNETNN..IDtLYKTIFQSEKKEMRVDVDSIAVQFLCHwaVSPHRYGSYRAAVVTRLFERHlqEVKHGEFQL..SKKMPQVRHPFQKSL...FNYLHNQ
  639-  735 (142.86/102.59)	FNYFKDSDEskLD.FDKIIDFADKKAISSDTDSCSSKRVPK..LSKHYFNVLHFPVPQDDQYRH..ECNQRQLLLfgSNSDQYSRKHILKKLtkeLNKLWNK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06079 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGI
2) IGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQETMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPP
3) RMLPHDHHHAFNRPPMPGEPRSDPFLETLQ
1691
1783
1630
1746
1957
1659










Molecular Recognition Features






MoRF SequenceStartStop




1) YYPPQY
2071
2076