Description | Mediator of RNA polymerase II transcription subunit 6 (Fragment) |
Sequence | LNMNVHGSSQITNPLHIQWNPPWNPNWLSASNVLDCFTNTLNPFYDPNCLNEQVRIQRLSSEILSRVHGVEYILLHAAEPLFVIRKQYRQPNQNVTPLEDYYIIGGTVYQAPDLSSVFNSRLQSAISNVRSAFEEGIRFFSYFNAKVTCDCFCIIAKSYYRFNTSDGYYFKYKNEPPVEKVDTKKDDKTGDDKRVSVFQKYRMDMLLNELSEKFPPALSLEESNENTQDGKMTSNEEPQTSAQSKNDQMESPALSASKKIKSDMN |
Length | 265 |
Position | Head |
Organism | Trichinella sp. T6 |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella. |
Aromaticity | 0.11 |
Grand average of hydropathy | -0.651 |
Instability index | 42.38 |
Isoelectric point | 5.67 |
Molecular weight | 30461.78 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06078 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 111.18| 36| 60| 163| 205| 1 --------------------------------------------------------------------------- 163- 205 (53.75/43.87) NTSDGyyfkyK...NEPPVEKVDTKKDDKtgDDKRVSVFQKYRMDM 226- 264 (57.43/29.83) NTQDG.....KmtsNEEPQTSAQSKNDQM..ESPALSASKKIKSDM --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MLLNELSEKFPPALSLE 2) NDQMESPALSASKKIKSDMN 3) YYFKYK | 205 246 168 | 221 265 173 |
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