<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06063

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLLMILSVNCAITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLHTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRLTPLSMLSSYKLTLVYGPMLRYVCHLQWKPNEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHDSLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1304
PositionTail
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.003
Instability index43.80
Isoelectric point6.05
Molecular weight148050.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.53|      23|      54|     437|     459|       1
---------------------------------------------------------------------------
  124-  147 (23.75/ 9.77)	FVDTADrlYQMN......CDvlqnaRLPVF
  437-  459 (43.65/23.73)	FTETLD..LSMNLFTGKFVC.....RLPAF
  493-  515 (44.13/24.07)	FVNRID..HTMRFFTLKSCE.....TLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.37|      22|     366|     296|     324|       2
---------------------------------------------------------------------------
  296-  324 (34.01/32.98)	FCLSAQLDI.LCCQAYRLIgdfmsenLSVE
  667-  689 (37.35/20.28)	FGLPKGLAIgLSCDRHRVV.......WSIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.46|      81|     808|     347|     434|       3
---------------------------------------------------------------------------
  347-  434 (119.90/102.29)	SFKVIFWINQDEPFAPLQVTHIPKSELKLPSMD.TESGQLSLDNLLTETVLIrVKHRLQQlcDFLHTIKGLTctfISDmPA..LSITFLPD
 1157- 1240 (135.57/88.59)	SFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQlVPTTYLSRATLMPGGLAI.VANVVQK..KMLFWIKFVR...VAD.PShcVAFPFLYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.38|      89|     633|     155|     253|       4
---------------------------------------------------------------------------
  155-  253 (133.25/123.35)	VLTLGTYprlPSVIKREFIRtadISQEEEEC..VLHRLNYVIERRLLPSLL.TLPEGMRNFTVNNGMVtFHVAGEFEA.QLTLLGQ....LPRTPWTllnLRILVSD
  793-  889 (135.13/95.58)	ILSFGVD...NSVLNEEYVY...FNPHSILCghLQHWFNAVRDISALAHLLqASSAALQALTTLPDTI.FRVGSEHTSnQMLYLNRmfsiLPTGPDT...VRLLCKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.62|      81|     463|     543|     626|       5
---------------------------------------------------------------------------
  543-  626 (134.21/94.26)	LTFND.HPDDSAKVNLDFWLVCN...ETVSNA.IRSADADDDVRSKKNVNLLHFDLRRVVSEtKVKKQC....VIPElmAAFSM.C.ENAMPFFL
 1001- 1092 (121.41/75.46)	LANDDgHAEPSSRSPPEDWTPCVvpiEIQQNAfIRICSPSGTHPHPEWSHLQKFILSVEVLE.KMKEQAnnftVIRP..GQLSLkCnQSEMKFFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.23|      16|     243|     474|     489|       6
---------------------------------------------------------------------------
  474-  489 (32.00/20.28)	DDSHWNCLEDLLHQIR
  720-  735 (27.23/16.13)	NESARKCLDDVLSGVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06063 with Med14 domain of Kingdom Metazoa
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