<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06057

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLLMILSVNCAITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLHTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFGNKLHVNLVVVYGSLELFRRFITPNSVFFPFNFFVYGNEFLNFSVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRLTPLSMLSSYKLTLVYGPMLRYVCHLQWKPNEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHDSLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1318
PositionTail
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.10
Grand average of hydropathy0.024
Instability index42.87
Isoelectric point6.32
Molecular weight149677.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06057
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.87|      75|     131|    1041|    1124|       1
---------------------------------------------------------------------------
 1041- 1124 (116.37/77.98)	EIQQNAFIRicsPSGTHPHPEWSHLqkfILSVEVLEkmKEQANNFTVIrPGQLSLKCN..QSEMKF...FLNESNLS.SVMFKFFRD.END
 1177- 1258 (119.50/59.14)	NIQQHAYVE...SSTAYWIPEMCFL...IPSPQLVP..TTYLSRATLM.PGGLAIVANvvQKKMLFwikFVRVADPShCVAFPFLYDgENN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.78|      48|     131|     433|     486|       4
---------------------------------------------------------------------------
  369-  420 (54.95/25.01)	PKSELklpsmdTESGQLS...........LdNLLTETVLIRVKHRLQQLCDFLHTIKGLTCTF...
  433-  480 (84.16/44.47)	PDSSF......TETLDLS...........M.NLFTGKFVCRLPAFGNKLHVNLVVVYGSLELFRRF
  489-  543 (60.68/37.41)	PFNFF...vygNEFLNFSvrifvnridhtM.RFFTLKSCETLPAF.......LKTACEQWPVDRRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.68|      10|      73|     156|     165|       8
---------------------------------------------------------------------------
  156-  165 (20.74/14.16)	LT.LGTYPRLP
  231-  241 (15.94/ 8.89)	LTlLGQLPRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      25|     647|      76|     103|       9
---------------------------------------------------------------------------
   76-  103 (40.63/44.56)	RKISIAQFA...HSARQLfvrLYAILKWARC
  723-  750 (40.28/32.80)	RKITILSCTvgnESARKC...LDDVLSGVRC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06057 with Med14 domain of Kingdom Metazoa
Unable to open file!