<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06054

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEEYEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANRIVDFFVRNVTQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNATSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNCDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQPQQPQQQQQPQPQQSNVVVGSSQQPQQQQQSRFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERNWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTVMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDHMNSINTDVSNKLDFEKRSKLMEDCYAARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEEQFLYVCHLVAPFLQRFYQERTKFTMDITTDLYQMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQVGKGSFEEDFTSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAALDMVIVGAFSEISNCILKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSVSRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHQSTTPLASFFRDVGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPIGRLPTALFYGMLFVEHFFCFFTTAVLLPVLFTNNSNKLQ
Length1745
PositionTail
OrganismTrichinella sp. T6
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.12
Grand average of hydropathy0.075
Instability index45.77
Isoelectric point7.36
Molecular weight200758.46
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06054
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.16|      18|      18|     760|     777|       1
---------------------------------------------------------------------------
  760-  777 (36.82/19.71)	QQQQQQQQQQQQQQQQQQ
  778-  795 (36.43/19.43)	QQPQQPQQQQQPQPQQSN
  800-  817 (30.92/15.53)	SSQQPQQQQQSRFLLKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.41|      47|      80|     914|     963|       2
---------------------------------------------------------------------------
  914-  963 (77.00/58.46)	VPLERFMLT...MLLRDYEGNDAFYALLIVMLLVQRseeLRSAVADCVAMLPS
  992- 1041 (78.41/51.84)	VELSRASLTpndCPLPVYFGTRCLQMLPVVDLLLQK...LVESPAACLKFLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.89|      37|      80|    1428|    1464|       3
---------------------------------------------------------------------------
 1428- 1464 (64.77/31.26)	QHFWLAVTKLGDP....VMTFSLYFPALFPFFGTAALDMVI
 1467- 1495 (31.19/11.62)	.....AFSEISNC....ILKWILLDDRPYWWVHTAGVS...
 1504- 1540 (46.56/20.61)	QFQWTCETGPGSPsghaMVSASVWFNLLYNL....QSDLVL
 1545- 1574 (44.37/19.33)	GICWLLYVVFLIA....VSVSRTYISAHFP.......DQVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      85|     273|     287|       4
---------------------------------------------------------------------------
  273-  287 (28.85/18.34)	RLLTHVFMHYTYRDA
  355-  369 (28.86/18.35)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.50|      43|      85|     112|     154|       5
---------------------------------------------------------------------------
   89-  127 (61.58/39.21)	VRNVTQRQMLSIKCICEKLLTC..........................................aELNINSC..GW..NDTF.AFF
  128-  212 (46.10/27.22)	MENISLLDYKGVRDTLKRLLDIPIPVHlqvdqrksveaveklikticdrknnllpayfviteiikNLPEQRCfsHWrmADCF.TEI
  213-  246 (55.82/34.75)	IE..SFRPLAQLNSVCGRTFMTPIPGH.........................................V.....GF....YFnAFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.87|      16|      29|     579|     595|       6
---------------------------------------------------------------------------
  579-  595 (26.75/25.89)	CRMLtYPDLEILGLKQF
  609-  624 (34.12/27.26)	CEMM.YICCEILNYRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.05|      18|      29|     297|     319|       7
---------------------------------------------------------------------------
  297-  319 (26.53/31.53)	PEKSRIpyfeeVITEIIL.....ELMFT
  329-  351 (28.52/17.35)	PQAWRI.....ISTQIIYltlqqSICFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.52|      49|      84|    1576|    1624|       8
---------------------------------------------------------------------------
 1576- 1624 (80.14/58.07)	GIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGV
 1658- 1706 (76.38/54.95)	GVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVGLNQLVAFIPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.37|      73|      84|    1156|    1238|       9
---------------------------------------------------------------------------
 1156- 1238 (114.11/89.93)	QTHALYSICIELMslpvgvVDVGNALVTLVTH..W.HS......LVDKNTVMYWVNAIGlifSALPISYM....EPFYQTILTTLCSDHMNsINTD
 1240- 1325 (109.25/64.28)	SNKLDFEKRSKLM......EDCYAARILALCHavWlHStsgylqLLPQALRSTWIPHVR...SEEQFLYVchlvAPFLQRFYQERTKFTMD.ITTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.18|      21|      38|     456|     480|      12
---------------------------------------------------------------------------
  456-  480 (33.94/29.99)	EALKNKTQFN....TDNYMvavlCNAYSS
  495-  519 (32.24/19.12)	ENLDNTRGHNstqaSGNFA....SNATSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06054 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQQQQQQQQQPQQPQQQQQPQPQQSNVVVGS
765
800










Molecular Recognition Features






MoRF SequenceStartStop




NANANA