<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06048

Description Aromatic-L-amino-acid decarboxylase
SequenceMDAEEFRKWGKKMIDFVADYWINLPSRTPMSDVKPGYLRSLLPEEAPMDPDSWENIFSDIETVILQGTTHWHHPLFFAYYPTGNSYPAILGDILSAGIGCIGFTWNSSPACTELEMVMMDWLAKLLKLPEYFLYSHSGPGAGMIQAHSSVERAAMLAHVQIRKVPSDENYRMTRVALQAVIENDINAGFIPFFVCATLGTTNSCAFDCLTEIGLLCKEKEIWLHIDAAYAGSAFICPEYRHLLDGIEYADTFNFNPHKALMINFDCSAMWFKNVLEIENAYYVNPQYLKHEHQNMIPDFRNWQIPLGRRFRSLKLWLTFRSLGVGFLQENIRKMCRLAKEFADFVVKDERFELVAPVILGLVCFRLKTRDSSGILRTKIALGRKPSVIMPFYMMKNELPSPSPITGSMNLLSYYGLDHAFNKFCNNKKLKEELSAFLPNLPANIFQIVNMYFLKFSSLRQLFEKPPICGKEILPLSNSDLAGFRLLPGSIPEEYQLWNVGAEIVNDKKKRKRKHELLSAGESAEDDVEKRLKRMKKEEEKKEKKKKKKDKKKKIIMSLTLFLCVCMISLSCFHESVFADPTPVVMWHGMGDTCCNLGSLGAIISVLEREIPGIYVLSLRFGNTSTEDIENSYFGNVNKQISDVCNQIANDEHLQNGYHAIGFSQGSQFLRAVAQRCPSPPMRNYISIGGQHQGVFGLPRCRGSIKLCNFARMLLNYGAYVHVIQAQYWHDPLHENTYRDKSIFLAEINNEKVLNQTYIENLQKLQNMVMIKFTRDSMVVPPESSWFGFYAPGQAVDVIPLKETELYKNDRLGLLQMEKDGKLHFLETNGDHLQFTEKYFISEIVNKFIK
Length849
PositionHead
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.204
Instability index45.36
Isoelectric point7.92
Molecular weight97277.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
carboxy-lyase activity	GO:0016831	IEA:InterPro
pyridoxal phosphate binding	GO:0030170	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cellular amino acid metabolic process	GO:0006520	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06048
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      10|     196|      71|      80|       2
---------------------------------------------------------------------------
   71-   80 (23.87/15.59)	WHHPLFFAYY
  728-  737 (23.00/14.74)	WHDPLHENTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.25|      48|     322|     425|     480|       4
---------------------------------------------------------------------------
  425-  480 (70.23/71.71)	NNKKLKEElsAFLPNLPanifQIVNMYFLKFSslRQLFEKPP........ICGK..EILPLSNSDL
  748-  805 (72.02/49.89)	NNEKVLNQ..TYIENLQ....KLQNMVMIKFT..RDSMVVPPesswfgfyAPGQavDVIPLKETEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.51|       8|      19|     299|     310|       6
---------------------------------------------------------------------------
  299-  310 (11.52/17.14)	FRnwqiPLGRRF
  319-  326 (15.99/ 7.63)	FR....SLGVGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.49|      18|      19|     493|     510|       7
---------------------------------------------------------------------------
  493-  510 (31.02/22.73)	EYQLWNVGAEIVNDKKKR
  513-  530 (28.47/20.25)	KHELLSAGESAEDDVEKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06048 with Med19 domain of Kingdom Metazoa
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