<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06037

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLLFFFINLQLFFLYCLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQIQQQIQQHQQQQQQLQVQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKVKDRNINQPLLDAISAITKPERQKINLYEYFNFPLYQCSLKNTCPDCLKGSCENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length750
PositionTail
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.06
Grand average of hydropathy-0.759
Instability index77.45
Isoelectric point7.67
Molecular weight85485.73
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     379.57|      62|      64|     252|     313|       1
---------------------------------------------------------------------------
   24-  113 (46.09/ 6.87)	...WRSQRQ.......REKVIQHLDNvirsctvplnipgdarqvenaiflKANNQ.......................EEYMQFVSKIIYHassgaaamsQP......QRHQAPVNQvpYGNMQPGTQ.F.
  114-  166 (80.23/17.79)	.RR....AD.....MRPMQQPMQQQQ........................QQQQQ.......................QQQQQVPGQIYSG.........MR......APPN......aEMQPRLLRPMHQ
  172-  263 (74.42/15.94)	HHMHQQQAQmgqmgMTQSAGIAAAAQ........................QQPQNvvmlltsgnpprqaasapsavqlRQPNDIQQFLQQL.........PP....aiRQQILQLPP..EEQAEQLKKFFE
  264-  322 (111.44/27.78)	SRRWQQQQQ.....LHQQQQIQQQQQ........................QQQQQ.......................QQQQQIQQQIQQH.........QQ......QQQQLQVQQ..QIQ.HQMHH.V.
  323-  373 (67.39/13.69)	.....AQNQ.....MHTQAVIQQQQQ........................QQQQQ.......................QQQQQQQQQQQQH.........QQqfasvrQQQQMQMLQ..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.30|      46|      53|     397|     443|       2
---------------------------------------------------------------------------
  374-  399 (48.10/18.69)	PMM..............QQPGA....V......RFAD.Q....S...TTMLYSRPPAT
  400-  446 (87.49/43.65)	PVMIPqTPA......PVQQPPSQPAPVTP.MSGQAAS.PNVNIG...TPYPSSSPAGA
  447-  495 (49.71/19.58)	HMMGP.SPAyaaetsPVCHPAATPGPKTSqMSPAANSlPPESIGaehSPY........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.02|      53|      53|     586|     638|       3
---------------------------------------------------------------------------
  548-  584 (29.01/12.79)	.....................LK..CEETLKMICQKSdiiKVKDRNINQPllDAISAITK
  586-  638 (92.63/55.97)	ERQKINLYEYFNFPL..YQCSLKNTCPDCLKGSCENE...TAQASNVEDS..DQISIPLN
  640-  692 (77.37/45.61)	QREIGSLESKFRVTIdpSQRPLRSSC.KFISVLCELL...DITLPSVPPI...YIRIPTN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06037 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQFLQQ
2) QQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
89
343
237
494










Molecular Recognition Features






MoRF SequenceStartStop




NANANA