<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06036

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceLLFFFINLQLFFLYCLSLIMEDDWRSQRQREKVIQHLDNVIRSCTVPLNIPGDARQVENAIFLKANNQEEYMQFVSKIIYHASSGAAAMSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAAAQQQPQNVVMLLTSGNPPRQAASAPSAVQLRQPNDIQQCNIQFCTVFSLVEFECCLSDWLVSPILQQLPPAIRQQILQLPPEEQAEQLKKFFESRRWQQQQQLHQQQQIQQQQQQQQQQQQQQQIQQQIQQHQQQQQQLQVQQQIQHQMHHVAQNQMHTQAVIQQQQQQQQQQQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSPYKEKVNELLVYLEPLKRLIEQTKESTSDSSQTQKFQRMVDILEGRNDTSMDVLLKCEETLKMICQKSDIIKLCKHRELYVTVFSPDCLKGSCENETAQASNVEDSDQISIPLNIQREIGSLESKFRVTIDPSQRPLRSSCKFISVLCELLDITLPSVPPIYIRIPTNYPQSPPKYDLEWSQYCDSPYLNSIRKSLESFSSDTGAPNTISALLTNWETCVRDASFI
Length744
PositionTail
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.06
Grand average of hydropathy-0.696
Instability index80.33
Isoelectric point6.68
Molecular weight84707.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06036
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     355.47|      54|      59|     273|     331|       1
---------------------------------------------------------------------------
   91-  137 (64.18/12.57)	.....QP........QRHQAPV.nQVPygnmqPGTQ.......F..RR....ADMRPMQQPMQQQQQQQQ....................QQQQ
  138-  189 (65.61/13.02)	QQVPGQIysgmrappNAEMQPR..LLR.....PMHQPSV..............TMHHMHQ.QQAQMGQMG....................MTQS
  190-  264 (58.46/10.80)	AGIAAAA........QQQPQNVvmLLT.....SGNPPRQ......AASAPSAVQLRQPNDIQQCNIQFCTvfslvefecclsdwlvspilQQLP
  265-  317 (75.81/21.97)	PAIRQQI................lQLP.....PEEQAEQlkkfFeSRRWQQQQQLHQQQQIQQQQQQQQQ....................QQQQ
  318-  371 (91.41/21.02)	QQIQQQI........QQHQQQQ.qQLQ.....VQQQIQH......QMHHVAQNQMHTQAVIQQQQQQQQQ....................QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.69|      16|      16|     374|     389|       2
---------------------------------------------------------------------------
  374-  389 (31.24/11.17)	QQQQQQQHQ...QQFASVR
  390-  408 (26.45/ 8.19)	QQQQMQMLQpmmQQPGAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.92|      15|      16|     463|     478|       3
---------------------------------------------------------------------------
  453-  475 (18.16/ 8.31)	ASPnvnigtpYPSSSPAgAHMMG
  494-  509 (20.76/ 6.18)	PGP......kTSQMSPA.ANSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.58|      15|     250|     421|     442|       4
---------------------------------------------------------------------------
  425-  442 (23.10/24.19)	PVMIpQTPApvQQPPSQP
  678-  692 (30.48/ 9.53)	PIYI.RIPT..NYPQSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.49|      10|      16|     634|     644|       5
---------------------------------------------------------------------------
  634-  644 (13.60/12.62)	QREIGSlESKF
  652-  661 (19.89/13.00)	QRPLRS.SCKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06036 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSQPQRHQAPVNQVPYGNMQPGTQFRRADMRPMQQPMQQQQQQQQQQQQQQVPGQIYSGMRAPPNAEMQPRLLRPMHQPSVTMHHMHQQQAQMGQMGMTQSAGIAAA
2) QQQQQQQQQQQQQHQQQFASVRQQQQMQMLQPMMQQPGAVRFADQSTTMLYSRPPATPVMIPQTPAPVQQPPSQPAPVTPMSGQAASPNVNIGTPYPSSSPAGAHMMGPSPAYAAETSPVCHPAATPGPKTSQMSPAANSLPPESIGAEHSP
89
368
195
519










Molecular Recognition Features






MoRF SequenceStartStop




NANANA