<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06018

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLYEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEDDEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFVKKELERLTEMVAERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQLRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2086
PositionKinase
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.274
Instability index48.45
Isoelectric point6.64
Molecular weight236431.52
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06018
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     255.49|      37|      40|    1745|    1782|       1
---------------------------------------------------------------------------
 1745- 1772 (43.87/20.46)	................................VP........P..M..........VQ.NRQL.GIGQ......PT..LTAHYGYYPQQV
 1773- 1830 (34.51/15.95)	AMTGG..PSGAvppygqgqmwsignvqsastaVP........P.tQ..........YQ.SRNFtGAQM......TP..VQSSSG..KQAI
 1832- 1869 (31.02/12.49)	AMIRGrrPSGS...................................ggqqmmttahIQ.AAPL.ATGQ......P.........YHQQQL
 1870- 1905 (43.29/20.35)	HSIGQ..VDP.....................mVA........P..M..........HQvQMQM.DARQ......QL..M..QESMMEQQQ
 1906- 1943 (40.03/18.26)	IRTPG..PRS........................matqqhclP..Q..........VN.S....AASQ......PV..MHGNYSNYPGQ.
 2007- 2032 (37.76/16.81)	NAI.G..SS...................................................YQM.Q.SQ......QT..LRAPAGYVAQQA
 2034- 2070 (25.01/ 8.64)	PMYAA..PN..................................tpQ..........YQ.AAQ.....QqnvsmyPVsrMSQYSSNVPGQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.32|      31|      40|    1603|    1642|       2
---------------------------------------------------------------------------
 1603- 1633 (60.20/54.63)	PWEIIEGYNRENI.GLKWS..WFQGIRLDYQPET
 1643- 1676 (52.13/27.61)	PHDHHHAFNRPPMpGEPRSdpFLETLQVHYLPCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.65|      20|      65|     851|     870|       4
---------------------------------------------------------------------------
  851-  870 (37.97/23.91)	HHCYFIQLESVM..CNIWRSLL
  885-  906 (33.10/19.76)	ERCVWVYLHDLYqcCSYIRSLH
  918-  937 (36.58/22.73)	QRCLCVETKPSC..CNDLRTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.47|      33|      65|    1495|    1528|       6
---------------------------------------------------------------------------
 1495- 1528 (54.99/42.03)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRI
 1562- 1595 (52.48/34.38)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.86|      64|     334|     153|     224|       9
---------------------------------------------------------------------------
  108-  145 (41.95/28.63)	............................WFKDL.SGNKPLSALGKRFPfLNKKDEILYTLAEFNVPM
  161-  224 (117.91/74.01)	QQQECGKMKKKHMSDP..FADWTHLVMKYLRDLCSKLGEFFSLNLEVP.MNSEFECHYRHWQYTTKL
 1030- 1076 (59.00/33.14)	DQSSCDSLLNIDVSDHqcYQPLTVLVITLISRMCIRLEDFI.LHVAMP...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.99|      27|      63|    1345|    1377|      10
---------------------------------------------------------------------------
 1345- 1377 (28.51/33.88)	LVAPLISRLPSFVQgRVlKAAVSILenCQarRD
 1411- 1437 (48.48/27.41)	LLSSLLKQIQEFVM.RV.KEDPYIL..CD..RD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.57|      39|      42|     340|     380|      11
---------------------------------------------------------------------------
  304-  326 (33.31/20.31)	..........ENMK..EEDDEEEG.......TLDYLNC.PFHR
  340-  380 (68.15/59.33)	LIDCPTALIWNEME..CEDTGENGKAylCGSPLDLLHCSPVDL
  383-  423 (61.12/45.11)	FMDPSTEFVKKELErlTEMVAERSRA..VESHWSYNKCQHSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.04|      19|      83|     550|     578|      13
---------------------------------------------------------------------------
  522-  544 (25.75/19.99)	LFNylHNQapNLGEMCSSSEIKP
  560-  578 (33.30/11.31)	IFS..HDQ..YVSTLVSSGDLIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.52|      36|      83|    1182|    1234|      14
---------------------------------------------------------------------------
 1149- 1181 (41.74/13.38)	IAILML......DDSKVQELKSK.......ENFDTKRsAAKQFVEE
 1196- 1231 (63.00/67.21)	IQLLELICRQ..EWTKRKFLHST.......DLFDPKR.LLNPLVNQ
 1236- 1279 (37.77/13.40)	.RLLRMITRSdsEILLKKFDSCTtkkelisKVLDSLT.IMNLWVSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.56|      21|      42|     608|     628|      15
---------------------------------------------------------------------------
  608-  628 (39.19/23.38)	MSSNFFSEQFKPIENVDFNYF
  650-  670 (38.37/22.73)	MSSDTDSCSSKRVPKLSKHYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.98|      20|      42|    1680|    1699|      16
---------------------------------------------------------------------------
 1680- 1699 (33.97/24.85)	SD...SDKLTTERL.......KSNGPVAIS
 1708- 1737 (21.02/12.15)	SDqvqSPRTTKARArkstrgrKTSSRVTVS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06018 with Med12 domain of Kingdom Metazoa
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