<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06017

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLYEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEDDEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFVKKELERLTEMVAERSRAVESHWSYNKCQHSGLSESTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIEVSNVDFNYFKDSDESKLDFDRIIDFADKKAMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVCGIDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPVRIIIVALLFIFHHFAWFLFFFQPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQLRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2115
PositionKinase
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.245
Instability index48.07
Isoelectric point6.66
Molecular weight239927.73
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06017
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     391.40|      68|      72|    1959|    2026|       1
---------------------------------------------------------------------------
 1787- 1856 (57.63/27.30)	..................QPT..LTAHYGY......YPQQvamTGGpsgavppygqGQM.WSIGNVQSAS..TAVPPTQyQSRNFtGAQMTPVQsSSGK
 1857- 1903 (60.42/28.99)	QAIS..........................amirgrRPSG...SGG..........QQM.MTTAHIQAAPLATGQP........Y.HQQ..QLH.SIGQ
 1916- 1951 (49.32/22.25)	MQMDARQQLMQ.......ESM..MEQQQIR......TPGP...RS...............M.......ATQQ......H.CLP................
 1952- 2015 (104.50/55.74)	..........Q.vnsaasQPV..MHGNYSN......YPGQ...HGG..........GRMQMTSGRNQYAAQQPAQPPFN.CSPNY.NAQFYQAQ.NAGQ
 2016- 2072 (72.80/36.51)	LRMSQTDVIGQsnvrytqQPN..AIG..SS......YQMQ....SQ..........QTLRAPAG...YVAQQ.ANP.............MYAAP.NTPQ
 2073- 2113 (46.73/20.68)	YQAAQQQNVSM.......YPVsrMSQYSSN......VPGQ...EMN..........ASQQQI...NYY.......PP......................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.39|      28|      36|    1197|    1231|       2
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 1135- 1151 (23.49/ 8.24)	.LSLIC..........SSVDGMVPDAIL
 1153- 1178 (35.05/14.03)	LLIAILMLDDSKVQELKSKENFDTKR..
 1204- 1231 (50.85/39.85)	LLELICRQEWTKRKFLHSTDLFDPKRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     330.87|      80|     193|     798|     877|       3
---------------------------------------------------------------------------
  798-  877 (141.93/84.40)	LLGLLEESSNFISLVEFVEAIICLLPKLEAQ..IVERNFQCA.NS........LTLQYAVCMVGYMRKHH.............CY......FIQLESVMCNIWRSLLLYV
  883-  944 (78.69/43.40)	VNSFSAER..............CVWVYLHDL.......YQC...................C..SYIRSLHadlylnsrdciqrCL......CVETKPSCCNDLRTLLADV
  987- 1079 (110.24/63.85)	LCGLSGDTERLFNLVLFCADVTALCPNLNADwlAVFKILCCPfNSsqdqsscdSLLNIDVCGI....DHQ.............CYqpltvlVITLISRMCIRLEDFILHV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.44|      63|      78|    1518|    1583|       4
---------------------------------------------------------------------------
 1518- 1583 (104.83/96.07)	GfSFSGQERTNEDCKRIYNNviKKLKK.EI..G.DRQ........VPSLRCVHQLLPIPRQMVDIIVCDE...YGSQPQKG
 1586- 1663 (89.61/69.54)	G.GFSSSEVTQRKGLQIIGK..EKLNPwEIieGyNREniglkwswFQGIRLDYQPETLFEQMMRMLPHDHhhaFNRPPMPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.05|      71|      86|      16|     101|       5
---------------------------------------------------------------------------
   16-  101 (101.91/106.55)	PRlGQPD..DELTAEKVRQGFIYKPPLLNEY.ESLRSqrfdenLEDY.........FIKLTqsyNAIVNKKAEINALqdsykKKSGFKEP.SIW.HLAAK
  102-  186 (103.14/69.16)	PK.GQDTwfKDLSGNKPLSALGKRFPFLNKKdEILYT......LAEFnvpmvrvvwFLKMT...NAHIAQQQECGKM.....KKKHMSDPfADWtHLVMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.50|      46|     193|    1251|    1313|       6
---------------------------------------------------------------------------
 1262- 1313 (64.87/76.57)	CttKKELISKVLDSLTI.................MNLWvSQMDLQLLLKQ.VANSQSESLHL..VDTIaksC
 1440- 1505 (60.62/32.68)	C..DRDIVSEMLDALQLrlsliggmfdtvcrnanLENW.SLVMVQLLLYGiVTEEKNQALFYtcVDIL...C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.08|      59|      86|     552|     622|       7
---------------------------------------------------------------------------
  544-  618 (83.27/71.81)	IKPF.............tnliLLFSRLIEsdiFSHDQYVStlvssgdlIPNGANiFYPLQNQCSSAAVENVS.....................NTQPAV...LMSSN..FFSEQ
  619-  705 (62.23/33.30)	FKPIevsnvdfnyfkdsdeskLDFDRIID...FADKKAMS..........SDTD.......SCSSKRVPKLSkhyfnvlhfpvpqddqyrhecNQRQLL...LFGSN....SDQ
 1081- 1121 (38.59/14.85)	................................................MPS....LLPLWKHAGSAKVEKGS.....................EASAKLtlhLLGKIllFFDYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.31|      61|     490|     198|     275|       8
---------------------------------------------------------------------------
  198-  268 (87.93/118.30)	FFSLNLeVPMNsefeCHYRHWQYTTKL...TRHLYEEGllDKEmllNGLLDIFAEKIYASS.FGILKMLVPVLLQ
  278-  342 (93.38/69.67)	LLSRRL.VYLA....CKVLSAMKIDNLqnnSENMKEED..DEE...EGTLDYLNCPFHRTVlFGLSNVIHAVLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.27|      32|      78|    1318|    1349|       9
---------------------------------------------------------------------------
 1317- 1348 (55.37/34.55)	FQPQATLAF..GEPSD..................DKDENAYLNASSFDEIA.........P
 1349- 1393 (27.14/12.89)	YWLVAPLIS..RLPSFvqgrvlkaavsilencqaRRDRNLFVQSSSL..............
 1397- 1436 (28.76/14.13)	.QPFLSLVLicLRGQD..................DQREG..LLSSLLKQIQefvmrvkedP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.04|      16|      16|     500|     515|      10
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  500-  515 (27.63/18.11)	RLFERHL.QELSKKMPQ
  518-  534 (25.41/15.94)	HPFQKSLfNYLHNQAPN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06017 with Med12 domain of Kingdom Metazoa
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