<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06016

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMASCTVAWEKKPLKRPRLGQPDDELTAEKVRQGFIYKPPLLNEYESLRSQRFDENLEDYFIKLTQSYNAIVNKKAEINALQDSYKKKSGFKEPSIWHLAAKPKGQDTWFKDLSGNKPLSALGKRFPFLNKKDEILYTLAEFNVPMVRVVWFLKMTNAHIAQQQECGKMKKKHMSDPFADWTHLVMKYLRDLCSKLGEFFSLNLEVPMNSEFECHYRHWQYTTKLTRHLYEEGLLDKEMLLNGLLDIFAEKIYASSFGILKMLVPVLLQFIDGFVMSVLLSRRLVYLACKVLSAMKIDNLQNNSENMKEEDDEEEGTLDYLNCPFHRTVLFGLSNVIHAVLIDCPTALIWNEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLFMDPSTEFKELERLTEMVAERSRAVESHWSYNKCQHSGLSTIIQHFLSILDCLDKFKFEYVNETNNIDTLYKTIFQSEKKEMRVDVDSIAVQFLCHWAVSPHRYGSYRAAVVTRLFERHLQELSKKMPQVRHPFQKSLFNYLHNQAPNLGEMCSSSEIKPFTNLILLFSRLIESDIFSHDQYVSTLVSSGDLIPNGANIFYPLQNQCSSAAVENVSNTQPAVLMSSNFFSEQFKPIENVDFNYFKDSDESKLDFDRIIDFADKKAMSSDTDSCSSKRVPKLSKHYFNVLHFPVPQDDQYRHECNQRQLLLFGSNSDQYSRKHILKKLTKELNKLWSKKTSAELTTTGLIRVRKIIDSESLCSLSRKIQNLVFYDQFAVMDCCCDAGIAQFNSFISGQSNCLPTLENFDFLLGLLEESSNFISLVEFVEAIICLLPKLEAQIVERNFQCANSLTLQYAVCMVGYMRKHHCYFIQLESVMCNIWRSLLLYVKSKTVVNSFSAERCVWVYLHDLYQCCSYIRSLHADLYLNSRDCIQRCLCVETKPSCCNDLRTLLADVSQDIMLDVLFQESDLVIEPNLIQRLVENANLCYAFAIVAVKALCGLSGDTERLFNLVLFCADVTALCPNLNADWLAVFKILCCPFNSSQDQSSCDSLLNIDVSDHQCYQPLTVLVITLISRMCIRLEDFILHVAMPSLLPLWKHAGSAKVEKGSEASAKLTLHLLGKILLFFDYQGPKNALPAKTKGELSLICSSVDGMVPDAILTLLIAILMLDDSKVQELKSKENFDTKRSAAKQFVEEDTNTAGNSDIGSTAIQLLELICRQEWTKRKFLHSTDLFDPKRLLNPLVNQTQAQRLLRMITRSDSEILLKKFDSCTTKKELISKVLDSLTIMNLWVSQMDLQLLLKQVANSQSESLHLVDTIAKSCMEVFQPQATLAFGEPSDDKDENAYLNASSFDEIAPYWLVAPLISRLPSFVQGRVLKAAVSILENCQARRDRNLFVQSSSLLAHQPFLSLVLICLRGQDDQREGLLSSLLKQIQEFVMRVKEDPYILCDRDIVSEMLDALQLRLSLIGGMFDTVCRNANLENWSLVMVQLLLYGIVTEEKNQALFYTCVDILCVLLLSCLLPDSAGFSFSGQERTNEDCKRIYNNVIKKLKKEIGDRQVPSLRCVHQLLPIPRQMVDIIVCDEYGSQPQKGSRGGFSSSEVTQRKGLQIIGKEKLNPWEIIEGYNRENIGLKWSWFQGIRLDYQPETLFEQMMRMLPHDHHHAFNRPPMPGEPRSDPFLETLQVHYLPCTNETSDSDKLTTERLKSNGPVAISGGTLVSEFSDQVQSPRTTKARARKSTRGRKTSSRVTVSSNVALSSVPVRIIIVALLFIFHHFAWFLFFFQPMVQNRQLGIGQPTLTAHYGYYPQQVAMTGGPSGAVPPYGQGQMWSIGNVQSASTAVPPTQYQSRNFTGAQMTPVQSSSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPPFNCSPNYNAQFYQAQNAGQLRMSQTDVIGQSNVRYTQQPNAIGSSYQMQSQQTLRAPAGYVAQQANPMYAAPNTPQYQAAQQQNVSMYPVSRMSQYSSNVPGQEMNASQQQINYYPPQY
Length2107
PositionKinase
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.09
Grand average of hydropathy-0.249
Instability index48.01
Isoelectric point6.66
Molecular weight239111.75
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06016
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     292.92|      47|      85|    1937|    1983|       1
---------------------------------------------------------------------------
 1768- 1811 (32.09/12.61)	......PMVQNrqlGIG...Q.PT..LTA.............H..YGYYPQQvamTGGPSGAVPPyGQG.....QM....
 1812- 1853 (42.11/18.92)	...WSIGNVQS...AST...AvPP..TQY.............Q..SRNFTGA...QMTP.VQSSS.GKQ.....AISA..
 1888- 1920 (38.65/16.74)	QQLHSIGQVDP...MVApmhQ.V....................................QMQM.D.ARQ.....QLMQES
 1937- 1983 (88.11/47.87)	TQQHCLPQVNS...AAS...Q.PV..MHG.............N..YSNYPGQ...HGGGRMQMTS.GRN.....QYAAQQ
 1991- 2052 (36.02/15.09)	....CSPNYNA...QFY...Q.AQ..NAGqlrmsqtdvigqsNvrYTQQPNA...IGSS.YQMQS.QQTlrapaGYVAQQ
 2062- 2106 (55.94/27.62)	TPQYQAAQQQN...VSM...Y.PVsrMSQ.............Y..SSNVPGQ...EMNASQQQI....N.....YYPPQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     212.86|      62|      65|     349|     411|       2
---------------------------------------------------------------------------
  304-  330 (33.60/ 9.74)	ENMKEEDDEEEG.......TLDYLNCPFHRTVLF.........................................
  350-  411 (112.11/57.21)	NEMECEDTGENGKAYLCGSPLDLLHCSPVDLPLF.MDPSTEFKELERLT.........EM.VAERSRAVE..SHW
  414-  479 (67.16/30.31)	.....NKCQHSGLSTIIQHFLSILDC....LDKFkFEYVNETNNIDTLYktifqsekkEMrVDVDSIAVQflCHW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.05|      71|      86|      16|     101|       3
---------------------------------------------------------------------------
   16-  101 (101.91/103.70)	PRlGQPD..DELTAEKVRQGFIYKPPLLNEY.ESLRSqrfdenLEDY.........FIKLTqsyNAIVNKKAEINALqdsykKKSGFKEP.SIW.HLAAK
  102-  186 (103.14/67.28)	PK.GQDTwfKDLSGNKPLSALGKRFPFLNKKdEILYT......LAEFnvpmvrvvwFLKMT...NAHIAQQQECGKM.....KKKHMSDPfADWtHLVMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.50|      41|      86|     548|     618|       4
---------------------------------------------------------------------------
  515-  567 (58.48/49.52)	PFQKSLFNYLHNQapnlgemCSSSEIKPFTN................................liLLFSRLIEsdiFSHDQYVS..T
  576-  652 (51.02/52.26)	PNGANIFYPLQNQ.......CSSAAVENVSNtqpavlmssnffseqfkpienvdfnyfkdsdeskLDFDRIID...FADKKAMSsdT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     176.18|      42|      49|    1206|    1247|       5
---------------------------------------------------------------------------
 1160- 1204 (27.91/13.28)	.....LKSKENFD...TKRsaakqfveedtntAGNSDIGSTAIQ.LLELICRQE....
 1206- 1247 (69.98/45.82)	TKRKFLHSTDLFD...PKR.............LLNPLVNQTQAQRLLRMITRSDSEIL
 1256- 1295 (57.98/36.53)	TKKELI..SKVLD...SLT.............IMNLWVSQMDLQLLLKQVANSQSESL
 1325- 1350 (20.31/ 7.39)	DENAYLNASS.FDeiaPYW.............LVAPLISR..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.29|      29|      29|     896|     924|       6
---------------------------------------------------------------------------
  861-  891 (37.61/22.83)	.CNIWRSLL..LYVKSKTVVnsfsaERCVWVYLH
  896-  924 (56.54/38.39)	CCSYIRSLHADLYLNSRDCI.....QRCLCVETK
  927-  950 (37.15/22.46)	CCNDLRTLLADV...SQDIM.....LDVLFQE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.98|      25|      27|    1365|    1391|       7
---------------------------------------------------------------------------
 1365- 1391 (41.42/33.26)	SILENC....QARRDRNLFvqSSSLLAH.QPF
 1393- 1420 (26.79/13.90)	SLVLIClrgqDDQREGLL....SSLLKQiQEF
 1429- 1445 (23.77/11.40)	YIL..C........DRDIV..SEMLDAL.Q..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.19|      28|      29|    1676|    1703|       8
---------------------------------------------------------------------------
 1676- 1703 (46.67/38.79)	ETSD...SDKLTTERL.KSNGPVAISGGTLVS
 1704- 1735 (37.52/29.37)	EFSDqvqSPRTTKARArKSTRGRKTSSRVTVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.85|      43|      65|    1493|    1538|      11
---------------------------------------------------------------------------
 1493- 1538 (66.42/55.55)	VDIL.CVLLLSCLLPDSAGfSFSGQERTNEDCKRIYNNviKKLKK.EI
 1560- 1604 (67.43/44.72)	VDIIvCDEYGSQPQKGSRG.GFSSSEVTQRKGLQIIGK..EKLNPwEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06016 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SSGKQAISAMIRGRRPSGSGGQQMMTTAHIQAAPLATGQPYHQQQLHSIGQVDPMVAPMHQVQMQMDARQQLMQESMMEQQQIRTPGPRSMATQQHCLPQVNSAASQPVMHGNYSNYPGQHGGGRMQMTSGRNQYAAQQPAQPP
1845
1988










Molecular Recognition Features






MoRF SequenceStartStop




1) YYPPQY
2102
2107