<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06010
Description |
Mediator of RNA polymerase II transcription subunit 14 (Fragment) |
Sequence | LLMIPSVNCAITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFGNNVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVFHQLCLFSWKIQKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRMTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNTVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHESLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIVNQFDYLVIINLSNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS |
Length | 1301 |
Position | Tail |
Organism | Trichinella sp. T9 |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia>
Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
|
Aromaticity | 0.10 |
Grand average of hydropathy | 0.010 |
Instability index | 43.47 |
Isoelectric point | 6.31 |
Molecular weight | 147822.24 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP06010
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.16| 23| 28| 437| 459| 1
---------------------------------------------------------------------------
437- 459 (42.42/24.03) FTETLDLSMNLFTGKFVCRLPAF
466- 488 (42.74/24.26) FVNRIDHTMRFFTLKSCETLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 99.64| 27| 690| 383| 436| 2
---------------------------------------------------------------------------
403- 429 (48.35/63.32) LQQLCDFLRTIKGLTCTFISDMPALSI
576- 602 (51.29/16.26) FHQLCLFSWKIQKKQCVIPELMAAFSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.92| 23| 27| 834| 859| 3
---------------------------------------------------------------------------
834- 859 (37.30/29.28) TLPDTIFRVGSEHTSNQMLYlnrMFS
863- 885 (43.62/26.07) TGPDTVRLLCKDHLCLEMRF...TFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.23| 19| 90| 1162| 1181| 4
---------------------------------------------------------------------------
1162- 1181 (33.65/23.65) QQHAYVESSTAYWIpEMCFL
1251- 1269 (36.58/20.59) QQTAQQSNCTVYPI.ETCLL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.80| 17| 90| 711| 735| 5
---------------------------------------------------------------------------
711- 728 (26.89/28.69) CLD.....DVLSGVRcFNALYEP
739- 760 (25.91/ 7.65) CLHrmtplSMLSSYK.LTLVYGP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.26| 18| 34| 1086| 1103| 6
---------------------------------------------------------------------------
1086- 1103 (32.66/20.43) KFFLNE.SNL..SSVMFKFFR
1119- 1139 (22.60/11.87) KYFLEQiSSTynAAAMYAFVR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.91| 10| 27| 1007| 1016| 10
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1007- 1016 (21.57/12.02) PSSRSPPEDW
1036- 1045 (23.35/13.62) PSGTHPHPEW
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