<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06008

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLLMIPSVNCAITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVFHQLCLFSWKIQKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRMTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNTVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHESLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIVNQFDYLVIINLSNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1328
PositionTail
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.10
Grand average of hydropathy0.003
Instability index43.66
Isoelectric point6.08
Molecular weight151082.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06008
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     297.20|      88|     135|     314|     405|       1
---------------------------------------------------------------------------
  314-  362 (66.71/38.69)	.........................................GDFMSENLSVEEYVS.....SEKLVLSYWK..EQNQGGVASFKVIFWINQ.DEP..FAP
  363-  402 (38.98/27.94)	LQVTHIPKSELKLPS.MDTESGQLSLDNLLTETVLIRVkHR...........................................................
  427-  505 (98.55/62.65)	LSITFLPDSSF.......TETLDLSM.NLFT..........GKFVCRLPAFDEDISliaqlTEKLDDSHWNclED...LLHQIRVRIFVNRiDHTmrFFT
  506-  565 (92.96/58.64)	LK......SCETLPAfLKTACEQWPVD....RRFIIKF.HR.........FENYY.........IVLTF....NDHPDDSAKVNLDFWLVC.NE......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.98|      93|     718|     131|     229|       2
---------------------------------------------------------------------------
  131-  229 (141.04/130.81)	LYQMNCDVLQN.ARLP..VFQI...PTAVDVLTLGtypRLPSVIKREfIRTADISQEEEECVLHRLNY..VIERRLLPSLLTLPEgMRN..FTVNNGMVTF...HVAgEFEA
  848-  953 (135.94/100.73)	LLQASSAALQAlTTLPdtIFRVgseHTSNQMLYLN...RMFSILPTG.PDTVRLLCKDHLCLEMRFTFsgSVFMRDCGSAFGLPQ.MKSvkYVPITGFKTFlnlHIS.EMKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06008 with Med14 domain of Kingdom Metazoa
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