<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06006

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLLMIPSVNCAITKMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVNHGLVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFDEDISLIAQLTEKLDDSHWNCLEDLLHQIRYFFPFNFFVYGNEFLNFSVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRMTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNTVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHESLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1327
PositionTail
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.002
Instability index43.34
Isoelectric point6.05
Molecular weight150890.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06006
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.87|      75|     133|    1050|    1133|       1
---------------------------------------------------------------------------
 1050- 1133 (116.37/106.15)	EIQQNAFIRicsPSGTHPHPEWSHLqkfILSVEVLEkmKEQANNFTVIrPGQLSLKCN..QSEMKF...FLNESNLS.SVMFKFFRD.END
 1186- 1267 (119.50/80.54)	NIQQHAYVE...SSTAYWIPEMCFL...IPSPQLVP..TTYLSRATLM.PGGLAIVANvvQKKMLFwikFVRVADPShCVAFPFLYDgENN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.69|      27|     133|     438|     468|       3
---------------------------------------------------------------------------
  438-  464 (50.74/32.04)	PDSS..FTETLDLSMNLFTGKFVCRLPAF
  510-  538 (45.95/20.17)	NFSVriFVNRIDHTMRFFTLKSCETLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.41|      44|     656|     242|     291|       4
---------------------------------------------------------------------------
  242-  291 (62.73/46.39)	LPRTPWTllnLRILVSDP.....RVT.DGSDILSSLQLSFlhHLIQSRlNVSKEPI
  899-  948 (69.68/35.73)	LPTGPDT...VRLLCKDHlclemRFTfSGSVFMRDCGSAF..GLPQMK.SVKYVPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     172.80|      65|     317|     293|     361|       5
---------------------------------------------------------------------------
  293-  325 (45.14/28.81)	.................................................................................................................................................................................................................................................................................................EL.Y..RVIHCFCLSAQLDI.LCCQAYRLIGDF.MSEN
  326-  361 (29.32/31.01)	LSVEEYvssEKLVLSYWKEQNQGGVASFKVIfWINQ...................................................................................................................................................................................................................................................................................................
  615-  643 (25.26/11.53)	....................................depfaplqvthipkselklpsmdtesgqlsldnlltetvlirvkhrlqqlcdflrtikgltctfisdmpalsitflpdssftetldlsmnlftgkfvcrlpafdedisliaqlteklddshwncledllhqiryffpfnffvygneflnfsvrifvnridhtmrfftlkscetlpaflktaceqwpvdrrfiikfhrfenyyivltfndhpddsakvnldfwlvcnetvsnairsadadddvrskknvnllhfDL.R..RVVSETKVKKQ......CVIPELMAAFsMCEN
  649-  708 (73.09/54.51)	LLMEEM...ERTSARYAYHQLFDGTVVLRVL.GIDQ...............................................................................................................................................................................................................................................................tYdrNLEKIFGLPKGLAIgLSCDRHRVV........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.79|      46|     457|      75|     129|       7
---------------------------------------------------------------------------
   75-  129 (59.83/63.62)	DRKIsIAQFaHSarqlFVRLYAILKWAR...cGAKVDLCTGIVCflDQQASMFVDTAD
  549-  598 (77.96/47.81)	DRRF.IIKF.HR....FENYYIVLTFNDhpddSAKVNLDFWLVC..NETVSNAIRSAD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06006 with Med14 domain of Kingdom Metazoa
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