<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05999

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEECEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANKIVDFFVRNVIQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQPQQPQQQQQQQQPQPQQSNVVVGSSQQPQQQQQSRFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWYSNSNSV
Length1199
PositionTail
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.064
Instability index48.69
Isoelectric point7.11
Molecular weight138282.04
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05999
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.77|      16|      16|     760|     775|       1
---------------------------------------------------------------------------
  760-  775 (33.76/19.84)	QQQQQQQQQQQQQQQQ
  777-  792 (32.96/19.19)	QQQQPQQPQQQQQQQQ
  806-  821 (29.04/16.01)	QQPQQQQQSRFLLKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.92|      21|      40|    1030|    1051|       2
---------------------------------------------------------------------------
  857-  877 (19.63/ 9.18)	.RLVydtgELPAVSMKILE....VLG
 1030- 1051 (32.41/24.54)	QKLV....ESPAACLKFLDsTLSILG
 1073- 1091 (32.89/20.01)	KRLV....ESPAIKQKL...ALAVHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.42|      34|      40|     456|     495|       3
---------------------------------------------------------------------------
  458-  495 (54.35/43.93)	LKNKTQFN....TDNYMvavlCNAYSS....TSEIFQQDLLPILLE
  497-  538 (46.07/23.46)	LDNTRGHNstqaSGNFA....SNTTSSmpypNGAVSEVKLRPLKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.50|      34|     263|     105|     141|       6
---------------------------------------------------------------------------
  105-  141 (51.10/49.37)	EKLLTCAeLNINSCGWN....DTFAFFMENISLLdYKGvRD
  371-  408 (58.40/40.25)	NQLMWCL.FNFLSGGMQkysvEEFAVILDLYRLL.YTG.RD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.59|      31|      40|     579|     617|       7
---------------------------------------------------------------------------
  582-  617 (53.30/58.98)	LTY.....PDL....EILGLKQftshiVLTAARHQCCEMMYICCE
  619-  658 (43.29/25.05)	LNYrlfniPSTyrvhAIVTLQQ.....TLAFAKFQTNASLYWMLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.07|      24|      58|     263|     288|       8
---------------------------------------------------------------------------
  263-  288 (40.85/33.67)	Y....................SQdlLNPQ.MRLLTHVFMHYTYRDAI
  304-  348 (24.93/13.09)	YfeeviteiilelmftaecdhSQ..LNPQaWRIISTQIIYLTLQQSI
  350-  369 (23.29/11.02)	.........................FTRL.VKILHTKLTHYPYRYA.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05999 with Med23 domain of Kingdom Metazoa
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