<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05993

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSVSLSDFEAKVKNLFKEHAKSGIAHFFFRPYLITSSEECEKEIVISTANELMEIFTSLPQNLQESAFSIVISHRVLSNSANKIVDFFVRNVIQRQMLSIKCICEKLLTCAELNINSCGWNDTFAFFMENISLLDYKGVRDTLKRLLDIPIPVHLQVDQRKSVEAVEKLIKTICDRKNNLLPAYFVITEIIKNLPEQRCFSHWRMADCFTEIIESFRPLAQLNSVCGRTFMTPIPGHVGFYFNAFWKLEALSLRFPLKGLLPYSQDLLNPQMRLLTHVFMHYTYRDAIAVLLGTAKPEKSRIPYFEEVITEIILELMFTAECDHSQLNPQAWRIISTQIIYLTLQQSICFTRLVKILHTKLTHYPYRYARNQLMWCLFNFLSGGMQKYSVEEFAVILDLYRLLYTGRDIFTVSGSDSSCVLMLAPTCIWIHILKKSPSMEVELPPTVNTQRKFLQEALKNKTQFNTDNYMVAVLCNAYSSTSEIFQQDLLPILLENLDNTRGHNSTQASGNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSVSVHVRMNIANSLIGTFGRFMQGKSAWPSPALVETYCRMLTYPDLEILGLKQFTSHIVLTAARHQCCEMMYICCEILNYRLFNIPSTYRVHAIVTLQQTLAFAKFQTNASLYWMLERTLLLQFQWYPHYEIFQAPFARLLNSFVAVAADGTKQSIAENEELMRIIILTLARSTVISSNSDSCFIEGVYRELLNKLPSYSWPQSTLSVFPQVFCSHYTQQQQQQQQQQQQQQQQQQQQQPQQPQQQQQQQQPQPQQSNVVVGSSQQPQQQQQSRFLLKQQVDEEYIKHRTFGSELSLIDYFTNTSTSTVYLCLLWRLVYDTGELPAVSMKILEVLGPRKVLVHLKSLADFLVYETNSADVNRCVDVLNRLIFKYAVVPLERFMLTMLLRDYEGNDAFYALLIVMLLVQRSEELRSAVADCVAMLPSDYWHCQDWNDKYQAYQIKHAERTWSQVYVELSRASLTPNDCPLPVYFGTRCLQMLPVVDLLLQKLVESPAACLKFLDSTLSILGPLYRFHPYPVSFLYSTFRFYEKRLVESPAIKQKLALAVHGACVPSRDDHWLLSAEFVGWVGQATDRGPWVPDLNYYGALVRRLIDTFSEPRQQWSRKTDLRFVEFNNFQTHALYSICIELMSLPVGVVDVGNALVTLVTHWHSLVDKNTLMYWVNAIGLIFSALPISYMEPFYQTILTTLCSDNMNSINTDVSNKLDFEKRSKLMEDCYPARILALCHAVWLHSTSGYLQLLPQALRSTWIPHVRSEGQFLYVCHLVAPFLQRFYQERTKFTMDMLYNVDCEVGNWKYEDLICDFFYHVKYMYVGDSVRQDTDRIIPMLRPSLQQKLRYISFAQGEQSAGTPFSEMINPIKLLGIQMVVWLQRLPIFGETAQHFWLAVTKLGDPVMTFSLYFPALFPFFGTAALDMVIVGAFSEISNCILKWILLDDRPYWWVHTAGVSGQLSHPLKQFQWTCETGPGSPSGHAMVSASVWFNLLYNLQSDLVLGDLCGICWLLYVVFLIAVSISRTYISAHFPDQVILGIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGVDTHRSIELAAKYCHRAEWIHLSTTPLASFFRDVGVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVSLNQLVAFIPIGRLPTALFYAVLLPALIVLLLTMVLDLDNFRVEKGGNVQAVRVSQQKRFQSVDLVDQVVETDQEWRRSRYLSDEWNRLKNLCSKEIGEKIKRKEPVDGNSTLPDSLTDKLQKLTVDQIRALSVGQIKQLRLLIDHEMEKSYKLVENLEAVRFKALSQIGNLVHNSVPVSENEDDNEIVRTWGELEVRKKYSQVDLGIMVDGYDSERGCSVAGSRGYFLKGPLVFLEQALIQLAMHMLFKKKYTPLYTPFFMRKEVMQEVAQLSDFDDQLYKVIGKSSEVKEEIAEEEKYLIATSEQPIAAYHRDEWISKESLPLRYVGFSTCFRQEVGSHGRDTSGIFRVHQFEKVEQFCITSPHDDASWEMLEEMISNAEMFYQTLNIPYRVVSIVSGELNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQSRRLRIRYGQTKKMMAKAEFVHMLNGTMCATTRTICAILENFQEENGIAVPEALRQYMPDDYKDFIPFVKPAPKVEQAAKRGGNKSATAEKSTQ
Length2219
PositionTail
OrganismTrichinella sp. T9
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella> unclassified Trichinella.
Aromaticity0.11
Grand average of hydropathy-0.047
Instability index44.23
Isoelectric point6.99
Molecular weight254810.57
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
serine-tRNA ligase activity	GO:0004828	IEA:UniProtKB-EC

GO - Biological Process
seryl-tRNA aminoacylation	GO:0006434	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05993
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.77|      16|      16|     760|     775|       1
---------------------------------------------------------------------------
  760-  775 (33.76/18.98)	QQQQQQQQQQQQQQQQ
  777-  792 (32.96/18.35)	QQQQPQQPQQQQQQQQ
  806-  821 (29.04/15.28)	QQPQQQQQSRFLLKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.06|      15|      17|     924|     940|       2
---------------------------------------------------------------------------
  924-  938 (27.40/12.74)	MLTMLL..RDYEGNDAF
  942-  958 (17.67/ 8.24)	LIVMLLvqRSEELRSAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.91|      37|      80|    1423|    1459|       3
---------------------------------------------------------------------------
 1423- 1459 (64.36/36.90)	QHFWLAVTKLGDP....VMTFSLYFPALFPFFGTAALDMVI
 1462- 1490 (31.35/14.05)	.....AFSEISNC....ILKWILLDDRPYWWVHTAGVS...
 1499- 1535 (46.72/24.70)	QFQWTCETGPGSPsghaMVSASVWFNLLYNL....QSDLVL
 1540- 1569 (44.48/23.14)	GICWLLYVVFLIA....VSISRTYISAHFP.......DQVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.19|      49|      80|    1571|    1619|       4
---------------------------------------------------------------------------
 1571- 1619 (80.69/54.57)	GIVVGICIALVTRSLVGHRRRRWSNLIAFMIALLLIALSVHEVHRFFGV
 1653- 1701 (76.49/51.32)	GVLISVAILLANKSMFTNNNKIASKFFSTKFAQALLGVSLNQLVAFIPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.72|      15|      85|     273|     287|       5
---------------------------------------------------------------------------
  273-  287 (28.85/20.61)	RLLTHVFMHYTYRDA
  355-  369 (28.86/20.62)	KILHTKLTHYPYRYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.13|      41|      85|     112|     154|       6
---------------------------------------------------------------------------
  112-  154 (70.99/50.47)	ELNINSC..GW..NDTFAFFMEniSLLDYKGVRDTLKRLLDIPIPVH
  193-  237 (68.14/42.54)	NLPEQRCfsHWrmADCFTEIIE..SFRPLAQLNSVCGRTFMTPIPGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.59|      34|      85|     545|     590|       7
---------------------------------------------------------------------------
  510-  543 (57.28/46.42)	GNFASNTTSSMPYPNGAVSEVKLRPLKLEFLDSV
  557-  590 (62.31/31.28)	GTFGRFMQGKSAWPSPALVETYCRMLTYPDLEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.84|      22|      85|    1120|    1144|       8
---------------------------------------------------------------------------
 1120- 1141 (40.59/30.13)	WVPDLNYYG.......ALVRRLIDTFSEP
 1147- 1175 (31.24/13.60)	RKTDLRFVEfnnfqthALYSICIELMSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.00|      71|      86|    1222|    1298|       9
---------------------------------------------------------------------------
 1222- 1298 (116.65/87.46)	PFYQTILTTLCSDNMnsintDVSNKLDFEKRSKLMED..C...YPARILALCHAVWlHSTSGYLQLLPQALRST..WIPHVRSE
 1310- 1387 (115.34/72.16)	PFLQRFYQERTKFTM.....DMLYNVDCEVGNWKYEDliCdffYHVKYMYVGDSVR.QDTDRIIPMLRPSLQQKlrYISFAQGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.12|      37|      40|    1001|    1037|      12
---------------------------------------------------------------------------
  993- 1010 (19.71/ 7.77)	.....................QVYVELSRASLTPNDCPL
 1011- 1047 (65.92/48.24)	PVY.FGTRCLQML.PVVDLLLQKLVESPAACLKFLDSTL
 1052- 1080 (33.49/19.84)	PLYrFHPYPVSFLySTFRFYEKRLVESPA..........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05993 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQQQQQQQQQQPQQPQQQQQQQQPQPQQSNVVVGS
765
804










Molecular Recognition Features






MoRF SequenceStartStop




1) DYKDFIPFVKP
2) PKVEQAAKRGGNKSATAEKST
2186
2198
2196
2218