<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05983

Description Coiled-coil domain-containing protein 47
SequenceMIMRMQEVDKNFINSVGGIVQNIKSIQSSISEVLAKLQMVDQPSLLNSFRVISSQFNSMLQLLRSDRASHFKNYVFLPIKLSVEVDADLEAATENRLHAWTHAVVPDYLRTKPDPQVEQKDQQISNQVQQRICNPESLQKQITAFNRCLNCILDSLNASIRDSEMDGRKTSKTSDGEDTALLVAAILKGQNVKPAYSATPASSRGSSGDSGHSKASKAQVRIATTHHPCCFILKKQCMAKNKCSININQFTTERRKTCIWMFFLSCLFEFVELSVKQVSQIDDNEFAEFEEFDVELDASVDADFTANNVNERETPPVDTASIGAKRSPAYAEQKLNDAPNNNFNDDDYGIVEDESVDDFSHLLDENEFENFPDERRPGKQNAGPSKTVTQLKITDVPGHLRNNWNNFVVELFLIFGLVVYTKNHSLAVAWFDSNRPFLEENFSIVGDDGISPEVTKNVLIKESDNHYIVWCSGRQGCIGMEIHLKLIKRQDLLSLIFYIIRPKFDVIEIKIILNPEEMDPFVFALGTKRSAIKNSKEIMDLNLYCSEKKNVEKLGLPSSYILHSEIGEVTTGLIDTKIVSALCKYKDVVDYIHISDQFVGIKPIEMENMTKPPETAKVVMICLNIPGQLRATEEDVSSLQPLMIFIFHVLEKVRRFRLTREGKQKADKNRQYVEESFLKTTHAQRQEAAQQRREERARERKERLMAEEDPERQRKLEKQELKRELKKKQPRVKQIKIKAMLRFLIKAKQIHC
Length752
PositionHead
OrganismTrichinella murrelli
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.07
Grand average of hydropathy-0.454
Instability index42.95
Isoelectric point6.64
Molecular weight85976.30
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
rough endoplasmic reticulum membrane	GO:0030867	IEA:UniProtKB-SubCell

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05983
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.74|      18|      26|     446|     464|       1
---------------------------------------------------------------------------
  446-  464 (27.32/21.56)	GDDG.ISPEVTKNvLIKESD
  473-  491 (28.42/17.49)	GRQGcIGMEIHLK.LIKRQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.49|      78|     228|     356|     442|       2
---------------------------------------------------------------------------
  356-  442 (128.41/109.93)	VDDFSHLLDenefeNF....PDERrpgkQN.AGPSKTVTQLKI.TDVPGHLRNNWNNF.VVELFLIFGLVVYTKNHSLAVAW.....FDSNRPFLEENF
  588-  677 (111.09/75.29)	VVDYIHISD.....QFvgikPIEM....ENmTKPPETAKVVMIcLNIPGQLRATEEDVsSLQPLMIFIFHVLEKVRRFRLTRegkqkADKNRQYVEESF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.90|      39|     594|     109|     149|       4
---------------------------------------------------------------------------
  109-  149 (62.23/42.12)	LRTKPDPQVEQK..DQQISNQVQQRicNPESLQKQITAFNRCL
  704-  744 (58.67/33.16)	LMAEEDPERQRKleKQELKRELKKK..QPRVKQIKIKAMLRFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.75|      12|      26|     525|     536|       7
---------------------------------------------------------------------------
  525-  536 (19.41/10.88)	LGTKRSAIKNSK
  554-  565 (20.34/11.71)	LGLPSSYILHSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05983 with Med8 domain of Kingdom Metazoa
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