<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05974

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKFKANEMSSGMPLKSKPGVDHSRNNTMYTCSNQRTTVFLRSSSVYPLTVALPSSTSSSGQIHLLDQSASATTIHQPLLIKTCESLILSLGRSVILNVKCIYNKENISCTGYYVERPTVADGTPAPEKPTLYVMERYIEKCKNEFNVKFLGTEKRSPLDAEDRVEVAKSYERLLQGLRVASAYELFGRLEDIATKMNLTFVRTPGTANNQSCFITADCFFLEISAEETGSVFLVNVTHEKQTSESVLLRDIINDKRWTELQRHLWGLCSAYIPCKDIDTKNQAFKFMQNLENILHIQSLQRINDNTLPVVEYLRTSDMYFFRRREVGDPPRLYFFCTPLSFWDSETGDFKQLFQNDIDNVMDVSKFKSIIYAELAMENVQGEQFLSISMQSVNALGQFHDIPMSMQIAAVFTLTFPEKLIISMDSVTKIEALTGFKPAFSNQSKILDLILGEILSSGFSVLRSFVLLEDQLHCYTVDLEGCLTEGVVLEKIYWTNLEVLHKILPILRTEALFKHIFTSFIRNITTTQKQFAQKIFRRDIHVIPSPDLSILECQVKLPREREFFYIVFRLAPINEISVKVGGVVDNADVNLNDVAYEVFSRVWSIPVTIRALVKQLLCLSERNVVVAAAGDGNSGNGDHQNDVVLMQIDCDRSLHLSTDSNCAAHSSVSIPDGNYNMSEYSVCNDDANGVAVADDADDDADAVISVSGIAQSLIIEQQMQKLIVNVDKVLEELLLVCSGRLAGGPNLLDLFKKPKVWRELIPPRRCAGRRGQRSRQQMAPPLAQQCCASAAGQLPAPVAAVAAAAPFGKVGPNLKSRHFSSTSETLTELDELCQLSSSCAEGNGHQSEHASACGDSAVADGGEQKSSIQDTIDSVLGSVRFPGSMAESLINISSCCINNNNNTNNSNPNSNNSNANTSNNNNTNSNNNNNNNSNNSMNALASIRKIELGYGQSSAGVAAPMSSSSSPALAAPMSRSSDSTGDVFDYETRSTTTAGMSIDQGGRSLSSSVCCADDLSIAAASASAPTLDVGFWPPAGGVERLDVRGALLNRGMRRRRRCRKAFANTGDRALDMVLKEMRKAERLVRGASSTRRPRRSRLATATASFTADMREVASKVTLKIRSSSAAALPGVQTAQESSSLAVASSSLSSADQGSSSGGKDEQKKSLKLAANANASGGAGAATLNTWTQPSSSVFRSLSDATGESCSSRSSSPPPQLVKPASKRKNSLDVVIGKLMDKVGTSPTKLDPSSDVPDSAGDKQRHLYGFCFSPTASQQQKSGTTAASVSASEFTIHKRGECSTTATTTAMATSTGELSDAPEGGIKLVIKKGVIKLKSARHGRGAGAGRFVETGAPSARPRVSSPASAGDRLAASKFELLKQKMQARKIKRQSSTEKSRQRGPRSGALAAASKTAANRSKLSTVGSSSSGVAELPSVFPGAEGLLFSKSLKGFKIPKIDDNSSKTTTATTAATVTAAPASTSDSANTTTTVTVSTTTTATVVPAAASAAATMTTTTTTTNIVSATAAAAVVTSASTVATGTTTSANATATASVAVTPLTVVEKRMADGPPMALVVNDGRASPAGVVSGGGGGILRMKPPLLAVQQVPPPCVGGSSKPLIRRSRPVPLPLPPRSLVATGPHFAGPPAVELALPTGPAVPRYVRRTLLPNPPLQTASSPRPPPPQPLLELNKHHQQQMLVHSTTQQRPTKQELLNPMTNQMSPKSASPDPTGLVIDDNLNTTAAISSPQKNAEEVDVLSPGLRIAVDEGDETKGPTTHSSSTT
Length1776
PositionMiddle
OrganismTrichinella murrelli
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.05
Grand average of hydropathy-0.247
Instability index49.04
Isoelectric point8.79
Molecular weight189715.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05974
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.95|      24|      24|    1490|    1513|       1
---------------------------------------------------------------------------
 1464- 1488 (29.07/14.16)	.TTAATVTaaPASTSDSANTTTTVTV
 1490- 1513 (42.44/24.46)	TTTTATVV..PAAASAAATMTTTTTT
 1519- 1538 (31.44/15.98)	ATAAAAVV......TSASTVATGTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.78|      16|      27|     898|     924|       2
---------------------------------------------------------------------------
  898-  914 (27.72/31.16)	NNNNTNNSNpNSNNSNA
  925-  940 (32.06/10.00)	NNNNNNNSN.NSMNALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.92|      13|      16|    1145|    1157|       3
---------------------------------------------------------------------------
 1145- 1157 (23.35/10.79)	SLSSADQGSSSGG
 1164- 1176 (18.62/ 6.99)	SLKLAANANASGG
 1181- 1193 (21.95/ 9.66)	TLNTWTQPSSSVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.84|      24|      36|    1591|    1626|       4
---------------------------------------------------------------------------
 1591- 1623 (34.89/29.75)	MKPPllAVQQVPP..PCVggsskPliRRSRPVPLP
 1637- 1662 (38.95/16.55)	AGPP..AVELALPtgPAV.....P..RYVRRTLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.67|      15|      15|     777|     791|       5
---------------------------------------------------------------------------
  777-  791 (28.68/13.38)	MAPPLAQQCCASAAG
  793-  807 (23.99/10.06)	LPAPVAAVAAAAPFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.06|      17|      21|     836|     855|       6
---------------------------------------------------------------------------
  838-  855 (28.29/22.78)	CAEGnGHQSEHASACGDS
  857-  873 (28.76/11.70)	VADG.GEQKSSIQDTIDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     519.55|     138|     284|     965|    1144|       7
---------------------------------------------------------------------------
  667-  774 (130.35/66.60)	VSIPDGNYNMSEYSVCNDDANGVAVADDADDDADAVISVSGIAQSLIIEQQMqklivnVDKVLEElLLVCSGR....LAG.G.PNLLDLF.................KKPKVWRELIPPRRCAGR.RGQRSR.........................................
  995- 1135 (219.66/143.09)	MSIDQGGRSLSSSVCCADDLSIAAASASAPTLDVGFWPPAGGVERLDVRGAL......LNRGMRR.RRRCRKA....FANTG.DRALDMV.................LKEMRKAERLVRGASSTR.RPRRSRL.ATATASFTADMRevaSKV.TLKIRSSSAAALPGVQTAQE
 1282- 1437 (169.54/90.98)	.SVSASEFTIHKRGECSTTATTTAMATSTGELSDA...PEGGI.KLVIKKGV......IK..LKS.ARHGRGAgagrFVETGaPSARPRVsspasagdrlaaskfelLKQKMQARKIKRQSSTEKsRQRGPRSgALAAASKTAANR...SKLsTVGSSSSGVAELPSVFPGAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.01|      29|     282|     965|     993|       9
---------------------------------------------------------------------------
  965-  993 (52.19/28.72)	SPALAAPMSRSSDSTGD....VFDY........ETRSTTTA
 1240- 1280 (37.83/18.65)	SPTKLDPSSDVPDSAGDkqrhLYGFcfsptasqQQKSGTTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.59|      20|     282|     232|     251|      10
---------------------------------------------------------------------------
  232-  251 (33.57/22.72)	FLVNV.THEKQTSESVLLRDI
  519-  539 (31.02/20.43)	FIRNItTTQKQFAQKIFRRDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|     282|     343|     357|      12
---------------------------------------------------------------------------
  325-  339 (21.12/10.54)	EVGDPPRLyfFCTPL
  345-  357 (23.75/ 9.94)	ETGDFKQL..FQNDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05974 with Med1 domain of Kingdom Metazoa
Unable to open file!