<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05947

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSGDEESMDFEEKLAAFPLPSIPANQGPPFMAFGVLLDFAVQKTYQDFVILTDLLPKKSDLDRKISIAQFAHSARQLFVRLYAILKWARCGAKVDLCTGIVCFLDQQASMFVDTADRLYQMNCDVLQNARLPVFQIPTAVDVLTLGTYPRLPSVIKREFIRTADISQEEEECVLHRLNYVIERRLLPSLLTLPEGMRNFTVNNGMVTFHVAGEFEAQLTLLGQLPRTPWTLLNLRILVSDPRVTDGSDILSSLQLSFLHHLIQSRLNVSKEPIVELYRVIHCFCLSAQLDILCCQAYRLIGDFMSENLSVEEYVSSEKLVLSYWKEQNQGGVASFKVIFWINQDEPFAPLQVTHIPKSELKLPSMDTESGQLSLDNLLTETVLIRVKHRLQQLCDFLRTIKGLTCTFISDMPALSITFLPDSSFTETLDLSMNLFTGKFVCRLPAFGNNVRIFVNRIDHTMRFFTLKSCETLPAFLKTACEQWPVDRRFIIKFHRFENYYIVLTFNDHPDDSAKVNLDFWLVCNETVSNAIRSADADDDVRSKKNVNLLHFDLRRVVSETKVFHQLCLFSWKIQKKQCVIPELMAAFSMCENAMPFFLLMEEMERTSARYAYHQLFDGTVVLRVLGIDQTYDRNLEKIFGLPKGLAIGLSCDRHRVVWSIELNTTGSPLGDSSSFGRAVHRKITILSCTVGNESARKCLDDVLSGVRCFNALYEPVKALAGAYKSCLHRMTPLSMLSSYKLTLVYGPMLRYVCHLQWKPSEKMYILSFGVDNSVLNEEYVYFNPHSILCGHLQHWFNAVRDISALAHLLQASSAALQALTTLPDTIFRVGSEHTSNQMLYLNRMFSILPTGPDTVRLLCKDHLCLEMRFTFSGSVFMRDCGSAFGLPQMKSVKYVPITGFKTFLNLHISEMKAAIEAERKVSTAVHDSLMEVSDVDFSGNTFQANPNSGTGSSMVLENSMRTSTQNRLIGNSLANDDGHAEPSSRSPPEDWTPCVVPIEIQQNAFIRICSPSGTHPHPEWSHLQKFILSVEVLEKMKEQANNFTVIRPGQLSLKCNQSEMKFFLNESNLSSVMFKFFRDENDACTESDVQFLEKYFLEQISSTYNAAAMYAFVRMLTVCQTIRRDLLSSFLSIMNIQQHAYVESSTAYWIPEMCFLIPSPQLVPTTYLSRATLMPGGLAIVANVVQKKMLFWIKFVRVADPSHCVAFPFLYDGENNSLQVFRGTNQQTAQQSNCTVYPIETCLLRQQQTHSAFSECVVWPCIRDVMHINELIPGRS
Length1276
PositionTail
OrganismTrichinella murrelli
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Enoplea> Dorylaimia> Trichinellida> Trichinellidae> Trichinella.
Aromaticity0.10
Grand average of hydropathy-0.010
Instability index43.85
Isoelectric point6.30
Molecular weight144930.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05947
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.16|      23|      28|     424|     446|       1
---------------------------------------------------------------------------
  424-  446 (42.42/21.47)	FTETLDLSMNLFTGKFVCRLPAF
  453-  475 (42.74/21.68)	FVNRIDHTMRFFTLKSCETLPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.08|      25|      28|     819|     846|       2
---------------------------------------------------------------------------
  819-  846 (40.47/30.24)	LTTLPDTIFRVGSEHTSNQMLYlnrMFS
  848-  872 (47.61/27.75)	LPTGPDTVRLLCKDHLCLEMRF...TFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.23|      19|      90|    1137|    1156|       3
---------------------------------------------------------------------------
 1137- 1156 (33.65/23.95)	QQHAYVESSTAYWIpEMCFL
 1226- 1244 (36.58/20.86)	QQTAQQSNCTVYPI.ETCLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.80|      17|      90|     698|     722|       4
---------------------------------------------------------------------------
  698-  715 (26.89/29.30)	CLD.....DVLSGVRcFNALYEP
  726-  747 (25.91/ 8.01)	CLHrmtplSMLSSYK.LTLVYGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.26|      18|      34|    1061|    1078|       5
---------------------------------------------------------------------------
 1061- 1078 (32.66/22.23)	KFFLNE.SNL..SSVMFKFFR
 1094- 1114 (22.60/12.97)	KYFLEQiSSTynAAAMYAFVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     322.00|     101|     793|     188|     295|       9
---------------------------------------------------------------------------
  188-  295 (151.76/125.41)	SLLTLPEGMRNfTVNNGMVTFHVAGEfEAQLTLLGQLPRTPWTLLNLRILVSDP...RVTDGSDILSSLQLSFLHHLIQS..RLNVSKEPiVELYRVIHcfclSAQLDILCCQ
  952- 1057 (170.24/113.32)	SSMVLENSMRT.STQNRLIGNSLAND.DGHAEPSSRSPPEDWTPCVVPIEIQQNafiRICSPSGTHPHPEWSHLQKFILSveVLEKMKEQ.ANNFTVIR....PGQLSLKCNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.15|      74|     246|     318|     405|      11
---------------------------------------------------------------------------
  318-  403 (114.94/117.57)	KLVLSYWK.EQNQGGVASFKVIFWI.NQDEPFAplqvthipkseLKLPSMDTESGQLSLDNLLTETVLIRVKHrLQQLCDF.LRTIKGL
  565-  641 (118.21/83.54)	QLCLFSWKiQKKQCVIPELMAAFSMcENAMPFF...........LLMEEMERTSARYAYHQLFDGTVVLRVLG.IDQTYDRnLEKIFGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05947 with Med14 domain of Kingdom Metazoa
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